Efeito da suplementação com vitamina A sobre a concentração de retinol no colostro de mulheres atendidas em uma maternidade pública

Ribeiro, Karla Danielly da Silva; Araújo, Katherine Feitosa de; Dimenstein, Roberto

doi:10.1590/s0104-42302009000400022

Cited by 12 publications

(12 citation statements)

References 27 publications

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“…In the present study, retinol concentrations in the colostrum were compatible with the values in the breast milk found in developing countries (2.1–3.5 μmol L −1 ) . It is expected that the VA concentrations in the colostrum are usually high , which was confirmed in the results of the present study.…”

Section: Discussionsupporting

confidence: 92%

Retinol status and associated factors in mother–newborn pairs

Bezerra

Ribeiro

Lima

et al. 2019

J Human Nutrition Diet

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Background Vitamin A deficiency is still considered to be a nutritional problem during pregnancy, lactation and early childhood. The present study aimed to assess the vitamin A status of women and their newborns in the Brazilian Northeast and to determine the association between retinol in the maternal serum, umbilical cord blood and colostrum. Methods Vitamin A status in 65 pairs of women and newborns was assessed from samples of the mother’s serum, umbilical cord serum and colostrum using high‐performance liquid chromatography. The inadequacy of the vitamin A status of mothers and infants was identified if the retinol values were <0.7 µmol L−1 in maternal serum or umbilical cord blood or <1.05 µmol L−1 in colostrum. Results The prevalence of inadequate maternal vitamin A status was 21.5% (95% CI: 11.5%–31.5%) and 13.8% [95% confidence interval (CI) = 5.4%–22.2%] based on maternal serum and colostrum, respectively. Among newborns, 41.5% (95% CI = 29.3%–53.5%) presented a low status of vitamin A based on cord serum. Multiple linear regression analysis identified that maternal serum retinol is a predictor of umbilical cord retinol (P = 0.005). Retinol in maternal serum was lower in mothers who were less educated (P = 0.04) and colostrum retinol was higher in older (P = 0.04) and multiparous (P = 0.002) mothers. Conclusions Vitamin A deficiency is a common problem among mothers attended in public hospitals in Northeast Brazil and maternal retinol concentrations are associated with retinol status in newborns. Maternal age, parity and educational level were related to the maternal vitamin A status.

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Section: Discussionsupporting

confidence: 92%

Retinol status and associated factors in mother–newborn pairs

Bezerra

Ribeiro

Lima

et al. 2019

J Human Nutrition Diet

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“…Regarding the biochemical analysis, the colostrum retinol found for healthy puerperal women was similar to those found in the literature (Ribeiro et al 2009, Szlagatys-Sidorkiewicz et al 2012. However, there are not studies with the same characteristics in puerperal women with diabetes.…”

Section: Discussionsupporting

confidence: 82%

Gestational diabetes: a risk of puerperal hypovitaminosis A?

Resende

Lira

Grilo

et al. 2015

An. Acad. Bras. Ciênc.

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The influence of gestational diabetes on vitamin A deficiency in lactating women and, consequently, in their newborn has been verified through a cross-sectional case-control study conducted with volunteer puerperal women. The control group consisted of healthy women and the test group was composed of women with gestational diabetes. One hundred and seven women were recruited, corresponding to 71 controls and 36 cases. Personal, gestational and newborn data were collected directly from medical records during hospitalization. The retinol was determined in maternal colostrum and serum by High Performance Liquid Chromatography. Postpartum women with gestational diabetes were older, had more children and a higher prevalence of cesarean delivery. No difference was found in retinol concentration in maternal milk and serum between the groups. However, it was observed that 16.7% had vitamin A deficiency in the group of patients with diabetes and only 4.1% had such deficiency in the control group. Although no difference was found in colostrum and serum retinol concentration between women with and without gestational diabetes, the individual analysis shows that those with diabetes are at higher risk of being vitamin A deficient.

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“…26 O aleitamento materno é um importante fator de proteção contra a deficiência de vitamina A nos primeiros anos de vida. 22,26,27 No entanto, no presente estudo, não houve associação significante entre a hipovitaminose A e o tempo de exposição ao aleitamento materno. Embora não se disponham de informações quanto ao estado nutricional de vitamina A materno na região estudada, pode-se especular que as mães investigadas, tal como suas crianças, apresentem altas prevalências de deficiência de retinol.…”

Section: Discussionunclassified

Fatores associados à hipovitaminose A em crianças menores de cinco anos

Ferreira

Moura

Assunção

et al. 2013

Rev. Bras. Saude Mater. Infant.

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OBJETIVOS: identificar os fatores associados à hipovitaminose A em crianças da região semiárida de Alagoas. MÉTODOS: estudo transversal com amostra probabilística de 551 crianças menores de cinco anos. Os níveis séricos de retinol foram aferidos usando-se cromatografia líquida de alta eficiência. Na identificação da associação entre as variáveis independentes e hipovitaminose A (retinol <20 µg/dL) utilizou-se a razão de prevalência (RP) e respectivo IC95% calculados por regressão de Poisson com ajuste robusto da variância, tanto na análise bruta quanto na ajustada. Nesta, foram incluídas todas as variáveis que naanálise bruta atingiram p<0,1. Associações foram consideradas estatisticamente significantes quando p<0,05. RESULTADOS: a prevalência de hipovitaminose A foi de 45,4% e as variáveis que se mantiveram associadas após análise multivariável foram a baixa escolaridade materna (RP=1,66; IC95%: 1,12-2,44), obaixo peso ao nascer (RP=1,41; IC95%: 1,01-1,98) eter de 12,1 a 24 meses (RP=1,45; IC95%: 1,04-2,02). CONCLUSÕES: evidencia-se a relevância epidemiológica da hipovitaminose A em crianças do semiárido alagoano. Crianças nascidas com baixo peso, com mães de baixa escolaridade e no segundo ano de vida devem receber atenção prioritária.

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Efeito da suplementação com vitamina A sobre a concentração de retinol no colostro de mulheres atendidas em uma maternidade pública

Cited by 12 publications

References 27 publications

Retinol status and associated factors in mother–newborn pairs

Retinol status and associated factors in mother–newborn pairs

Gestational diabetes: a risk of puerperal hypovitaminosis A?

Fatores associados à hipovitaminose A em crianças menores de cinco anos

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