Diabetes mellitus tipo 1 e os anticorpos contra albumina sérica bovina

Damiani, Durval

doi:10.1590/s0104-42302004000200017

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“… 33 Increased levels of anti-BSA antibodies were found in autoimmune diseases such as inflammatory or auto-insulin-dependent diabetes mellitus, Crohn's disease and celiac disease, systemic lupus erythematosus and in healthy blood donors. 34 - 37 Therefore, despite the high specificity of serological tests today, it is recommended that the tests be improved. 38 …”

Section: Discussionmentioning

confidence: 99%

Serology with ML Flow test in health professionals from three different states of Brazil

Calado

Magnanini

Moura

et al. 2013

An. Bras. Dermatol.

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BACKGROUND In highly endemic countries, transmission and sub-clinical infection of leprosy are likely and the disease manifests itself in individuals without any known close contact with a leprosy patient. Health workers are social contacts belonging to the same network (the Health System) and some of them share the same social environment (nursing assistants) as patients with known patients and / or carriers. OBJECTIVE To identify ML Flow seropositivity among health professionals. METHODS We conducted a cross-sectional study using a serological survey with the ML Flow test in 450 health professionals (doctors, nurses and nursing assistants), in order to detect seropositivity in areas of high and low endemicity in municipalities from three Brazilian states (RJ, MS and RS). RESULTS The results showed general 16% seropositivity, higher in low endemic areas, regardless of whether there was direct care for leprosy patients. Paradoxically, a statistical association was observed between the area studied and seropositivity, as the place with the lowest endemicity (CA) had the highest seropositivity rate (p = 0.033). CONCLUSION The authors suggest these results are associated with a presence of an unspecified link to bovine serum albumin (BSA), carrier of PGL-1 in the ML Flow test, and recommend expanded seroepidemiological research utilizing tests with human and bovine albumin.

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