Evaluation of CA-125 and soluble CD-23 in patients with pelvic endometriosis: a case-control study

Ramos, Ivana Maria de Luna; Podgaec, Sérgio; Abrão, Maurício Simões; Oliveira, Ricardo de; Baracat, Edmund Chada

doi:10.1590/s0104-42302012000100011

Cited by 7 publications

(2 citation statements)

References 22 publications

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“…CA-125 has been measured simultaneously with urocortin [ 34 ], chlamydia antibody [ 35 ], CD23 [ 39 ], and inflammatory cytokines [ 32 ]. However, none of these combinations provided a sufficiently high sensitivity or specificity for endometriosis and results remained unvalidated.…”

Section: Blood Biomarkersmentioning

confidence: 99%

Update on Biomarkers for the Detection of Endometriosis

Fassbender

Burney

et al. 2015

BioMed Research International

145

127

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Endometriosis is histologically characterized by the displacement of endometrial tissue to extrauterine locations including the pelvic peritoneum, ovaries, and bowel. An important cause of infertility and pelvic pain, the individual and global socioeconomic burden of endometriosis is significant. Laparoscopy remains the gold standard for the diagnosis of the condition. However, the invasive nature of surgery, coupled with the lack of a laboratory biomarker for the disease, results in a mean latency of 7–11 years from onset of symptoms to definitive diagnosis. Unfortunately, the delay in diagnosis may have significant consequences in terms of disease progression. The discovery of a sufficiently sensitive and specific biomarker for the nonsurgical detection of endometriosis promises earlier diagnosis and prevention of deleterious sequelae and represents a clear research priority. In this review, we describe and discuss the current status of biomarkers of endometriosis in plasma, urine, and endometrium.

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Section: Blood Biomarkersmentioning

confidence: 99%

Update on Biomarkers for the Detection of Endometriosis

Fassbender

Burney

et al. 2015

BioMed Research International

145

127

View full text Add to dashboard Cite

show abstract

“…Ovarian carcinoma is diagnosed by CA-125. It is a tumor-associated antigen released by the coelomic epithelium that serves as a useful biomarker for endometriosis [ 93 ]. It is secreted in bodily fluids in soluble form or expressed on cell surfaces that experience metaplastic differentiation into Müllerian-type epithelium.…”

Section: Biomarkers Of Reproductive Cancersmentioning

confidence: 99%

Developing a deeper insight into reproductive biomarkers

Wahid

Bashir

Bilal

et al. 2017

Clin Exp Reprod Med

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The development of biomarkers of reproductive medicine is still in its infancy because many black boxes are still present in reproductive medicine. Novel approaches to human infertility diagnostics and treatment must be developed because reproductive medicine has lagged behind in the implementation of biomarkers in clinical medicine. Despite the dearth of the available literature, the current rapid pace of publications suggests that this gap will soon be filled therefore; this review is a précis of the research that has been done so far and will provide a basis for the development of biomarkers in reproductive medicine.

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Blood biomarkers for the non-invasive diagnosis of endometriosis

Nisenblat

Bossuyt

Shaikh

et al. 2016

Cochrane Database of Systematic Reviews

188

161

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Of the biomarkers that were subjected to meta-analysis, none consistently met the criteria for a replacement or triage diagnostic test. A subset of blood biomarkers could prove useful either for detecting pelvic endometriosis or for differentiating ovarian endometrioma from other benign ovarian masses, but there was insufficient evidence to draw meaningful conclusions. Overall, none of the biomarkers displayed enough accuracy to be used clinically outside a research setting. We also identified blood biomarkers that demonstrated no diagnostic value in endometriosis and recommend focusing research resources on evaluating other more clinically useful biomarkers.

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Evaluation of CA-125 and soluble CD-23 in patients with pelvic endometriosis: a case-control study

Abstract: The concentrations of CA-125 were higher in patients with endometriosis than in patients without the disease. No significantly differences were observed for soluble CD-23 levels between groups.

Cited by 7 publications

References 22 publications

Update on Biomarkers for the Detection of Endometriosis

Update on Biomarkers for the Detection of Endometriosis

Developing a deeper insight into reproductive biomarkers

Blood biomarkers for the non-invasive diagnosis of endometriosis

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