Spray-drying technique to prepare innovative nanoparticulated formulations for drug administration: a brief overview

Guterres, Sı́lvia Stanisçuaski; Beck, Ruy Carlos Ruver; Pohlmann, Adriana Raffin

doi:10.1590/s0103-97332009000200013

Cited by 43 publications

(18 citation statements)

References 27 publications

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“…In some cases, these aqueous suspensions present limited physicochemical stability under storage due to the possibility of particle aggregation [ 26 ], the degradation of components such as the polymer [ 27 - 29 ] or drug leakage [ 29 - 31 ]. Freeze-drying [ 23 , 29 ] and spray-drying techniques [ 32 , 33 ] have been reported as alternatives to improve the stability of nanoparticle suspensions by means of their conversion into powders. Spray-dried powders containing melatonin-loaded Eudragit® S100 nanocapsules were prepared using silicon dioxide as drying adjuvants, showing a controlled drug release profile in comparison with the pure drug [ 34 ].…”

Section: Introductionmentioning

confidence: 99%

Hydrogels containing redispersible spray-dried melatonin-loaded nanocapsules: a formulation for transdermal-controlled delivery

et al. 2012

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The aim of the present study was to develop a transdermal system for controlled delivery of melatonin combining three strategies: nanoencapsulation of melatonin, drying of melatonin-loaded nanocapsules, and incorporation of nanocapsules in a hydrophilic gel. Nanocapsules were prepared by interfacial deposition of the polymer and were spray-dried using water-soluble excipients. In vitro drug release profiles were evaluated by the dialysis bag method, and skin permeation studies were carried out using Franz cells with porcine skin as the membrane. The use of 10% (w/v) water-soluble excipients (lactose or maltodextrin) as spray-drying adjuvants furnished redispersible powders (redispersibility index approximately 1.0) suitable for incorporation into hydrogels. All formulations showed a better controlled in vitro release of melatonin compared with the melatonin solution. The best controlled release results were achieved with hydrogels prepared with dried nanocapsules (hydrogels > redispersed dried nanocapsules > nanocapsule suspension > melatonin solution). The skin permeation studies demonstrated a significant modulation of the transdermal melatonin permeation for hydrogels prepared with redispersible nanocapsules. In this way, the additive effect of the different approaches used in this study (nanoencapsulation, spray-drying, and preparation of semisolid dosage forms) allows not only the control of melatonin release, but also transdermal permeation.

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Section: Introductionmentioning

confidence: 99%

Hydrogels containing redispersible spray-dried melatonin-loaded nanocapsules: a formulation for transdermal-controlled delivery

et al. 2012

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“… 28 The spray-drying technique is usually used as an alternative to improve the stability of nanosuspensions by means of their conversion into dried nanocrystal powders. 29 The BRE-NS were spray-dried with a Buchi mini spray-dryer (model B290, Buchi Labortechnik AG, Flawil, Switzerland). Mannitol was added to BRE-NS to facilitate spray-drying.…”

Section: Methodsmentioning

confidence: 99%

Nose-to-Brain Delivery by Nanosuspensions-Based in situ Gel for Breviscapine

Chen

Liu

Xie

et al. 2020

IJN

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Purpose Nose-to-brain drug delivery is an effective approach for poorly soluble drugs to bypass the blood–brain barrier. A new drug intranasal delivery system, a nanosuspension-based in situ gel, was developed and evaluated to improve the solubility and bioavailability of the drug and to prolong its retention time in the nasal cavity. Materials and Methods Breviscapine (BRE) was chosen as the model drug. BRE nanosuspensions (BRE-NS) were converted into BRE nanosuspension powders (BRE-NP). A BRE nanosuspension in situ gelling system (BRE-NG) was prepared by mixing BRE-NP and 0.5% gellan gum (m/v). First, the BRE-NP were evaluated in terms of particle size and by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Subsequently, the critical ionic concentration of the gellan gum phase transition, influence of the deacetylated gellan gum (DGG) concentration on the expansion coefficient (S%), water-holding capacity, rheological properties and in vitro release behaviour of the BRE-NG were investigated. The pharmacokinetics and brain distribution of the BRE-NG after intranasal administration were compared with those of the intravenously injected BRE-NP nanosuspensions in rats. Results The rheology results demonstrated that BRE-NG was a non-Newtonian fluid with good spreadability and bioadhesion performance. Moreover, the absolute bioavailability estimated for BRE-NG after intranasal administration was 57.12%. The drug targeting efficiency (DTE%) of BRE in the cerebrum, cerebellum and olfactory bulb was 4006, 999 and 3290, respectively. The nose-to-brain direct transport percentage (DTP%) of the cerebrum, cerebellum and olfactory bulb was 0.975, 0.950 and 0.970, respectively. Conclusion It was concluded that the in situ gel significantly increased the drug retention time at the administration site. Therefore, the nanosuspension-based in situ gel could be a convenient and effective intranasal formulation for the administration of BRE.

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“…Spray-drying technique has been applied to prepare innovative nanoparticulate formulations for drug administration and other types of nanosystems [26]. However, applications of polymeric nanoparticles tend to agglomerate due to the reduced stability of formulations when conserved in aqueous medium for a long period.…”

Section: Spray Dryingmentioning

confidence: 99%

Nanotechnology: Development and challenges in Indonesia

Joni

Muthukannan

Hermawan

et al. 2018

AIP Conference Proceedings

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Abstract. Nanotechnology today is regarded as a revolutionary technology that can help to address the key needs related to energy, environment, health and agriculture in developing countries. This paper is a short review on the development and challenges of nanotechnology in Indonesia. Nanotechnology offers great potential benefits, there is emerging concerns arising from its novel physicochemical properties. The main applications of nanotechnology in the different sectors which is vital and its economic impact in Indonesia is also discussed. The achievment and development of nanotechnology including synthesis and dispersion of nanoparticles (NPs) and its applications in various fields is briefly addressed in Nanotehcnology and Graphene Research Center, Universitas Padjadjaran (Unpad). Despite significant progress in developmental goals, many challenges in the development of nanotechnology proccesing need to be resolved such as support infrastructure and evolution of new form of collaborative arrangements between various sectors and policies which is emerged as an important factor enabling development.

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Spray-drying technique to prepare innovative nanoparticulated formulations for drug administration: a brief overview

Cited by 43 publications

References 27 publications

Hydrogels containing redispersible spray-dried melatonin-loaded nanocapsules: a formulation for transdermal-controlled delivery

Hydrogels containing redispersible spray-dried melatonin-loaded nanocapsules: a formulation for transdermal-controlled delivery

Nose-to-Brain Delivery by Nanosuspensions-Based in situ Gel for Breviscapine

Nanotechnology: Development and challenges in Indonesia

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