Insulin resistance and lipid metabolism

Ikeoka, Dimas; Krusinova, E.

doi:10.1590/s0104-42302009000300003

Cited by 10 publications

(6 citation statements)

References 2 publications

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“…Type 2 diabetes is often associated with a cluster of lipid abnormalities that are characterised by an increase in TGs, TCs, and LDLs and by a decrease in HDLs. Additionally, the combination of high TGs and low HDLs has long been described as being responsible for the high risk of cardiovascular complications [17]. Therefore, the effective control of the lipid levels in the serum of the db/db mice by the TGW extract may have important clinical significance.…”

Section: Discussionmentioning

confidence: 99%

Anti-Diabetic Effects of TongGuanWan, a Chinese Traditional Herbal Formula, in C57BL/KsJ-db/db Mice

et al. 2011

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In the present study, the anti-diabetic effects of a traditional Chinese medicinal formula extract, TongGuanWan, were investigated in type 2 diabetic animals. It was orally administered to C57BL/KsJ-db/db mice once a day for 4 weeks at the doses of 62, 125, and 250 mg/kg body weight. TongGuanWan significantly lowered the blood glucose and glycosylated haemoglobin levels as well as improved the glucose tolerance in db/db mice. The serum triglyceride levels in the db/db mice were significantly decreased, whereas the high-density lipoprotein cholesterol levels were significantly increased, after treatment with this herbal formula. TongGuanWan also markedly decreased the animals' body weights compared to those of the control db/db group but did not alter food intake. The effects of TongGuanWan were compared to those of the drug rosiglitazone. In addition, five main constituents of TongGuanWan, mangiferin, berberine, cinnamic aldehyde, timosaponin BII, and timosaponin AIII, were quantified using high performance liquid chromatography coupled with a diode array and an evaporative light scattering detector (HPLC-DAD-ELSD). These results suggest that TongGuanWan may be useful for the treatment of type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Anti-Diabetic Effects of TongGuanWan, a Chinese Traditional Herbal Formula, in C57BL/KsJ-db/db Mice

et al. 2011

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“…OPF treatment in diabetic rats ameliorated serum TG, TC values to normal levels with significant increment in HDLC values. A combination of high serum TG and low HDLC levels are regarded as a major hallmark in the development of cardiovascular complication (Ikeoka and Krusinova, 2009). The capacity of OPF to reduce TG values to normal levels and to increase HDLC values in diabetic rats minimize the risk of cardiovascular problems associated with DM.…”

Section: Groupsmentioning

confidence: 99%

O-prenylated flavonoid, an antidiabetes constituent in Melicope lunu-ankenda

George

Nair

Johnson

et al. 2015

Journal of Ethnopharmacology

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“…Insulin is a strongly anabolic hormone for protein (53), fat (54), and glycogen (55) accrual, and deficiency or resistance to insulin may also promote PEW. Insulin deprivation in patients with IDDM is associated with elevated plasma amino acid levels, increased protein turnover and protein oxidation, and negative nitrogen balance (56,57).…”

Section: Specific Contributions Of Diabetes Mellitus To Pew In Esrd Pmentioning

confidence: 99%

Effect of Diabetes Mellitus on Protein–Energy Wasting and Protein Wasting in End‐Stage Renal Disease

Noori

Kopple

2010

Seminars in Dialysis

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Protein wasting (PW) or protein-energy wasting (PEW) occurs commonly in patients with diabetes mellitus who have end-stage renal disease (ESRD) and are undergoing maintenance dialysis (MD) therapy. Some but not all studies indicate that PW or PEW is more prevalent in diabetic when compared with nondiabetic MD patients and that diabetic patients commencing maintenance hemodialysis (MHD) are more likely to lose fat-free, edema-free weight than are incident nondiabetic MHD patients. The causes of PW and PEW in diabetic MD patients are probably largely similar to those of nondiabetic MD patients. These causes include anorexia, reduced food intake, concurrent illnesses particularly when associated with inflammatory processes, physical or mental debility, removal of nutrients by dialysis procedure, acidemia, possibly physical deconditioning, and oxidant and carbonyl stress. However, diabetic MD patients are also at greater risk for PW or PEW from comorbidities related to diabetes per se. These disorders include ischemic vascular disease, hypertension, gastrointestinal dysfunction, and neuropathy. Metabolic disorders such as insulin deficiency or resistance to the actions of insulin, and elevated levels of counterregulatory hormones may also contribute to PW or PEW in diabetic MD patients. Mechanisms by which these metabolic disorders in diabetic ESRD patients may cause PW or PEW are discussed.

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Insulin resistance and lipid metabolism

Cited by 10 publications

References 2 publications

Anti-Diabetic Effects of TongGuanWan, a Chinese Traditional Herbal Formula, in C57BL/KsJ-db/db Mice

Anti-Diabetic Effects of TongGuanWan, a Chinese Traditional Herbal Formula, in C57BL/KsJ-db/db Mice

O-prenylated flavonoid, an antidiabetes constituent in Melicope lunu-ankenda

Effect of Diabetes Mellitus on Protein–Energy Wasting and Protein Wasting in End‐Stage Renal Disease

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