Sobre a analgesia pós-operatória da morfina, cetamina ou da associação em cadelas submetidas à ovariossalpingohisterectomia eletiva

Almeida, Maria Raquel de; Luna, Stélio Pacca Loureiro; Alves, Robson Moreira; Hashimoto, Hetielle Harumi; Almeida, Ricardo Miyasaka de

doi:10.1590/s0103-84782013000700020

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…In this study, the DIVAS scores in the group treated with amantadine were significantly lower than those in the control group. This result is consistent with those of previous studies in which other NMDA receptor antagonists reduced postoperative pain from thoracotomy in humans (Moyse et al, 2017) and demonstrated antinociceptive effect in rats (Wolinska et al, 2017;Doncheva et al, 2019) and in dogs undergoing ovariohysterectomy (Slingsby and Waterman-Pearson, 2010;Almeida et al, 2013;Shah et al, 2018).…”

Section: Discussionsupporting

confidence: 92%

Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs

Niella

Sena

Corrêa

et al. 2020

RSD

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This study aimed to evaluate the preemptive analgesic effect of amantadine on postoperative pain control in female dogs that underwent ovariohysterectomy. Twenty female dog were randomly assigned to two groups of ten. The control group (CONTROL) received oral placebo capsules, while the amantadine (AMANT) group received 5 mg/kg of oral amantadine one hour before sedation. All the animals were premedicated with 3 mg/kg (IM) meperidine, induced with propofol and maintained with isofluorane. The transanesthetic physiological parameters were recorded, and postoperative pain was evaluated every hour after extubation for six hours with the Dynamic Interactive Visual Analog Scale (DIVAS) and mechanical nociceptive threshold (MNT) and when the necessary analgesic rescue was administered (morphine, 0.2 mg/kg (IM)). During the surgical procedure, there was no significant difference in the variables measured between the two groups. Regarding postoperative pain assessment, there was a significant difference in the DIVAS score (p = 0.004) between the groups, in which AMANT required fewer rescues than did CONTROL (p = 0.03). The MNT was significantly higher in AMANT than in CONTROL (p = 0.03). The results suggested that the preoperative administration of amantadine decreased analgesic requirement in female dogs that underwent elective ovariohysterectomy.

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Section: Discussionsupporting

confidence: 92%

Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs

Niella

Sena

Corrêa

et al. 2020

RSD

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“…The times used for the assessments through the scales are described in the literature (10,16,22) and were used to measure pain in bitches submitted for OH. Changes in animal behavior in response to pain can be difficult to interpret after surgery; for this reason, more than one evaluator and scoring system were considered for adequate pain assessment, corroborating other authors (19,23) .…”

Section: Discussionmentioning

confidence: 99%

Postoperative evaluation of analgesia promoted by the use of dexmedetomidine alone and associated with morphine as an intramuscular pre-anesthetic medication in bitches submitted for ovariohysterectomy

et al. 2021

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This study aimed to evaluate the postoperative analgesic efficacy of dexmedetomidine alone and when associated with morphine in patients under general inhalational anesthesia with isoflurane and undergoing elective ovariohysterectomy (OH). Twenty healthy bitches were selected via physical and laboratory examinations. Prior to the study, they underwent a 24-h period of adaptation to the environment and observers. They were then randomly divided into two groups: the dexmedetomidine group receiving a dose of 10 μg/kg, and dexmedetomidine group (10 μg/kg) associated with morphine receiving a dose of 0.3 mg/kg, administered via the intramuscular route. Thereafter, patients were induced with propofol and maintained with isoflurane diluted in 100% oxygen administered through a calibrated vaporizer. To verify postoperative analgesia, pain assessments were performed using the modified Glasgow (EGM) and Melbourne (EM) scales. For sedation assessment, the Dobbins scale was used at different times: before the administration of pre-anesthetic medication (T0) and at another six times in the postoperative period, 1 (T1), 2 (T2), 4 (T3), 8 (T4), 12 (T5), and 24 (T6) h after orotracheal extubation. No statistical differences were observed between groups in the scales according to Dunn’s Kruskal-Wallis post hoc test, and between the times a statistical difference was noticed by the Friedman test (p<0.05) for the EGM and EM scale scores, but there was no need for analgesic rescue. Therefore, we found that isolated dexmedetomidine and morphine produced adequate analgesic effects in the postoperative period of bitches submitted for OH.

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“…As alterações do comportamento animal na presença de dor são variáveis dentre os indivíduos e isso pode dificultar a sua identificação no período pós-operatório, por esse motivo recomenda-se a utilização de mais de um método de avaliação [2] e foram empregadas duas escalas de dor. Os momentos de avaliação foram estabelecidos com base no estudo de Almeida et al [1], que utilizou a mesma EGM, espécie animal e procedimento cirúrgico. A EGM é uma escala útil para mensuração da dor perioperatória, de fácil e rápida utilização, além de permitir a avaliação de comportamentos que podem estar associado à dor [13], o que permite uma observação mais detalhada e fiel do comportamento do animal e por isso foi utilizada como referência para a realização dos resgates analgésicos.…”

Section: Discussionunclassified

Evaluation of Postoperative Analgesia of DexmedetomidineAlone or Associated to Morphineas Premedicants in Bitches Undergoing Ovariosalpingohisterectomy

Costa

Mascarenhas

Filho

et al. 2019

Acta Scientiae. Vet.

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Avaliação da analgesia pós-operatória da dexmedetomidina isolada e associada à morfina quando utilizada na medicação pré-anestésica em cadelas submetidas à ovariosalpingohisterectomia eletivaABSTRACT Background: Elective ovariossalpingohysterectomy is a common surgery that causes mild to moderate pain. Aiming at the treatment of pain in these patients, analgesia should be balanced from pre-anesthetic, transoperative and postoperative medication, with -2-agonists and opioids being commonly used, especially dexmedetomidine that has sedation, relaxation muscle and analgesia.The aim of the present study was to evaluate the postoperative analgesic efficacy of dexmedetomidine alone and associated with morphine when used in the preanesthetic medication of bitches submitted to elective ovarian oysterectomy using the modified Glasgow pain scale and the Melbourne pain scale. Materials, Methods & Results:Twenty bitches were used in this study, all of them submitted to ovarian oysterectomy, and were clinically healthy according to laboratory and clinical exams. During the experiment, bitches were randomly distributed into two groups, which received preanesthetic medication (MPA) with 5 μg/kg dexmedetomidine alone (GD) or associated with 0.3 mg/kg morphine (GDM) intramuscularly (IM). In both groups, anesthetic induction with dose-effect propofol was performed and maintained with isoflurane diluted in 100% oxygen administered through a calibrated vaporizer and appropriate anesthetic system based on the weight of the animal and maintained on spontaneous ventilation. After stabilization of the patient the surgery was started, which lasted 45 min. The bitches were evaluated by the Modified Glasgow Scale (GSM), the Melbourne Scale (MS) and the Dobbins Sedation Scale (DS), previously administered MPA (T0) and the others performed in 1h (T1), 2h (T2), 4h (T3), 8h (T4), 12h (T5) and 24h (T6) after extubation. If the GSM score was greater than the value of 3.3 an analgesic rescue of 0.5 mg/kg of morphine intramuscularly would be administered. An increase in the scoring of pain scales in both groups can be observed from the T1, with significant difference only of the T1 in relation to the T0 in the GSM of the GDM. Two rescues were performed in T1 of GD and three rescues in T1 and a rescue in T3 of GDM. There was no significant difference between the groups in relation to this variable, as a result of P = 0.62. Discussion: Based on the results of this study, dexmedetomidine does not have adequate analgesic effect for use in preemptive analgesia of bitches submitted to elective OSH due to the high number of analgesic rescues. A small increase in GSM and MS scores from T1 can be expected compared to values prior to the surgical procedure since there was no nociceptive stimulation. This increase was only significant in T1 of GDM, moment of greatest rescue number (n = 3). The absence of significant difference between the groups proves that the analgesic effect of dexmedetomidine was not potentiated by the association with morphine at the do...

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Sobre a analgesia pós-operatória da morfina, cetamina ou da associação em cadelas submetidas à ovariossalpingohisterectomia eletiva

Abstract: Sobre a analgesia pós-operatória da morfi na, cetamina ou da associação em cadelas submetidas... Ciência Rural, v.43, n.7, jul, 2013. 1271Sobre a analgesia pós-operatória da morfi na, cetamina ou da associação em cadelas submetidas à ovariossalpingohisterectomia eletiva

Cited by 4 publications

References 25 publications

Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs

Preemptive effect of amantadine as adjuvant in postoperative analgesia of ovaryhisterectomy in dogs

Postoperative evaluation of analgesia promoted by the use of dexmedetomidine alone and associated with morphine as an intramuscular pre-anesthetic medication in bitches submitted for ovariohysterectomy

Evaluation of Postoperative Analgesia of DexmedetomidineAlone or Associated to Morphineas Premedicants in Bitches Undergoing Ovariosalpingohisterectomy

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