Toxicidade da azatioprina na doença de Crohn: incidência, abordagem e evolução

Colli, Márcia Valéria; Amaro, Thalita Amaral; Pinto, Alexandre de Rezende; Gaburri, Pedro Duarte; Chebli, Júlio Maria Fonseca

doi:10.1590/s0104-42302008000500014

Cited by 4 publications

(2 citation statements)

References 32 publications

(59 reference statements)

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“…Inflammatory bowel diseases (IBD) have in common chronic inflammation of the digestive tract, which may or may not have a cause or specific pathogen (5,7) . Its etiology is multifactorial and complex, it is believed to have genetic involvement, environmental, immune and intestinal microbiota (26,30) .…”

Section: Introductionmentioning

confidence: 99%

Positive Correlation Between Disease Activity Index and Matrix Metalloproteinases Activity in a Rat Model of Colitis

Oliveira

Cunha

Duarte

et al. 2014

Arq. Gastroenterol.

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ContextInflammatory bowel disease, including ulcerative colitis and Crohn’s disease, comprising a broad spectrum of diseases those have in common chronic inflammation of the gastrointestinal tract, histological alterations and an increased activity levels of certain enzymes, such as, metalloproteinases.ObjectivesEvaluate a possible correlation of disease activity index with the severity of colonic mucosal damage and increased activity of metalloproteinases in a model of ulcerative colitis induced by dextran sulfate sodium.MethodsColitis was induced by oral administration of 5% dextran sulfate sodium for seven days in this group (n=10), whereas control group (n=16) received water. Effects were analyzed daily by disease activity index. In the seventh day, animals were euthanized and hematological measurements, histological changes (hematoxylin and eosin and Alcian Blue staining), myeloperoxidase and metalloproteinase activities (MMP-2 and MMP-9) were determined.ResultsDextran sulfate sodium group showed elevated disease activity index and reduced hematological parameters. Induction of colitis caused tissue injury with loss of mucin and increased myeloperoxidase (P<0.001) and MMP-9 activities (45 fold) compared to the control group.ConclusionsIn this study, we observed a disease activity index correlation with the degree of histopathological changes after induction of colitis, and this result may be related mainly to the increased activity of MMP-9 and mieloperoxidase.

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Section: Introductionmentioning

confidence: 99%

Positive Correlation Between Disease Activity Index and Matrix Metalloproteinases Activity in a Rat Model of Colitis

Oliveira

Cunha

Duarte

et al. 2014

Arq. Gastroenterol.

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“…(5) Leukopenia is a major long-term adverse effect of treatment with AZA and/or MSZ. (5,6,9) Colli et al (10) reported leukopenia in 36 out of 106 (34%) patients with IBD treated with AZA, with a mean time to onset of leukopenia of 35 months after initiation of treatment. Lémann et al (11) evaluated 87 patients with long-term IBD and found a prevalence of leukopenia of 24.5%.…”

Section: ❚ Discussionmentioning

confidence: 99%

C-reactive protein levels and prevalence of leukopenia in patients with inflammatory bowel disease treated with azathioprine and/or mesalazine: a real-life study

Santos¹,

Catapani²,

Takahashi³

et al. 2022

Einstein (São Paulo)

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Objective: To examine serum C-reactive protein levels and the prevalence of leukopenia in patients with Crohn's disease or ulcerative colitis undergoing treatment with azathioprine and/ or mesalazine. Methods: Retrospective observational study based on clinical and laboratory data collected from medical records of 76 adult patients with inflammatory bowel disease treated with azathioprine, mesalazine or both. Sex, age, diagnosis, number of blood samples and elevated serum C-reactive protein levels during the follow-up period were recorded. The following variables were analyzed in terms of C-reactive protein levels and leukopenia episodes: sex, age, diagnosis of inflammatory bowel disease and type of drug. Statistical analyses included multiple logistic regression and the Fisher's exact test for qualitative variables. Results: Leukopenia was observed in 18.4% of patients and was associated with older age and higher doses of medication. In 44% of patients, C-reactive protein levels were high. However, symptoms were not associated with abnormal levels of this marker. Conclusion: Regardless of symptoms, serum C-reactive protein levels were not a reliable indicator of controlled inflammatory bowel disease. Leukopenia was independently associated with older age and higher doses of medication and is a common side effect, which should be routinely monitored.

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Drugs that act on the immune system

Aronson¹

2011

Side Effects of Drugs Annual

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Toxicidade da azatioprina na doença de Crohn: incidência, abordagem e evolução

Cited by 4 publications

References 32 publications

Positive Correlation Between Disease Activity Index and Matrix Metalloproteinases Activity in a Rat Model of Colitis

Positive Correlation Between Disease Activity Index and Matrix Metalloproteinases Activity in a Rat Model of Colitis

C-reactive protein levels and prevalence of leukopenia in patients with inflammatory bowel disease treated with azathioprine and/or mesalazine: a real-life study

Drugs that act on the immune system

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