Análise dos genes GSTM1 e GSTT1 em pacientes com câncer de cabeça e pescoço

Leme, Cássia Veridiana Dourado; Raposo, Luis Sérgio; Ruiz, Mariana Torreglosa; Biselli, Joice Matos; Galbiatti, Ana Lívia Silva; Maníglia, José Victor; Pavarino, Érika Cristina; Goloni-Bertollo, Eny Maria

doi:10.1590/s0104-42302010000300013

Cited by 24 publications

(11 citation statements)

References 30 publications

(48 reference statements)

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“…Toxicity rates showed no difference between the three groups. Leme et al48 endeavored to establish the clinical and demographic profile and identify risk factors among patients with head and neck cancer and relate them to the polymorphism of GSTT1 and GSTM1. An association was established between GSTM1 null genotypes and head and neck cancer.…”

Section: Reviewmentioning

confidence: 99%

An overview of recently published medical papers in Brazilian scientific journals

Silva

Gomes

2011

Clinics

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A brief review intended as information to the readership of Clinics on papers recently published under various medical headings in Brazilian scientific journals recently indexed or about to be indexed in ISI-THOMSON Journal Citation Reports. Journals covered in this review are Acta Ortopédica Brasileira, Arquivos Brasileiros de Cardiologia, Jornal Brasileiro de Pneumologia, Revista Brasileira de Cirurgia Cardiovascular and Revista da Associação Médica Brasileira.

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Section: Reviewmentioning

confidence: 99%

An overview of recently published medical papers in Brazilian scientific journals

Silva

Gomes

2011

Clinics

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“…Some studies in Oncology have assessed the predisposition of individuals to the onset of cancer [28][29][30] , which can even predispose them to the recurrence of it, with or without treatment. In the literature, cases of genetic predisposition to cancer of the head and neck areas is not well observed, but cases of genetic alteration acquired through the association of behavioral habits, such as tobacco use 29,31 , alcohol consumption 29,31 , viruses such as HPV 32,33 and even the consumption of red meat 34 . Such findings show that the prevention of this type of cancer becomes more feasible by combating and controlling factors related to habits and associated factors susceptible to intervention.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with lip and oral cavity cancer

Ribeiro

Medeiros

Rodrigues

et al. 2015

Rev. bras. epidemiol.

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ABSTRACT:Purpose: This study aimed to identify factors associated with the occurrence of primary cancer of the lip and oral cavity regions compared to other types of head and neck cancers according to demographic, socioeconomic data and lifestyle, in Brazil, from 2000 to 2011. Methods: A study was conducted using Hospital Cancer Records (Instituto Nacional do Câncer), from 2000 to 2011, totaling 23,153 cases. Data were analyzed by binary logistic regression (response category: primary cancers located in the lip and oral cavity; comparison category; other types of primary cancer in the head and neck, which does not affect the lip and oral cavity) at a significance level α = 5%. Results: The study showed factors associated with higher incidence of cancer in the lip and oral cavity: being of advanced age (OR = 1.16), not having a family history of cancer (OR = 2.38), alcohol consumption (OR = 1.17); former tobacco use (OR = 1.51) or current tobacco use (OR = 1.65); having a previous diagnosis of cancer without treatment (OR =1.66). Being female (OR = 0.92), having completed basic (OR = 0.71) and higher (OR = 0.46) education and having previous diagnosis of cancer with treatment (OR = 0.74) constituted factors associated with lower prevalence of cancer of the lip and oral cavity. Conclusion: Age, absence of family history of cancer, smoking habits and alcohol consumption, and previous diagnosis of cancer without treatment were associated with a higher incidence of cancer of the lip and oral cavity.

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“…Tobacco contains many carcinogenic substances, such as nitrosamines and aromatic hydrocarbons, which interact with the genetic material of the cells resulting in DNA adducts, which in turn favor the occurrence of mutations that drive the carcinogenic process. Chemical substances present in tobacco are metabolized by enzymes from the P450 cytochrome family and glutathione-S-transferases (GSTT1 and GSTM1) (Leme et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Glutathione-S-transferases (GST) are a family of enzymes involved in the detoxification of xenobiotics, such as the polycyclic aromatic hydrocarbons present in cigarettes, hence protecting cells from deleterious and oxidative effects (Joseph et al, 2006;Singh et al, 2008;Leme et al, 2010). The homozygous deletion or null genotype of GSTM1 and GSTT1 results in reduction or absence of the activities of these enzymes, with the possibility of increasing susceptibility to cancer (Joseph et al, 2006;Singh et al, 2008;Leme et al, 2010). The genes that code these enzymes are highly polymorphic and show great variability of expression levels and activity (Leme et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Research Article Null polymorphisms in <i>GSTT1</i> and <i>GSTM1</i> genes and their associations with smoking and cervical cancer

Tacca¹,

Lopes²,

Vilanova-Costa³

et al. 2019

Genet. Mol. Res.

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Human papillomavirus (HPV) infection is the main risk factor for cervical cancer. Other risk factors include smoking and genetic susceptibility. Glutathione-S-transferases (GST) are enzymes involved in tobacco carcinogen metabolism, and genes encoding these enzymes are highly polymorphic. We compared the frequencies of GSTM1 and GSTT1 null polymorphisms in women with cervical cancer and in a control group, as well as to determine possible associations between such polymorphisms, cigarette smoking and the prognosis of cervical cancer. The series comprised 135 cervical cancer patients and 100 women without cancer. Genotypes were ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 18 (1): gmr18067 A.L.M. Tacca et al. 2 investigated by PCR. The results were compared using the Chisquare test or Fisher's exact test, and survival analysis by Kaplan-Meier test and Log-rank. Among the cases, the frequency of GSTM1 gene null polymorphism was 22.2%, and for the GSTT1 gene it was 48.5%. Among the controls, the frequency of the GSTM1 gene null polymorphism was 45.0%, while for GSTT1 it was 56.0%. A significant association was found between smoking and cervical cancer (P= 0.0062; OR = 2.16). Differently from GSTM1, the GSTT1 null polymorphism was not associated with cervical cancer risk in this study. The GSTT1 null genotype was significantly associated with worse prognosis. The overall survival rate for the cervical cancer group was 78.5%, and when stratified by genotypes, survival was higher in patients presenting at least one of the alleles, GSTT1 or GSTM1, indicating a higher risk of death for those presenting dual nullity (P= 0.031; RR = 2.458).

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Análise dos genes GSTM1 e GSTT1 em pacientes com câncer de cabeça e pescoço

Cited by 24 publications

References 30 publications

An overview of recently published medical papers in Brazilian scientific journals

An overview of recently published medical papers in Brazilian scientific journals

Factors associated with lip and oral cavity cancer

Research Article Null polymorphisms in <i>GSTT1</i> and <i>GSTM1</i> genes and their associations with smoking and cervical cancer

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