Conhecimentos, atitudes e práticas de agricultores familiares brasileiros sobre a exposição aos agrotóxicos

Buralli, Rafael Junqueira; Ribeiro, Helena; Leão, Renata Spolti; Marques, Rejane C.; Silva, Daniele Santos; Guimarães, Jean Rémy Davée

doi:10.1590/s0104-12902021210103

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…Although the use of pesticides has been widespread in Brazil since the 1960s, the exact data concerning pesticide consumption from small-scale farmers are scarce (5)(6)(7). Improper pesticide application associated with farmers' limited knowledge regarding its harmful effects and poor adherence to safety precautions, such as the correct use of personal protective equipment, represent a considerable health risk for chronically exposed populations (8,9).…”

Section: Introductionmentioning

confidence: 99%

Somatic DNA Damage Response and Homologous Repair Gene Alterations and Its Association With Tumor Variant Burden in Breast Cancer Patients With Occupational Exposure to Pesticides

et al. 2022

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Homologous recombination is a crucial pathway that is specialized in repairing double-strand breaks; thus, alterations in genes of this pathway may lead to loss of genomic stability and cell growth suppression. Pesticide exposure potentially increases cancer risk through several mechanisms, such as the genotoxicity caused by chronic exposure, leading to gene alteration. To analyze this hypothesis, we investigated if breast cancer patients exposed to pesticides present a different mutational pattern in genes related to homologous recombination (BRCA1, BRCA2, PALB2, and RAD51D) and damage-response (TP53) concerning unexposed patients. We performed multiplex PCR-based assays and next-generation sequencing (NGS) of all coding regions and flanking splicing sites of BRCA1, BRCA2, PALB2, TP53, and RAD51D in 158 unpaired tumor samples from breast cancer patients on MiSeq (Illumina) platform. We found that exposed patients had tumors with more pathogenic and likely pathogenic variants than unexposed patients (p = 0.017). In general, tumors that harbored a pathogenic or likely pathogenic variant had a higher mutational burden (p < 0.001). We also observed that breast cancer patients exposed to pesticides had a higher mutational burden when diagnosed before 50 years old (p = 0.00978) and/or when carrying BRCA1 (p = 0.0138), BRCA2 (p = 0.0366), and/or PALB2 (p = 0.00058) variants, a result not found in the unexposed group. Our results show that pesticide exposure impacts the tumor mutational landscape and could be associated with the carcinogenesis process, therapy response, and disease progression. Further studies should increase the observation period in exposed patients to better evaluate the impact of these findings.

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Section: Introductionmentioning

confidence: 99%

Somatic DNA Damage Response and Homologous Repair Gene Alterations and Its Association With Tumor Variant Burden in Breast Cancer Patients With Occupational Exposure to Pesticides

et al. 2022

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O Conto da maçã envenenada: Trabalhadores brasileiros morrem diariamente por exposição intensa a agrotóxicos / The Tale of the Poisoned Apple: Brazilian Workers die daily from intense exposure to pesticides

Ribeiro¹,

Silva²

2022

IDonline

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Resumo:Nos últimos anos, o Governo Federal Brasileiro ampliou o acesso a venenos por meio de suas políticas de comodities, apoiando o grande agronegócio e desfavorecendo, em uma relação inversamente proporcional, a saúde e o bem-estar dos trabalhadores. Pontuamos que os agrotóxicos representam uma grande variedade de produtos químicos apresentados em diferentes formulações e concentrações e utilizados em diferentes ambientes: agricultura, banho sanitário animal, uso doméstico e controle de vetores. Propomos uma reflexão, que acreditamos urgente. Uma modificação na atenção à saúde dos povos, direcionada a uma agricultura familiar orgânica, livre de venenos ou com a devida fiscalização legal quanto às normas de aplicação, somado-se a uma revisão das permissões legais para uso de pesticidas.Palavras-chave: Agrotóxicos. Agricultura familiar. Fiscalização legal. Abstract: In recent years, the Brazilian Federal Government has expanded access to poisons through its commodity policies, supporting large agribusiness and disfavoring, in an inversely proportional relationship, the health and well-being of workers. We point out that pesticides represent a wide variety of chemical products presented in different formulations and concentrations and used in different environments: agriculture, animal sanitary bath, domestic use and vector control. We propose a reflection, which we believe is urgent. A change in people's health care, aimed at organic family farming, free of poisons or with due legal supervision regarding the application rules, added to a review of the legal permissions for the use of pesticides.Keywords: Pesticides. Family farming. Legal oversight.

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Conhecimentos, atitudes e práticas de agricultores familiares brasileiros sobre a exposição aos agrotóxicos

Cited by 2 publications

References 21 publications

Somatic DNA Damage Response and Homologous Repair Gene Alterations and Its Association With Tumor Variant Burden in Breast Cancer Patients With Occupational Exposure to Pesticides

Somatic DNA Damage Response and Homologous Repair Gene Alterations and Its Association With Tumor Variant Burden in Breast Cancer Patients With Occupational Exposure to Pesticides

O Conto da maçã envenenada: Trabalhadores brasileiros morrem diariamente por exposição intensa a agrotóxicos / The Tale of the Poisoned Apple: Brazilian Workers die daily from intense exposure to pesticides

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