Infecção pelo vírus Epstein-Barr em pacientes com lúpus eritematoso sistêmico

Background Human herpesviruses (HHVs) are responsible for a significant number of clinical manifestations in systemic lupus erythematous (SLE) patients. The aim of this study was to determine the frequency of active HHV infections in SLE patients and correlating them with disease activity. Methods Serum samples were collected from 71 SLE patients and their DNAs were extracted and analyzed to detect HHV-DNA viruses using the nucleic acid amplification technique. Results Fifteen out of the 71 (21.1%) patients tested positive for the HHV-DNA virus. Of them, 11/15 HHV-DNA-positive patients (73.3%) had SLE activity index (SLEDAI – Systemic Lupus Erythematosus Disease Activity Index) ≥8 (p = 0.0001). Active HCMV infection was the mostly frequently observed infection, occurring in 6/15 patients (40%). The frequencies of other active viral infections were 22% for HSV-1, 16.7% for HHV-7, and 5.5% for HSV-2. Viral coinfection (two or more viruses detected in the same sample) occurred in three patients (16.7%). Active HHV infections in SLE patients are more frequent in those with active SLE (≥8), who is at high risk of HHV reactivation and HCMV disease. Conclusion Viral surveillance is important to identify active HHV infections that can cause clinical symptoms and other complication in SLE patients.

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Active human herpesvirus infections in adults with systemic lupus erythematosus and correlation with the SLEDAI score

Reis

Mudinutti

Peigo

et al. 2020

Adv Rheumatol

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Infecção pelo vírus Epstein-Barr em pacientes com lúpus eritematoso sistêmico

Abstract: Association between EBV activity and SLE was not demonstrated. This appears to indicate that persistence of infected B lymphocytes may be due to failure in the apoptosis mechanism or to the action of T cytotoxic lymphocytes, permitting evolution of SLE.

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References 14 publications

Active human herpesvirus infections in adults with systemic lupus erythematosus and correlation with the SLEDAI score

Active human herpesvirus infections in adults with systemic lupus erythematosus and correlation with the SLEDAI score

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