Aplicação materna de glicocorticoide nos parâmetros vitais de cordeiros nascidos a termo e prematuros

Ávila, Larissa Gabriela; Bovino, Fernanda; Camargo, Diogo Gaubeur de; Souza, Natália Cristina de; Santos, Guilherme Gonçalves Fabretti; Deschk, Maurício; Mendes, Luiz Cláudio Nogueira; Feitosa, Francisco Leydson Formiga

doi:10.1590/s0103-84782014000600025

Cited by 6 publications

(6 citation statements)

References 18 publications

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“…O parto representa estresse considerável para o feto, uma vez que as contrações uterinas afetam o fluxo sanguí-neo placentário, causando hipóxia e hipercapnia (Ávila et al 2014(Ávila et al , Lisbôa et al 2002. Esta condição é agravada pela reduzida capacidade pulmonar (hipoventilação) que não garante a remoção do CO 2 na mesma proporção em que é produzido, causando diminuição da concentração hidrogeniônica do sangue (Ortolani 2003, Piccione et al 2006.…”

Section: Resultsunclassified

Efeitos da corticoterapia materna nos valores hemogasométricos de cordeiros nascidos a termo e prematuros

Feitosa

Ávila

Bovino³

et al. 2017

Pesq. Vet. Bras.

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RESUMO: O objetivo do estudo foi avaliar as variáveis hemogasométricas de cordeiros nascidos a termo e prematuros do nascimento às 48 horas de vida. Foram constituídos quatros grupos experimentais: PN (cordeiros nascidos de parto normal, n=15, média de 146 dias de gestação); PNDEX (cordeiros nascidos de parto normal, cujas mães receberam 16 mg de dexametasona aos 141 de gestação, n=8, média de 143 dias de gestação); PRE (cordeiros prematuros nascidos de cesarianas aos 138 dias de gestação, n=10) e PREDEX (cordeiros prematuros nascidos de cesarianas aos 138 dias de gestação, cujas mães receberam 16 mg de dexametasona dois dias antes do parto, n=9). Imediatamente após o nascimento, os cordeiros de todos os grupos apresentaram quadro de acidose respiratória (pH baixo e pCO2 elevada), com maior ênfase nos animais prematuros. A concentração de HCO3 - diminuiu entre 15 e 60 minutos de vida, principalmente nos grupos PRE e PREDEX, com posterior aumento no M24h. Os valores de diferença de base foram menores nos cordeiros prematuros, os quais apresentaram respiração abdominal, intensa dispneia e grande quantidade de líquido pulmonar. A estabilização do equilíbrio ácidobase ocorreu em todos os animais ao longo das primeiras 24 horas de vida. A dexametasona teve influência positiva sobre a condição clínica dos animais prematuros, resultando em adequada ventilação e perfusão tecidual, o que garantiu maior taxa de sobrevivência.

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Section: Resultsunclassified

Efeitos da corticoterapia materna nos valores hemogasométricos de cordeiros nascidos a termo e prematuros

Feitosa

Ávila

Bovino³

et al. 2017

Pesq. Vet. Bras.

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“…A score between 7 and 8 represented good vitality, 4 to 6 was considered moderate vitality, and 0 to 3 was considered low vitality (depressed). Apgar evaluation has been widely used as a routine method in newborn lambs and goats (Feitosa et al 2020, Avila et al 2014. Lambs belonging to Groups II and III were closely monitored and bottle-fed (50ml) where possible with colostrum harvested from their mothers.…”

Section: Methodsmentioning

confidence: 99%

“…In other words, lambs born just 7 days before the expected date of delivery are at great risk of dying, even before the first 24 hours of life. Therefore, according the some studies, lambs born with an average of 138 days can be considered premature (Radostits et al 2007, Avila et al 2014, Bovino 2015, Feitosa et al 2017, Miura et al 2019.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of fetal lung maturity using analysis of amniotic fluid from ewes that gave birth prematurely and at term

Souza

Bovino²,

Avilla

et al. 2020

Pesq. Vet. Bras.

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The aim of this study was to evaluate the lung maturity of premature and full-term lambs by analyzing amniotic fluid using the following methods: Clements test, Nile blue cytology test, hematoxylin-Shorr stain, lamellar body count, and radiographic tests. The use of these methods is intended to identify high-risk newborns and provide immediate clinical intervention after birth. Altogether, 56 animals (24 ewes and 32 lambs) were included in the study and divided into 3 groups. Group I consisted of 8 ewes that were at approximately 145 days of gestation; this group delivered 10 lambs naturally. Group II consisted of 8 ewes that were at 138 days’ gestation; this group delivered 11 lambs by cesarean section. Group III consisted of 8 ewes at 138 days’ gestation; this group was administered intramuscular dexamethasone (16mg/animal) 36 hours prior to a cesarean section. Group III delivered11 lambs. Cytological tests were performed using a microscope with a maximum magnification of 1000x, while the Clements test was visually observed by one of the researchers. Amnioticfluid lamellar body counts were measured using transmission electron microscopy. Among the staining methods, hematoxylin-Shorr was reliable, and Group III had a greater number of orangeophilic cells when compared to Group II, probably due to corticoid administration. The Clements test showed pulmonary maturity in approximately 20% of Group I lambs and Group II showed 9.1% of bubbles; however, Group III had the highest pulmonary maturity percentage (36.4%). The lamellar bodies were measured, and all groups had sizes between 0.019 and 0.590μm. Radiographic evaluation revealed that the majority of lambs presented some level of pulmonary radiodensity, indicating an acinar pattern at birth. These results are in line with the expectations of each group. We found that the normal group showed greater pulmonary maturity, whereas Group II presented pulmonary immaturity, which is expected because this group comprised lambs born prematurely and Group III showed pulmonary maturity almost comparable to the normal delivery group (Group I). This is due to the fact that although these animals are premature, the use of dexamethasone helped in pulmonary maturation. Therefore, these pulmonary maturity tests are considered effective when more than one technique is used and can be used routinely in the care of a pregnant ewe in labor, where a simple collection of amniotic fluid can predict a high-risk pregnancy and alert the veterinarian if the newborn needs intensive supportive treatment.

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“…Blood glucose, as well as oxygen, is essential for metabolism, being one of the primary energetic substrates for the life process of mammalian cells (Kaneko et al, 2008). Its level is regulated by the release of glycogen deposits, their capture, and peripheral use (Avila, 2013).…”

Section: Variablementioning

confidence: 99%

Correlation between pre and post-slaughter physiological parameters in lambs

Fonseca

Mendonça

Robaldo

et al. 2020

RSD

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The objective of this study was to obtain information with scientific validity regarding the probable physiological alterations that sheep may suffer in the period prior to slaughter and its relationship with welfare conditions and maintenance of homeostasis. Twenty-nine castrated male lambs were used, clinically healthy, with no defined breed, and aged up to one year. Before slaughter, the heart and respiratory frequencies were measured, as well as the rectal temperature. At the time of bleeding, a blood sample was collected for analysis of hematological parameters (lactic acid, glucose, hematocrit). The mean value found for the rectal temperature was 39.30 ± 0.45 °C, for respiratory rate of 64.10 ± 28.52mov/min, heart rate of 106.90 ± 30.57bat/min, lactic acid of 4.81 ± 1.04mmol/L, glucose of 69.79 ± 10.33mg/dL and hematocrit of 38.93 ± 3.28%. The database analysis showed a low and positive correlation between respiratory rate and rectal temperature. It was concluded that lambs kept at high temperatures showed an increase in respiratory and cardiac frequencies, as well as an intensification of the stress condition reflected by the increase in plasma lactic acid levels.

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Aplicação materna de glicocorticoide nos parâmetros vitais de cordeiros nascidos a termo e prematuros

Abstract: RESUMO O objetivo deste trabalho foi avaliar a infl uência do glicocorticoide sobre parâmetros vitais de cordeiros nascidos a termo e prematuros, do nascimento às 48 horas de vida. Foram constituídos quatros grupos: PN (cordeiros nascidos de

Cited by 6 publications

References 18 publications

Efeitos da corticoterapia materna nos valores hemogasométricos de cordeiros nascidos a termo e prematuros

Efeitos da corticoterapia materna nos valores hemogasométricos de cordeiros nascidos a termo e prematuros

Assessment of fetal lung maturity using analysis of amniotic fluid from ewes that gave birth prematurely and at term

Correlation between pre and post-slaughter physiological parameters in lambs

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