Ivermectina e abamectina em diferentes doses e vias de aplicação contra larvas de Cochliomyia hominivorax em bolsas escrotais de bovinos recém-castrados, provenientes da região sudeste do Brasil

Lopes, Welber Daniel Zanetti; Teixeira, Weslen Fabrício Pires; Felippelli, Gustavo; Cruz, Breno Cayeiro; Maciel, W. J.; Matos, Lucas Vinícius Shigaki de; Pereira, João Carlos Melo; Soares, Vando Edésio; Santos, Thaís Rabelo dos; Oliveira, Gilson Pereira de; Costa, Alvimar José da

doi:10.1590/s0103-84782013001200013

Cited by 12 publications

(10 citation statements)

References 9 publications

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“…On the other hand, against C. hominivorax larvae, all pour‐on formulations tested (1.5 per cent ivermectin +0.5 per cent abamectin, 0.5 per cent ivermectin and 0.5 per cent abamectin), as well as 1 per cent doramectin administered subcutaneously, were considered ineffective, in two different experiments, when administered preventively against larvae of this ectoparasite. Similar results, with ivermectin and abamectin (administered through pour‐on or injectable routes), were obtained by Lopes and others (2013a, b, c). Published works that describe pharmacokinetic aspects of formulations (pour‐on and/or injectable) can elucidate the possible ineffectiveness on these cases.…”

Section: Discussionsupporting

confidence: 84%

“…microplus revealed that the pour-on combination of 1.5 per cent ivermectin +0.5 per cent abamectin showed better efficacy indexes against this ectoparasite when compared with formulations containing 0.5 per cent ivermectin, 1 per cent ivermectin and the 1 per cent abamectin+20 per cent levamisole. Using the same tick strain, Lopes and others (2013a , b , c ) diagnosed R. (B.)…”

Section: Discussionmentioning

confidence: 98%

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Endectocide activity of a pour‐on formulation containing 1.5 per cent ivermectin +0.5 per cent abamectin in cattle

Silva¹,

Prette

Lopes

et al. 2015

Veterinary Record Open

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The present work aimed to evaluate, through ten different studies, the therapeutic efficacy of a new pour-on formulation, containing 1.5 per cent ivermectin +0.5 per cent abamectin, against parasites of cattle. Results obtained on trials against Rhipicephalus (Boophilus) microplus showed that the pour-on combination of 1.5 per cent ivermectin +0.5 per cent abamectin obtained superior efficacy indexes against this ectoparasite, when compared with formulations containing 0.5 per cent ivermectin, 1 per cent ivermectin and the combination of 1 per cent abamectin +20 per cent levamisole. The results of efficacy of the ivermectin+abamectin and the 0.5 per cent ivermectin against Haematobia irritans were similar. Against Cochliomyia hominivorax larvae, all pour-on formulations tested (1.5 per cent ivermectin +0.5 per cent abamectin, 0.5 per cent ivermectin and 0.5 per cent abamectin), as well as 1 per cent doramectin administered subcutaneously, were considered ineffective. Cattle medicated with 1.5 per cent ivermectin +0.5 per cent abamectin, pour-on, remained free from parasitism by Dermatobia hominis larvae during 42 days (96 per cent efficacy), while values superior to 90 per cent were obtained by 0.5 per cent ivermectin (92 per cent) and 0.5 per cent abamectin (93 per cent) until the 42nd and 35th days post treatment, respectively. Against Haemonchus placei and Oesophagostomum radiatum, the pour-on of ivermectin+abamectin showed better efficacy than the 0.5 per cent ivermectin and 0.5 per cent abamectin. As to Cooperia punctata, there was no difference regarding efficacy results obtained by the avermectins combination and abamectin. The pour-on combination of 1.5 per cent ivermectin +0.5 per cent abamectin obtained high efficacy against R. (B.) microplus, D. hominis and some species of cattle gastrointestinal helminths when compared with formulations of 0.5 per cent ivermectin and 0.5 per cent abamectin administered through the same route.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 98%

Endectocide activity of a pour‐on formulation containing 1.5 per cent ivermectin +0.5 per cent abamectin in cattle

Silva¹,

Prette

Lopes

et al. 2015

Veterinary Record Open

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“…The main form of treatment and control of myiasis by C. hominivorax in zootechnical animals consists of massive use of chemosynthetic insecticides, either topically or systemically [17]. Currently, there are several scientific reports on the loss of therapeutic and prophylactic efficacy of chemosynthetic insecticides to control myiasis in domestic animals [17] [20]. The indiscriminate use of these products causes high economic expenses for producers, besides offering risks to managers' and consumers' health [21].…”

Section: Impact On Animal and On Environmental Healthmentioning

confidence: 99%

Myiasis by <i>Cochliomyia hominivorax</i> (Coquerel, 1858): A Neglected Zoonosis in Brazil

Barros¹,

Bricarello²

2020

OJVM

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Myiasis is the lesion resulting from the parasitism of diptera larval form in the living tissues of vertebrate animals. These are bloody conditions, causing severe damage to the welfare and the health of humans and animals. In Brazil, Cochliomyia hominivorax is the main responsible species for causing myiasis in humans and animals. The conventional treatment of these lesions in animals massively uses chemosynthetic products. The irrational use of these molecules has led to environmental degradation and has affected human health. The standard treatment of human myiasis is based only on larvae removal, surgically or not, supported by the use of antiparasitic drugs. Human myiasis is an important zoonosis, given its close relation with animal myiasis. However, this zoonosis has currently been neglected in Brazil and other developing countries in America. The One Health approach makes it possible to realize that the occurrence of myiasis in humans is directly related to the maintenance of stocks of this diptera in nature. Recognizing the direct relation that domestic and wild animals have as reservoirs in the human myiasis cycle is essential, in order to formulate strategies to control this ancient and important disease that still affects the population in Brazil.

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“…Topical and systemic antiparasitic agents are used to control C. hominivorax larvae in bovines (Lopes et al ., 2013). Approximately 160 products are currently registered in Brazil for the control of this parasite (SINDAN, 2018).…”

Section: Introductionmentioning

confidence: 99%

In vitro test for the evaluation of the efficacy of topical products for the control of Cochliomyia hominivorax larvae

Nogueira¹,

Silva²,

Furtado³

et al. 2020

Parasitology

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Cochliomyia hominivorax larvae cause myiasis in animals and humans. To register a commercial product to control this dipteran is necessary to experiment on animals. The in vitro test was standardized to evaluate the larvicidal efficacy of commercial topical products. Five formulations were analysed in vitro and in vivo. For the in vitro test, a colony was formed and three replicates (n = 200) of each larval stage (L1, L2 and L3) were treated. The viability of the larvae was evaluated after 5 and 30 min, and at 1, 2, 6, 12, 24, 48, 60 and 72 h post-treatment (HPT). For the in vivo test, 30 bovines divided into six groups were castrated to achieve natural infestation with C. hominivorax. Animals in the treated groups received the product. Myiasis and efficacy were evaluated 12, 24, 36, 48, 60 and 72 HPT. Four formulations tested in the in vitro test achieved 100% efficacy at 24 HPT. In the in vivo experiment only one achieved 100% efficacy at 24 HPT. However, all products achieved the maximum efficacy by the end of study. The in vitro test developed here could be adopted to evaluate the efficacy of topical products for the control of C. hominivorax larvae.

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Ivermectina e abamectina em diferentes doses e vias de aplicação contra larvas de Cochliomyia hominivorax em bolsas escrotais de bovinos recém-castrados, provenientes da região sudeste do Brasil

Abstract: RESUMO Avaliou-se a efi cácia preventiva da ivermectina e da abamectina, administradas em diferentes vias (subcutânea, intramuscular e pour-on) e doses (200 e 500mcg kg

Cited by 12 publications

References 9 publications

Endectocide activity of a pour‐on formulation containing 1.5 per cent ivermectin +0.5 per cent abamectin in cattle

Endectocide activity of a pour‐on formulation containing 1.5 per cent ivermectin +0.5 per cent abamectin in cattle

Myiasis by <i>Cochliomyia hominivorax</i> (Coquerel, 1858): A Neglected Zoonosis in Brazil

In vitro test for the evaluation of the efficacy of topical products for the control of Cochliomyia hominivorax larvae

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Ivermectina e abamectina em diferentes doses e vias de aplicação contra larvas de Cochliomyia hominivorax em bolsas escrotais de bovinos recém-castrados, provenientes da região sudeste do Brasil

Abstract: RESUMO Avaliou-se a efi cácia preventiva da ivermectina e da abamectina, administradas em diferentes vias (subcutânea, intramuscular e pour-on) e doses (200 e 500mcg kg

Cited by 12 publications

References 9 publications

Endectocide activity of a pour‐on formulation containing 1.5 per cent ivermectin +0.5 per cent abamectin in cattle

Endectocide activity of a pour‐on formulation containing 1.5 per cent ivermectin +0.5 per cent abamectin in cattle

Myiasis by &lt;i&gt;Cochliomyia hominivorax&lt;/i&gt; (Coquerel, 1858): A Neglected Zoonosis in Brazil

In vitro test for the evaluation of the efficacy of topical products for the control of Cochliomyia hominivorax larvae

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Myiasis by <i>Cochliomyia hominivorax</i> (Coquerel, 1858): A Neglected Zoonosis in Brazil