Risco de distúrbio glicêmico em mulheres idosas ajustado por antropometria e genótipos de citocinas

Ferreira, Aparecido Pimentel; Ferreira, Cristiane Batisti; Souza, Vinícius Carolino; Furioso, Audrey Cecília Tonet; Toledo, Juliana Oliveira; Moraes, Clayton Franco; Córdova, Cláudio; Nóbrega, Otávio Tolêdo

doi:10.1590/s0104-42302011000500016

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…Findings were also consistent with the limited available prior research from Brazil. For example, one study, which was conducted at an outpatient clinic in Sao Paulo, indicated that respondents with CU reported via the Dermatology Life Quality Index (DLQI) a negative impact on their ability to participate in daily and leisure activities, as well as experiencing uncomfortable symptoms (e.g., itching) and feelings of embarrassment from their condition [ 30 ]. Another study conducted in a Sao Paulo outpatient clinic assessed HRQoL using the SF-36 domain scores and the DLQI [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

The Burden of Chronic Urticaria from Brazilian Patients’ Perspective

Balp

Silva²,

Vietri

et al. 2017

Dermatol Ther (Heidelb)

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IntroductionChronic urticaria (CU), a proxy for chronic spontaneous urticaria, has been associated with a negative impact on health-related quality of life (HRQoL) and costs, but there is limited evidence on the burden of CU in Brazil. The objective of this study was to estimate the prevalence of CU and assess the burden of CU on HRQoL and healthcare resource utilization (HRU) among adults in Brazil.MethodsThis retrospective, cross-sectional study, pooled data from the 2011, 2012, and 2015 National Health and Wellness Survey in Brazil (n = 36,000). Respondents (aged ≥18 years) diagnosed with and treated for CU provided data on demographics, health history, HRQoL (mental and physical health status) on Short-Form SF-36v2, presence of psychological complaints, work impairment, activity impairment, and HRU. Generalized linear models, controlling for covariates, examined differences between those treated for CU and matched controls on the outcome variables.ResultsThe prevalence of diagnosed CU was 0.41% (n = 249) and treated CU was 0.21% (n = 127). After adjustments, CU (currently treated for CU) was associated with worse mental functioning, physical functioning, and health utilities compared with controls (all p < 0.01). CU had over twice the odds of anxiety and sleep difficulties, over 1.5 times the work and activity impairment, twice the number of total physician visits, eight times the number of allergist visits, and twice the number of emergency room visits as controls (all p < 0.01).ConclusionsMany CU patients using prescription treatment experienced anxiety and sleep disturbances, poorer HRQoL, significant work and activity impairment, and high HRU, compared with matched general population controls. Findings suggest an unmet need for more effective treatment and management of CU in Brazil.FundingNovartis Pharma AG and Genentech.

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Section: Discussionmentioning

confidence: 99%

The Burden of Chronic Urticaria from Brazilian Patients’ Perspective

Balp

Silva²,

Vietri

et al. 2017

Dermatol Ther (Heidelb)

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“…7,8 In humans, diminished NO production has been associated with insulin-resistant status, such as type 2 diabetes mellitus, obesity, hypertension, and dyslipidemia. [9][10][11] Several single-nucleotide polymorphisms (SNPs) have been explored by observational studies throughout the globe on the subject of insulin resistance, 12,13 and based on the contribution of these, systematic reviews and meta-analysis studies can be built. No genome-wide study has so far addressed the genetics of glycemic homeostasis in the immediate post-MI phase.…”

Section: Introductionmentioning

confidence: 99%

Defective Allele of the Neuronal Nitric Oxide Synthase Gene Increases Insulin Resistance During Acute Phase of Myocardial Infarction

Nóbrega¹,

Campos-Staffico²,

Oliveira³

et al. 2021

IJGM

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Background: Glycemic disorders are strong predictors of mortality in ST-elevation myocardial infarction (STEMI) patients, and disruption in nitric oxide (NO) production is associated with insulin-resistant states. We evaluated whether a defective allele of the neuronal nitric oxide synthase (nNOS) gene (NOS1) might influence insulin response and blood-glucose balance during the acute phase of STEMI and if post-infarction total plasma-NO levels and vasodilation scores varied across nNOS genotypes. Methods: Consecutive patients with STEMI (n=354) underwent clinical evaluations and genotyping for the promoter variation rs41279104. In-hospital clinical and blood evaluations were performed at admission and five days after STEMI, with glycemic, insulinemic, and disposition indices assessed at the same times. Flow-mediated dilation (FMD) was assessed by reactive hyperemia on the 30th day. Results: Homozygotes for the defective allele (A) showed lower glycemia and insulin sensitivity on day 1 while showing the highest β-cell function and no changes in the circulating NO pool, which is compatible with hyperresponsive β cells counteracting the inherent glucoseresistant state of AA patients. At day 5, glycemic scores had shifted to indicate greater insulin sensitivity among A homozygotes, paralleled by a significant yet poor increase in NO bioavailability compared to that among G carriers. All in all, defective homozygotes showed greater insulin resistance at admission that had reversed by 5 days after STEMI. Even so, A carriers developed lower FMD scores compared to G homozygotes after the acute phase. Conclusion:A defective nNOS allele (and due decline in NO production) seemed to elicit a hyperinsulinemia response to compensate for an insulin-resistant state during the acute phase of STEMI and to be associated with poor endothelial function after the acute phase.

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Association of IL-6, TNF-α and IL-10 gene polymorphisms with type 2 diabetes mellitus

2013

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Type 2 diabetes mellitus (T2DM) is a metabolic pro-inflammatory disorder characterized by chronic hyperglycemia and increased levels of circulating cytokines suggesting a causal role of inflammation in its etiology. Polymorphism of cytokine genes including interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α) and interleukin-10 (IL-10) were studied in T2DM patients as well as in normal healthy controls. Genomic DNA was isolated from both T2DM patients and controls followed by quantification and genotyping by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) using suitable primers. The genotypic, allelic and carriage rate frequency distribution in patients and controls were analyzed by SPSS (version 15.0). Odd ratios with 95 % confidence interval was determined to describe the strength of association by logistic regression model. Double and triple combinations of genotypes were analyzed by χ(2) test. Gene-gene interaction and linkage disequilibrium tests were performed using SHEsis software. Individually, IL-6, TNF-α and IL-10 did not show any association. In double combination, IL-6 -597 GA and TNF-α -308 GG genotypes increased the risk up to 21 times and in triple combination IL-6 -597 AA, TNF-α -308 GG and IL-10 -592 CA increased the risk of T2DM up to 314 times. In gene-gene interaction allele 'A' of all studied polymorphisms increased the risk of T2DM up to 1.41 times. Our results suggest that individuals having a haplotype combination of AA, GG and CA for IL-6, TNF-α and IL-10 gene polymorphisms will have higher susceptibility and be at greater risk of developing T2DM.

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Risco de distúrbio glicêmico em mulheres idosas ajustado por antropometria e genótipos de citocinas

Abstract: Our results suggest that bearing the A allele of the -308 G > A polymorphism of TNF-α predisposes to anthropometric measure-sensitive impaired glucose metabolism in older women.

Cited by 6 publications

References 23 publications

The Burden of Chronic Urticaria from Brazilian Patients’ Perspective

The Burden of Chronic Urticaria from Brazilian Patients’ Perspective

Defective Allele of the Neuronal Nitric Oxide Synthase Gene Increases Insulin Resistance During Acute Phase of Myocardial Infarction

Association of IL-6, TNF-α and IL-10 gene polymorphisms with type 2 diabetes mellitus

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