Neutropenia febril em pacientes com câncer de mama submetidas à quimioterapia: experiência de 12 anos

Neto, Omero Benedicto Poli; Reis, Francisco José Candido dos; Lopes, Fernando Muniz; Carrara, Hélio Humberto Angotti; Andrade, Jurandyr Moreira de

doi:10.1590/s0104-42302004000400023

Cited by 2 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Different risk factors account for the incidence and severity of chemotherapy‐induced neutropenia such as advanced age, concomitant radiotherapy and regimen with fluorouracil (Miller et al . 1981; Poli Neto et al . 2004).…”

Section: Discussionmentioning

confidence: 99%

Neutrophil count is not associated with infection episodes in breast cancer patients treated with anthracycline-based chemotherapy

Mendonça

Pereira

Silva

et al. 2009

European Journal of Cancer Care

View full text Add to dashboard Cite

The aim was to evaluate the impact of anthracycline-based chemotherapy on neutrophil count and infections in breast cancer women. The medical records of patients were retrospectively and prospectively reviewed (8-year period). Patients were grouped according to anthracyclines at different doses: (1) Scheme 1 (n = 56, 224 courses): 50-60 mg/m(2); and (2) Scheme 2 (n = 25, 100 courses): 65-75 mg/m(2), associated to cyclophosphamide and 5-fluorouracil, at 21-day intervals between courses. Neutrophil count was performed on diagnosis and 48-72 h before each chemotherapy course. Patients were followed up for neutrophil count and infection episodes for three consecutive courses. Multivariate analysis was used to determine independent factors for infection. After the first course, neutrophil count was reduced than baseline (P < 0.001) and maintained during the subsequent courses, without differences between courses or groups. There were 49 infection episodes (63.2% urinary, 18.4% neutropenic fever and 18.4% diverses), mainly between course 1-2 (39%) and course 3-4 (38%) of chemotherapy. Patients evaluated as presenting or not with infection episodes did not differ in neutrophil count. The number of chemotherapy courses (P < 0.05), but not age, neutrophil count or chemotherapy regimen, was associated with infection. We concluded that progressive chemotherapy, but not neutrophil count, was an independent factor for infection.

show abstract

Section: Discussionmentioning

confidence: 99%

Neutrophil count is not associated with infection episodes in breast cancer patients treated with anthracycline-based chemotherapy

Mendonça

Pereira

Silva

et al. 2009

European Journal of Cancer Care

View full text Add to dashboard Cite

show abstract

Sinais e sintomas de mielodepressão por quimioterapia no domicílio, entre portadoras de câncer ginecológico

et al. 2012

View full text Add to dashboard Cite

RESUMO A toxicidade hematológica decorrente do tratamento quimioterápico engloba a leucopenia, a trombocitopenia/plaquetopenia, a anemia, a depressão da medula óssea. Objetivou-se identificar sinais e sintomas de depressão de medula óssea entre portadoras de câncer ginecológico e de mama, decorrentes de tratamento quimioterápico no domicilio. Estudo quantitativo, descritivo, exploratório, transversal e prospectivo. A identificação das pacientes foi realizada no hospital e a visita domiciliar foi feita durante o tratamento. Foram acompanhadas 30 pacientes, todas residentes no município, com idades entre 18 e 71 anos (média de 51,10); 46,6% apresentavam câncer de mama, 33,3% de colo uterino, 16,6% de ovário e 3,33% de endométrio. Dentre as 30 entrevistadas, 86,6% relataram fraqueza/cansaço, 60%, dispneia e 23,3%, taquicardia. Dentre estas, 50% apresentaram anemia. No estudo, 53,3% das pacientes referiram algum processo infeccioso. Observou-se que 10% apresentavam sangramento. A assistência de enfermagem especializada, individualizada, holística e estendida ao domicilio facilita a minimização dos efeitos colaterais da quimioterapia.

show abstract

Neutropenia febril em pacientes com câncer de mama submetidas à quimioterapia: experiência de 12 anos

Abstract: The main risk factors associated with febrile neutropenia in patients with breast cancer were: chemotherapy within the first 24 hours post surgery, and concomitant chemotherapy and breast radiotherapy. As such, our study shows that these situations must be avoided.

Cited by 2 publications

References 15 publications

Neutrophil count is not associated with infection episodes in breast cancer patients treated with anthracycline-based chemotherapy

Neutrophil count is not associated with infection episodes in breast cancer patients treated with anthracycline-based chemotherapy

Sinais e sintomas de mielodepressão por quimioterapia no domicílio, entre portadoras de câncer ginecológico

Contact Info

Product

Resources

About