Doença do refluxo gastroesofágico: tratamento farmacológico

doi:10.1590/s0104-42302011000600006

Cited by 2 publications

(1 citation statement)

References 83 publications

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“…Eighty-three percent of patients with GERD symptoms and 78% of patients with erosive esophagitis have response to PPI treatment [40]. Many studies have evaluated the efficacy or superiority between different PPIs (esomeprazole, lansoprazole, pantoprazole, and rabeprazole) and, the results were inconsistent [41, 42]. …”

Section: Therapy Focused On Acid Suppressionmentioning

confidence: 99%

Current Pharmacological Management of Gastroesophageal Reflux Disease

Wang

Hsu

Wang

et al. 2013

Gastroenterology Research and Practice

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Gastroesophageal reflux disease (GERD), a common disorder with troublesome symptoms caused by reflux of gastric contents into the esophagus, has adverse impact on quality of life. A variety of medications have been used in GERD treatment, and acid suppression therapy is the mainstay of treatment for GERD. Although proton pump inhibitor is the most potent acid suppressant and provides good efficacy in esophagitis healing and symptom relief, about one-third of patients with GERD still have persistent symptoms with poor response to standard dose PPI. Antacids, alginate, histamine type-2 receptor antagonists, and prokinetic agents are usually used as add-on therapy to PPI in clinical practice. Development of novel therapeutic agents has focused on the underlying mechanisms of GERD, such as transient lower esophageal sphincter relaxation, motility disorder, mucosal protection, and esophageal hypersensitivity. Newer formulations of PPI with faster and longer duration of action and potassium-competitive acid blocker, a newer acid suppressant, have also been investigated in clinical trials. In this review, we summarize the current and developing therapeutic agents for GERD treatment.

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Section: Therapy Focused On Acid Suppressionmentioning

confidence: 99%

Current Pharmacological Management of Gastroesophageal Reflux Disease

Wang

Hsu

Wang

et al. 2013

Gastroenterology Research and Practice

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Stretta radiofrequency treatment vs Toupet fundoplication for gastroesophageal reflux disease: a comparative study

Liu

et al. 2020

BMC Gastroenterol

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Background: Outcomes of gastroesophageal reflux disease (GERD) using Toupet fundoplication (TF) and Stretta radiofrequency (SRF) have not been compared and this study was conducted to compare therapeutic efficacy of the two methods. Methods: This retrospective study analyzed a total of 230 patients undergoing TF or SRF at our hospital. Baseline data, reflux symptoms, the DeMeester scores, lower esophageal sphincter (LES) pressure and adverse events were compared over 1 year period. Results: A total of 226 patients were included in the study. The time and frequency of reflux and percentage of reflux time before and 12 months after therapy were not significantly different. There were significantly interactions between the therapy method and follow-up time on the DeMeester score and LES pressure. Twelve months post therapy, the DeMeester score was significantly higher in SRF than in TF group, while the LES pressure was lower. At 12 months after therapy, multivariate Cox proportional regression analysis showed that reflux frequency, the DeMeester score and LES pressure were risk factors for poor prognosis in TF group, while reflux frequency and the DeMeester score, and LES pressure were risk factors for poor prognosis in SFR group. Conclusions: Compared with TF, SFR can significantly improve the esophageal pH and pressure in GERD patients without increasing the risk of poor prognosis.

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Doença do refluxo gastroesofágico: tratamento farmacológico

Cited by 2 publications

References 83 publications

Current Pharmacological Management of Gastroesophageal Reflux Disease

Current Pharmacological Management of Gastroesophageal Reflux Disease

Stretta radiofrequency treatment vs Toupet fundoplication for gastroesophageal reflux disease: a comparative study

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