Genes termorregulados diferencialmente expressos em Conidiobolus lamprauges

Abstract

RESUMO Conidiobolus lamprauges

Epidemiological, clinical and diagnostic aspects of sheep conidiobolomycosis in Brazil

“…These fungi are characterized by producing asexual spores, which are relatively large globose (CHAYAKULKEEREE et al, 2006). SILVA et al (2012) also reported that C. lamprauges when exposed to temperature of 37°C overexpresses enolase, suggesting that this enzyme has potential involvement in host-pathogen relationship and virulence of this fungus. GODOY et al (2014) suggest that C. lamprauges produces a range of proteins that are related to thermoregulation triggered by the high temperature of the host.…”

“…infection (SILVA et al, 2007a). So far, no drug or chemical has been completely effective in the treatment of conidiobolomycosis (RIET-CORREA et al, 2008;KIMURA et al, 2011;SILVA et al, 2012). VALLE et al (2001) proposed a combination of triazoles, itraconazole and fluconazole, in the treatment of rhinomycosis by C. coronatus in humans; however, there are no reports of any effective treatment in sheep.…”

Expressão diferencial de proteínas do fungo Conidiobolus lamprauges cultivado em diferentes temperaturas

“…Recentemente, foi descrito, por meio da técnica de RDA, a expressão diferencial por C. lamprauges do gene que codifi ca a enolase, sendo que a exposição à temperatura elevada (37ºC) possivelmente esteja associada à superexpressão dessa proteína (SILVA et al, 2012).…”

Proteínas imunorreativas de Conidiobolus lamprauges isoladas de ovinos infectados naturalmente

“…Genes associados à virulência foram estudados na infecção do fungo em insetos (Freimoser et al 2003) e a sua capacidade de termo resistência em diferentes temperaturas (Silva et al 2012, Godoy et al 2014.…”