Cystatin C and inflammatory markers in kidney transplant recipients

Revista da Associação Médica Brasileira

França²,

Cabral³

et al. 2013

Section: Discussionsupporting

confidence: 70%

Cystatin C, kidney function, and cardiovascular risk factors in primary hypertension

Revista da Associação Médica Brasileira

França²,

Cabral³

et al. 2013

“…From our perspective, this association is expected, as inflammation is activated in early phases of renal disease [2]. Moreover, as we have previously addressed, cystatin C is a sensitive marker of small reductions in renal function that may identify a preclinical stage of kidney disease [35,36]. In this context, we believe that cystatin C could directly reflect this association with more sensitivity than serum creatinine or estimated creatinine clearance [2].…”

Section: Cystatin C Inflammation and Early Kidney Dysfunctionmentioning

confidence: 77%

How to understand the association between cystatin C levels and cardiovascular disease: Imbalance, counterbalance, or consequence?

Souza

2013

Journal of Cardiology

Self Cite

The association of cystatin C with renal function has been studied for more than 25 years. Cystatin C has been described to have a better diagnostic performance than creatinine to assess renal function, particularly to detect small reductions in glomerular filtration rate. Recently, cystatin C has emerged as a strong predictor of incident or recurrent cardiovascular events and adverse outcomes in patients without kidney disease. Furthermore, it has been suggested that cystatin C concentrations are directly related to both inflammation and atherosclerosis. Nevertheless, the link between inflammation, atherogenesis, cardiovascular risk, and cystatin C is still poorly understood. This brief report discusses recent data, contrasting findings and possible mechanisms involved in this interaction.

“…Kidney transplantation is the preferred medium of renal replacement therapy in patients with end-stage renal disease (ESRD). It offers better quality of life and longevity to patients [1]. Nevertheless, renal transplantation harbors a risk of graft loss.…”

Section: Introductionmentioning

confidence: 99%

Changes of serum Amyloid-A (SAA), tumor necrosis factor-a (TNF-a), c-reactive protein (CRP) and association of CRP with cystatin-c in kidney transplantation

Gompou,

Perrea,

Karatzas

et al. 2023

Hematol Med Oncol

Objective: This study was performed to determine whether renal function and graft origin affect serum levels of tumor necrosis factor-a (TNF-a), serum amyloid A (SAA) and C-reactive protein (CRP), among individuals having undergone renal transplantation (Tx). Methods:In a sample of fifty kidney recipients, serum creatinine (Cr), SAA, TNF-α and CRP were quantitatively determined at several time-points, pre-and post-Tx (2nd, 6th, 14th day, 3 months post-Tx). Patients were grouped as follows: those presenting restored renal function (<1.5mg/dl three months post-Tx) versus those with mild renal dysfunction (>1.5mg/dl three months post-Tx), patients having received allograft from living donors versus patients having received cadaveric grafts.Results: A total of 32 participants received grafts from living donor while 18 received cadaveric transplants. Two evenly numbered groups (N=25) were formed according to the presence of mild renal dysfunction. The differences of SAA values between those with and without restored renal function, as well as between living versus cadaveric graft recipients, were not significant at any time point. Similarly, no disparities were detected in TNF-a levels, between patients with serum Cr<1.5mg/dl and those with Cr>1.5mg/dl, or between recipients of living and cadaveric donors. Finally, serum CRP levels were homogeneous in individuals with and without mild renal dysfunction, as well as in patients receiving grafts from living and cadaveric donors throughout the three-month follow-up. In an exploratory analysis, serum CRP and cystatin-c were not correlated, at any of the time-points.Conclusions: SAA, TNF-α and CRP are not differentiated by renal function and graft origin after renal transplantation.