Paquidermoperiostose associada à neoplasia gástrica

Fortes, Bibiana Callegaro; Dotta, Gabriel; Copês, Rafaela Martinez; Valentini, Rafael; Silva, João Carlos Nunes da; Monticielo, Odirlei André

doi:10.1590/s0104-42302011000200004

Cited by 2 publications

(4 citation statements)

References 16 publications

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“…In our study, we systematically revealed the gastric mucosa hyperplasia in all of eight PDP patients. We believe that the incidence of digestive system abnormities in PDP, especially the gastric mucosa hyperplasia, is much higher than it have been reported 20 . So gastric mucosa hyperplasia could be regarded as a common manifestation of PDP and related examinations were advised in every PDP patient.…”

Section: Discussionmentioning

confidence: 54%

“…What’s more, this would suggest an increased risk of gastric cancer in PDP patients. And PDP patients do tend to develop gastric tumor at a relatively young age 17 , 20 , 39 , 40 . Therefore, it is possible that high PGE 2 level in PDP patients might result in gastric mucosa hyperplasia even hyperplasic tumor in a similar way.…”

Section: Discussionmentioning

confidence: 99%

“…performed gastroscopy examination in 21 of 76 PDP patients (27.6%) and they found all of these patients had ulcer or hypertrophic gastritis 19 . In 2011, according to Fortes BC’s summary, more than 20% PDP patients present gastric system abnormities 20 .…”

Section: Introductionmentioning

confidence: 99%

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Interleukin-6, tumor necrosis factor-alpha and receptor activator of nuclear factor kappa ligand are elevated in hypertrophic gastric mucosa of pachydermoperiostosis

Huang

Wang

Cao

et al. 2017

Sci Rep

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Pachydermoperiostosis (PDP) is a rare inherited multisystem disease characterized with digital clubbing, pachydermia and periostosis. Variants in either HPGD or SLCO2A1 that interrupt the prostaglandin E2 (PGE2) pathway have been shown to be involved in PDP. Here, in addition to six confirmed variants in HPGD or SLCO2A1, we identified four novel SLCO2A1 variants in eight PDP patients from seven Chinese Han families. In addition, gastric mucosa hyperplasia was observed in all affected individuals and interleukin-6 (IL-6), tumor necrosis factor-alpha (TNFα) and receptor activator of nuclear factor kappa ligand (RANKL) expression were elevated in hypertrophic gastric mucosa. Two of eight patients who had severe arthralgia were treated with celecoxib. After three months, their arthralgia was partly relieved and IL-6, TNFα and RANKL expression were decreased in accordance with their relieved hypertrophic gastric mucosa. Our study broadens the variation spectrum of SLCO2A1 and suggests that the gastric mucosa hyperplasia might be a common characteristic of PDP. Moreover, celecoxib would be a considerable choice for PDP patients. We also revealed that IL-6, TNFα and RANKL may play important roles in the molecular mechanisms of gastric mucosa hyperplasia in PDP for the first time.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

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Interleukin-6, tumor necrosis factor-alpha and receptor activator of nuclear factor kappa ligand are elevated in hypertrophic gastric mucosa of pachydermoperiostosis

Huang

Wang

Cao

et al. 2017

Sci Rep

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“…Com o significativo aumento de estudantes no ensino superior, começase a realizar mais estudos voltados à saúde mental dos estudantes. Galdino Loreto (1985) foi pioneiro a estudar a saúde mental dos universitários no Brasil em 1958, outras contribuições científicas também discutiram o tema, como Fortes (1972), Albuquerque (1973) e Giglio (1976), Castro (2017) que em seu estudo reforçou sua percepção de que as instituições de ensino superior são ambientes de risco à saúde mental e problematizou a falta de estudos voltadas a esta temática.…”

Section: Referencial Teóricounclassified

Mental health among undergraduate psychology students from a private university in Southern Brazil

Feijó,

Silva,

Martini

et al. 2023

CLIUM

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The literature indicates that there are stressful events that accompany the initial and final courses of undergraduate studies, which can result in symptoms of stress, mental exhaustion, anxiety, depression, and the prevalence of common mental disorders. In view of this, the present study is a qualitative and descriptive research aimed at assessing the mental health of students in the initial course and the final course of the Psychology undergraduate program at a private university in the southern region of the country. A total of 68 students were interviewed, with 50 in the first semester and 18 in the final semester of the program. Data collection involved a sociodemographic questionnaire, the Subjective Well-being Scale, and the Clinical Outcome Routine Evaluation - Outcome Measure. The results indicate high levels of anxiety and insecurity among psychology students, as well as low levels of interest, joy, attention, engagemen, enthusiasm, disposition, productivity, and well-being.

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Paquidermoperiostose associada à neoplasia gástrica

Cited by 2 publications

References 16 publications

Interleukin-6, tumor necrosis factor-alpha and receptor activator of nuclear factor kappa ligand are elevated in hypertrophic gastric mucosa of pachydermoperiostosis

Interleukin-6, tumor necrosis factor-alpha and receptor activator of nuclear factor kappa ligand are elevated in hypertrophic gastric mucosa of pachydermoperiostosis

Mental health among undergraduate psychology students from a private university in Southern Brazil

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