In this contribution, pursuing our research program extending the atoms in molecules analysis into unorthodox domains, another key ingredient of the two-component quantum theory of atoms in molecules (TC-QTAIM) namely, the theory of localization/delocalization of quantum particles, is disclosed. The unified proposed scheme is able not only to deal with the localization/delocalization of electrons in/between atomic basins, but also to treat nuclei as well as exotic particles like positrons and muons equally. Based on the general reduced second order density matrices for indistinguishable quantum particles, the quantum fluctuations of atomic basins are introduced and then used as a gauge to quantify the localization/delocalization introducing proper indexes. The explicit mass-dependence of the proposed indexes is demonstrated and it is shown that a single localization/delocalization index is capable of being used for all kind of quantum particles regardless of their masses or charge content. For various non-Born-Oppenhiemer (non-BO) wavefunctions, including Hartree-product as well as singlet and triplet determinants, the indices are calculated and then employed to rationalize the localization/delocalization of particles in a series of fourbody model systems consist of two electrons and two positively charged particles with variable mass. The ab initio FV-MC_MO derived non-BO wavefunctions for the four-body series are used for a comprehensive computational TC-QTAIM analysis, including topological analysis as well as basin integrations, in a wide mass regime, (m e stands for electron mass), disclosing various traits in these series of species that are unique to the TC-QTAIM. On the other hand, it is demonstrated that in the large mass extreme the TC-QTAIM analysis reduces to the one performed within context of the orthodox QTAIM with two clamped positive particles revealing the fact that the TC-QTAIM encompasses the orthodox QTAIM as an asymptote. Finally, it is concluded that the proposed localization/delocalization scheme is capable of quantifying quantum tunneling of nuclei for systems containing delocalized protons. Such capability promises novel applications for the TC-QTAIM as well as its extended multi-component version (MC-QTAIM) introduced recently.