Células glandulares atípicas e câncer de colo uterino: revisão sistemática

Abstract

Atypical glandular cells are a common finding in cervical cytology in cervical cancer screening and its occurrence has increased in the last decades. The identification of these cells is clinically very important due to its association with cervical and endometrial dysplasic lesions and cancer. Using a systematic approach, this article reviewed studies investigating cervical lesions that are characteristic in patients previously diagnosed as having atypical glandular cells. Studies in which diagnostic investigation did not include histopathological diagnosis were excluded. A comprehensive search for available material in LILACS, SciELO, PubMed/ Medline and Old Medline databases, dated between 1966 and 2009 was performed. Articles omitted by the electronic database search were also included. Nineteen articles met the inclusion criteria and were selected. This report aims at evaluating whether atypical glandular cells, initially found in cervical cytology and subsequently identified at the histological analysis, are related to the presence of benign, pre-malignant and malignant lesions. Eleven out of 19 selected articles showed the highest correlation between atypical glandular cells with benign diseases and six with squamous pre-malignant lesions.

Underscreened Women Remain Overrepresented in the Pool of Cervical Cancer Cases in Spain: A Need to Rethink the Screening Interventions

“…Despite small numbers (3/75), AGC was only seen in the ADC group and all of them had been diagnosed within the 3-year screening interval. Cytologies classified as AGC, although relatively uncommon, are likely to be a reliable marker of cancer varying the incidence of cases from 0.05% to 2.1 [ 41 ] suggesting that immediate colposcopy referral is probably the best option for these women [ 39 , 41 ].…”

Evaluation of DNA from the Papanicolaou Test to Detect Ovarian and Endometrial Cancers

“…An important observation that inspired the current study is that asymptomatic women occasionally present with abnormal glandular cells (AGCs) detected in a cytology specimen as part of their routine cervical cancer screening procedure. Although AGCs are associated with pre-malignant or malignant disease in some cases (20–24), it is often difficult to distinguish the AGCs arising from endocervical, endometrial, or ovarian cancer from one another and from more benign conditions.…”

Histological follow-up in patients with atypical glandular cells on Pap smears

“…[ 1 ] According to the literature, glandular cell abnormalities are found in <1% of cervical cytology samples and atypical glandular cell (AGC) incidence varies from 0.1 to 2.1% in the literature. [ 2 3 ] AGCs are defined as cells that demonstrate changes beyond those encountered in benign reactive processes, still are not sufficient for the diagnosis of adenocarcinoma. [ 4 ] Although these cells usually originate from the glandular epithelium of the endocervix or endometrium, they may originate from various locations such as salpinges, ovary, or other intraperitoneal organs.…”