Bilayer membranes with 2D-nematic order of the surfactant polar heads

Fournier, Jean‐Baptiste; Galatola, P.

doi:10.1590/s0103-97331998000400008

Cited by 28 publications

(25 citation statements)

References 3 publications

(4 reference statements)

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“…It was shown that at sublytic concentrations of amphiphiles in the RBC suspension, the anisotropic amphiphiles induce tubular membrane budding and the release of stable tubular microexovesicles [18,35,37,49,51], while most of the other amphiphile molecules induce small, predominantly spheroidal microexovesicles that are formed from small membrane buds [8,35,51,52]. The experimentally observed tubular budding and vesiculation of the RBC membrane [18,35,49,51] can be theoretically explained by deviatoric membrane properties due to the in-plane orientational ordering of anisotropic membrane inclusions [8,10,15,[53][54][55][56][57][58][59][60][61].…”

Section: Membrane Budding and Endovesiculationmentioning

confidence: 99%

“…The orientational order in membranes could occur due to the anisotropic shape of membrane components like anisotropic proteins or lipids [8,53,56,[78][79][80]. A typical example of inclusions possessing nematic order [58] are anisotropic banana shaped BAR protein domains [11,81,82]. The orientational order often arises in highly curved parts of the membrane due to the alignment of these anisotropic components [8,51,76].…”

Section: Fission Of the Membrane Daughter Endovesiclesmentioning

confidence: 99%

“…Furthermore, chiral membrane constituents [83,84] or selforganized filament networks [85] may also be a source of the membrane orientational order. The orientational order in membranes has been observed in giant unilamellar vesicles where lipid molecules were in the gel or in some other ordered phase [58,76,86]. In-plane ordering in biological membranes may occur also due to the tilt of lipid tails relative to the surface normal [83,87,88].…”

Section: Fission Of the Membrane Daughter Endovesiclesmentioning

confidence: 99%

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Budding and Fission of Membrane Vesicles: A Mini Review

et al. 2020

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In this mini-review, a brief historical survey of the mechanisms which determine the shapes of liposomes and cells and the budding and fission of their membrane is presented. Special attention is given to the role of orientational ordering of membrane components in thin membrane necks which connect the membrane buds (daughter vesicles) to the parent membrane. It is indicated that topological anti-defects in membrane necks may induce the rupture of the neck and the fission of the membrane daughter vesicles.

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Section: Membrane Budding and Endovesiculationmentioning

confidence: 99%

Section: Fission Of the Membrane Daughter Endovesiclesmentioning

confidence: 99%

Section: Fission Of the Membrane Daughter Endovesiclesmentioning

confidence: 99%

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Budding and Fission of Membrane Vesicles: A Mini Review

et al. 2020

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“…We will show in the remainder of this section (and also in section 5) that a source for anisotropic bending energy will be the minimal requirement to explain the emergence and stability of tubular shapes, which could arise from an in-plane orientational field on the membrane [298, 299]. In general, the different types of intrinsic and extrinsic in-plane order, discussed in section 4.1, can be represented as a p -atic in-plane field.…”

Section: Modeling Membrane Proteins As Spontaneous Curvature Fieldsmentioning

confidence: 99%

Mesoscale computational studies of membrane bilayer remodeling by curvature-inducing proteins

2014

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Biological membranes constitute boundaries of cells and cell organelles. These membranes are soft fluid interfaces whose thermodynamic states are dictated by bending moduli, induced curvature fields, and thermal fluctuations. Recently, there has been a flood of experimental evidence highlighting active roles for these structures in many cellular processes ranging from trafficking of cargo to cell motility. It is believed that the local membrane curvature, which is continuously altered due to its interactions with myriad proteins and other macromolecules attached to its surface, holds the key to the emergent functionality in these cellular processes. Mechanisms at the atomic scale are dictated by protein-lipid interaction strength, lipid composition, lipid distribution in the vicinity of the protein, shape and amino acid composition of the protein, and its amino acid contents. The specificity of molecular interactions together with the cooperativity of multiple proteins induce and stabilize complex membrane shapes at the mesoscale. These shapes span a wide spectrum ranging from the spherical plasma membrane to the complex cisternae of the Golgi apparatus. Mapping the relation between the protein-induced deformations at the molecular scale and the resulting mesoscale morphologies is key to bridging cellular experiments across the various length scales. In this review, we focus on the theoretical and computational methods used to understand the phenomenology underlying protein-driven membrane remodeling. Interactions at the molecular scale can be computationally probed by all atom and coarse grained molecular dynamics (MD, CGMD), as well as dissipative particle dynamics (DPD) simulations, which we only describe in passing. We choose to focus on several continuum approaches extending the Canham - Helfrich elastic energy model for membranes to include the effect of curvature-inducing proteins and explore the conformational phase space of such systems. In this description, the protein is expressed in the form of a spontaneous curvature field. The approaches include field theoretical methods limited to the small deformation regime, triangulated surfaces and particle-based computational models to investigate the large-deformation regimes observed in the natural state of many biological membranes. Applications of these methods to understand the properties of biological membranes in homogeneous and inhomogeneous environments of proteins, whose underlying curvature fields are either isotropic or anisotropic, are discussed. The diversity in the curvature fields elicits a rich variety of morphological states, including tubes, discs, branched tubes, and caveola. Mapping the thermodynamic stability of these states as a function of tuning parameters such as concentration and strength of curvature induction of the proteins is discussed. The relative stabilities of these self-organized shapes are examined through free-energy calculations. The suite of methods discussed here can be tailored to applications in specific cellular set...

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“…[10][11][12] The protein distribution and their cooperative effect on membrane morphology has been theoretically investigated by extending the existing membrane models. [13][14][15][16] However, the realm of these theoretical models are restricted to axisymmetric membrane shapes and small deviations around it.…”

Section: Introductionmentioning

confidence: 99%

Modeling Anisotropic Elasticity of Fluid Membranes

Ramakrishnan¹,

Kumar²,

Ipsen³

2011

Macro Theory & Simulations

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The biological membrane, which compartmentalizes the cell and its organelles, exhibit wide variety of macroscopic shapes of varying morphology and topology.s A systematic understanding of the relation of membrane shapes to composition, external field, environmental conditions etc. have important biological relevance. Here we review the triangulated surface model, used in the macroscopic simulation of membranes and the associated Monte Carlo (DTMC) methods. New techniques to calculate surface quantifiers, that will facilitate the study of additional in-plane orientational degrees of freedom, has been introduced. The mere presence of a polar and nematic fields in the ordered phase drives the ground state conformations of the membrane to a cylinder and tetrahedron respectively.

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Bilayer membranes with 2D-nematic order of the surfactant polar heads

Cited by 28 publications

References 3 publications

Budding and Fission of Membrane Vesicles: A Mini Review

Budding and Fission of Membrane Vesicles: A Mini Review

Mesoscale computational studies of membrane bilayer remodeling by curvature-inducing proteins

Modeling Anisotropic Elasticity of Fluid Membranes

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