Marcadores moleculares em câncer de mama preditivos de metástases axilares

Marinho, Vanessa Fortes Zschaber; Metze, Konradin; Sanches, Fernanda Squárcio Fernandes; Rocha, Gislene Fátima Silva; Gobbi, Helenice

doi:10.1590/s0104-42302008000300011

Cited by 9 publications

(9 citation statements)

References 23 publications

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“…Moreover, the oncogene HER2 is associated with resistance to chemotherapy and hormone therapy, increased local relapse and reduced survival of patients. Concluding, both Ki 67 protein marker and oncogene HER2 tend to indicate malignancy 27 .…”

Section: Discussionmentioning

confidence: 90%

Myiasis associated with an invasive ductal carcinoma of the left breast: case study

Rodrigues

Klemig

Cardozo

et al. 2017

Rev. Inst. Med. trop. S. Paulo

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Most breast cancers originate in the ductal epithelium and are referred to as invasive ductal carcinoma. In this study we report on the clinical procedures adopted to diagnose myiasis in association with infiltrating metastatic breast carcinoma in a female patient. A 41 years old woman came to the Federal Hospital of Andaraí complaining of intense itching, warmth, redness and hardening of the breast, which had acquired the aspect of an orange peel. A lesion in the left breast was cavitated, dimpled, had fetid odor, and had fibrotic and infected air nodules filled with exudate and Dipteran larvae. The tissue was cleaned and 33 larvae were extracted. The patient was hospitalized and received Ivermectin. Eighteen of the larvae extracted from the patient were placed in 70% alcohol, and twelve were placed in a container with sterile wood shavings under controlled conditions until they metamorphosed into adults. The taxonomic identification of the flies revealed that the culprit was Cochliomyia hominivorax. A histopathological exam conducted three months earlier had revealed infiltrating ductal carcinoma. Two months after the myiasis treatment, the breast tissue had healed. The patient had waited ten days from the onset of the myiasis to seek treatment, and that delay interfered negatively in the prognosis of both the neoplasm and the myiasis. This study is relevant to public health in view of the strong social impact of myiasis.

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Section: Discussionmentioning

confidence: 90%

Myiasis associated with an invasive ductal carcinoma of the left breast: case study

Rodrigues

Klemig

Cardozo

et al. 2017

Rev. Inst. Med. trop. S. Paulo

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“…Em 13/137 casos (9,5%), identificou-se a presença de células epiteliais metastáticas, tanto micrometástases (com dimensão entre 0,2 a 2 mm) como células tumorais isoladas (dimensão < 0,2 mm). A literatura relata taxas de detecção de micrometástases em 7% a 42% em linfonodos axilares, dependendo do método de estudo empregado (25)(26)(27)45) . Sabe-se que aproximadamente 25% dos pacientes linfonodo-negativos desenvolverão recidiva da doença e que poderiam talvez ter se beneficiado de quimioterapia adjuvante.…”

Section: Discussionunclassified

“…Em estudos imuno-histoquí-micos de patologia cirúrgica geral, habitualmente é usado maior número de anticorpos por caso, variando de 4,1 a 5,8 (3) . Para o estudo dos fatores preditivos e prognósticos, empregamos em média 3,4 anticorpos e, para avaliação do linfonodo sentinela, utilizamos o que tem sido preconizado na literatura, ou seja, apenas o anticorpo monoclonal antipancitoqueratina (25,27,49) . Dados da literatura mostram que o número de anticorpos utilizados em IHQ aplicada a lesões e tumores mamários é menor que em outras áreas da patologia (3,4,13,27,49) .…”

Section: Discussionunclassified

“…Para o estudo dos fatores preditivos e prognósticos, empregamos em média 3,4 anticorpos e, para avaliação do linfonodo sentinela, utilizamos o que tem sido preconizado na literatura, ou seja, apenas o anticorpo monoclonal antipancitoqueratina (25,27,49) . Dados da literatura mostram que o número de anticorpos utilizados em IHQ aplicada a lesões e tumores mamários é menor que em outras áreas da patologia (3,4,13,27,49) . Nossos dados estão de acordo com a maioria dos estudos que orientam realizar pelo menos avaliação com receptores hormonais e HER2 (12)(13)(14) .…”

Section: Discussionunclassified

“…O estudo imuno-histoquímico tem sido utilizado em diferentes situações da patologia mamária, sendo as mais importantes: avaliação de fatores preditivos e prognósticos do câncer de mama, pesquisa de células epiteliais metastáticas em linfonodo sentinela, diagnóstico diferencial de lesões mamárias e determinação de possível origem de neoplasias metastáticas (12,13,23,27,28,49) .…”

Section: Introductionunclassified

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Contribuição da imuno-histoquímica na avaliação de fatores prognósticos e preditivos do câncer de mama e no diagnóstico de lesões mamárias

Salles¹,

Cúrcio

Perez³

et al. 2009

J. Bras. Patol. Med. Lab.

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Objetivo: Fazer análise crítica da contribuição da imuno-histoquímica na avaliação de fatores preditivos/ prognósticos do câncer de mama, na pesquisa de micrometástases em linfonodos sentinela e no diagnóstico diferencial de lesões mamárias. Métodos: Foi realizado estudo observacional retrospectivo de todos os casos de lesões mamárias e linfonodos sentinelas submetidas a estudo imuno-histoquímico J Bras Patol Med Lab • v. 45 • n. 3 • p. 213-222 • junho 2009

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CXCL12 rs1801157 polymorphism in patients with breast cancer, hodgkin's lymphoma, and non‐hodgkin's lymphoma

Oliveira

Oda

Voltarelli

et al. 2009

Clinical Laboratory Analysis

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Chemokines and their receptors regulate the trafficking of immune cells during their development, inflammation, and tissue repair. The single-nucleotide polymorphism (SNP) rs1801157 (previously known as CXCL12-A/ stromal cell-derived factor-1 (SDF1)-3'A) in CXCL12/SDF1 gene was assessed in breast cancer, Hodgkin's lymphoma (HL), and non-Hodgkin's lymphoma (NHL), since the chemokine CXCL12, previously known as SDF1, and its receptor CXCR4 regulate leukocyte trafficking and many essential biological processes, including tumor growth, angiogenesis, and metastasis of different types of tumors. Genotyping was performed by PCR-RFLP (polymerase chain reaction followed by restriction fragment length polymorphism) using a restriction enzyme HpaII cleavage. No significant difference was observed in genotype distribution between breast cancer patients (GG: 57.3%; GA: 39.8%; AA: 2.9%) and healthy female controls (GG: 62.9%; GA: 33%; AA: 4.1%) nor between HL patients (GG: 61.1%; GA:27.8%; AA: 11.1%) and healthy controls (GG: 65.6%; GA: 28.9%; AA: 5.5%), whereas a significant difference was observed in genotype distribution between NHL patients (GG: 51.4%; GA: 47.1%; AA: 1.5%) and healthy controls (GG: 65.6%; GA: 28.9%; AA: 5.5%). Further studies will be necessary to elucidate the cancer chemokine network. However, this study suggests that CXCL12 rs1801157 polymorphism may have important implications in the pathogenesis of NHL.

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Marcadores moleculares em câncer de mama preditivos de metástases axilares

Abstract: Lymphatic and blood vessel invasion identified in H&E and IHC-stained slides are positively related to the rmetastatic status of axillary lymph nodes and are predictive of axillary lymph node metastases in breast cancer.

Cited by 9 publications

References 23 publications

Myiasis associated with an invasive ductal carcinoma of the left breast: case study

Myiasis associated with an invasive ductal carcinoma of the left breast: case study

Contribuição da imuno-histoquímica na avaliação de fatores prognósticos e preditivos do câncer de mama e no diagnóstico de lesões mamárias

CXCL12 rs1801157 polymorphism in patients with breast cancer, hodgkin's lymphoma, and non‐hodgkin's lymphoma

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