1999
DOI: 10.1590/s0104-42301999000100014
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Tolerância oral: uma nova perspectiva no tratamento de doenças autoimunes

Abstract: INTRODUÇÃOAs doenças autoimunes são causadas por uma resposta inadequada do sistema imune, que passa a reagir contra órgãos, tecidos ou células próprias, levando à sua destruição ou prejudicando sua função adequada. Existem mais de 40 doenças autoimunes identificadas com número considerável de pacientes acometidos 1 . Várias drogas imunossupressoras têm sido utilizadas na tentativa de controle da progressão de doenças autoimunes, sendo que entre elas a ciclofosfamida tem ação principalmente sobre linfó-citos B… Show more

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Cited by 3 publications
(3 citation statements)
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“…The same model was also used to investigate the factors that are potentially responsible for maximum immunization capacity [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55]. Our results suggest that not only antigen type but also antigen mutation can influence the durability of immunizations, indicating that the role of antigen persistence is important for prolonging immune memory.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The same model was also used to investigate the factors that are potentially responsible for maximum immunization capacity [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55]. Our results suggest that not only antigen type but also antigen mutation can influence the durability of immunizations, indicating that the role of antigen persistence is important for prolonging immune memory.…”
Section: Discussionmentioning
confidence: 99%
“…In 2009, Tarlinton et al [49] published a review paper, suggesting that the homeostasis of immune memory can only occur if new memory populations arise over others, i.e., to create dynamic equilibrium among memory cells, some need to disappear for others to arise, because the immune system has a maximum memory capacity [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55]. Choo et al, in a recent paper published in The Journal of Immunology [57], reported the same finding, based on the Ag-independent premise.…”
Section: Discussionmentioning
confidence: 99%
“…tecido linfoide associado à mucosa brônquica) e de outros tecidos linfoides associados com os sistemas lacrimal, mamário, glandular, gênito-urinário, cutâneo e outros 124 .…”
Section: Indução De Tolerância Periférica Pela Via Das Mucosasunclassified