Compressão medular em bovinos associada à vacinação contra febre aftosa

Marques, Ana L.A.; Simões, Sara Vilar Dantas; Maia, Lisanka Ângelo; Silva, Tatiane Rodrigues da; Neto, Eldinê Gomes de Miranda; Pimentel, Luciano da Anunciação; Afonso, José Augusto Bastos; Dantas, Alexandre Cruz

doi:10.1590/s0103-84782012001000021

Cited by 7 publications

(4 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a retrospective study published by Marques et al [11], 24 cattle in Northeast Brazil developed gait abnormalities after vaccination against foot-and-mouth disease. Ubiali et al [18] reported an outbreak of lumbar compressive myelopathy in Central Brazil in which 25 cattle were affected approximately 60 days after oily adjuvant vaccines against foot-and-mouth disease were improperly administered.…”

Section: Discussionmentioning

confidence: 99%

“…Affected animals may present ataxia, inability to ambulate, incoordination, hypermetria, paresis, and paralysis [16]. Euthanasia is indicated in downer animals in permanent decubitus [11]. Sick animals may have difficulty to eat and move, requires special care and dedicated attention from staff, and develop a number of complications associated with prolonged recumbency such as pressure sores which negatively affect their well-being.…”

Section: Discussionmentioning

confidence: 99%

“…Iatrogenic postvaccinal injection site granulomas can affect animal welfare and production. They cause discomfort, production losses, reduction in live weight and carcass yield and ban on imports of fresh meat [1,5,10,11].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Iatrogenic Postvaccinal Injection Site Granulomas in Cattle

Folchini

Zanatta

Ugolini

et al. 2018

Acta Scientiae. Vet.

View full text Add to dashboard Cite

Background: The Brazilian government has established disease eradication and control programs to protect livestock from pathogens that affect animal health and compromise animal protein production and food safety and quality. Vaccination campaigns against foot-and-mouth disease and other infectious diseases in cattle except brucellosis can be carried out bynon-veterinarian employees. However, vaccination errors can result in the formation of granulomas at injection sites that can affect animal welfare and production. The present study aimed to report two cases of granulomas at injection sites due to the inadvertent administration of vaccines containing saponins and mineral oil as adjuvants.Cases: Case 1. The history was that a 2-year-old Devon steer was down for 7 days and was vaccinated 20 days ago with a vaccine containing saponins and mineral oil as adjuvants. Case 2. A 7-month-old Holstein heifer was examinated due to a 40-day history of ataxia, forelimb paresis progressing to tetraparesis, and vaccination with a vaccine containing saponins and mineral oil as adjuvants 60 days ago. These two animals were admitted in the Veterinary Hospital from the University of Passo Fundo (UPF) with a clinical history of incoordination and permanent decubitus after vaccination. The disease had a similar clinical course in both animals. Clinical signs included the presence of a palpable cervical mass at the site of vaccination, forelimb paresis that progressed to tetraparesis, and decubitus scars. Treatment included intravenousadministration of anti-inflammatory steroids, antibiotic therapy, daily cleansing of the pressure sores, all four limbs were massaged, animals underwent several physiotherapy sessions, slings were used to mantain recumbent patients in a standing position and supportive therapy consisted of fluid therapy and oral supplementation. Animals remained hospitalizedfor approximately 40 days. Pacients experienced temporary improvement during treatment, and would walk with an uncoordinated gait. The clinical picture worsened after treatment was discontinued, necessitating euthanasia. At necropsy, gross lesions were similar in both animals. In case 1, the trapezius was firm and pale and had multiple granulomas whichextended into the cervical vertebral column at C3-C4 and invaded the spinal canal compressing the spinal cord. In case 2, there was extensive damage to the trapezius by granulomatous inflammation; numerous nodular granulomas exuded milky contents. These lesions extended deep into the muscle fibers and infiltrated the vertebral column at C5-C6, with involvement of the medullary canal and spinal cord compression. Microscopically there was severe, diffuse pyogranulomatous myositis. Each pyogranuloma had a central clear space. Nodal architecture was effaced by these inflammatory nodules.Discussion: Some drugs and vaccines contain irritating adjuvants and induce granuloma formation at the inoculation site. In both cattle, vaccines were injected intramuscularly in the cranial third of the neck in close proximity to the cervical vertebrae and surrounding tissues. These vaccines possibly induced an exuberant inflammatory reaction at the inoculationsite. An exacerbated inflammatory response following the administration of adjuvanted vaccines by improperly trained personnel caused substantial tissue damage at the injection site. Severe, locally extensive lesions were found at necropsy affecting adjacent structures including skeletal muscles and spinal cord. The clinical signs of ataxia and forelimb paresis thatprogressed to tetraparesis were due to the marked pyogranulomatous inflammation in C3-C4 in case 1 and in C5-C6 in case 2. The present study reinforces the importance of good farming practices and properly trained personnel working at farms.Keywords: bovine, vaccine, infection site, granuloma, iatrogenic.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Iatrogenic Postvaccinal Injection Site Granulomas in Cattle

Folchini

Zanatta

Ugolini

et al. 2018

Acta Scientiae. Vet.

View full text Add to dashboard Cite

show abstract

“…Based on the sudden appearance of clinical signs in clinically healthy animals and the observation of traumas during management for vaccination and/or deworming, infectious diseases were excluded from the possible causes of the clinical conditions observed, especially rabies and botulism, which also produce clinical signs similar to those found in spinal cord compressions, abscesses and granulomas associated with vaccination for foot-and-mouth disease that require injections near the vertebrae (Ubiali et al 2011, Marques et al 2012, Brito 2017) and neoplastic masses in the vertebral canal caused by the enzootic bovine leukosis virus (Braga et al 1998).…”

Section: Discussionmentioning

confidence: 99%

Compressive lesions in the central nervous system of cattle: a retrospective study of 50 cases in the Amazon biome

et al. 2022

View full text Add to dashboard Cite

The present study gathered epidemiological and clinical-pathological information about cattle with compressive lesions in the central nervous system (CNS). The retrospective study included observations made in 50 cattle from 1998 to 2021 by reviewing the clinical records of animals with compressive lesions in the CNS treated at the Veterinary Hospital of the Veterinary Medicine Institute of the Federal University of Pará. The animals had clinical signs and were subjected to general and specific clinical examination of the nervous system. Blood samples were collected from 13 animals for complete blood counts, and cerebrospinal fluid (CSF) samples were collected from four animals for physical evaluation. Twenty-nine cattle underwent necropsy. The most affected sites were the T3-L3 (46%, 23/50), C1-C5 (22%, 11/50), C6-T2 (14%, 7/50), sacrococcygeal vertebrae, (4%, 2/50), L4-S2 (2%, 1/50), brain (8%, 4/50) and cerebellum (4%, 2/50). The age of the affected cattle ranged from 20 days to 16 years, with a higher occurrence in animals younger than 12 months (56%, 28/50). More Females were affected (58%, 29/50) than males (42%, 21/50). The clinical signs varied according to the location of the lesion and were mainly represented by ataxia, paresis or paralysis of the limbs, inability to stand and walk, postural changes, hyperesthesia in the extremities, and loss of skin sensitivity at the location of the lesion. The necropsy findings revealed changes such as abscesses in the vertebral body; intervertebral space in the medullary canal, pituitary and cerebellum; granuloma in the arch of the vertebra; fractures of the body of the vertebrae; subarachnoid haematoma; congenital bone alteration causing spinal cord compression; and spondylitis. Detailed anamnesis and clinical examination of the CNS, associated with necropsy findings, were important to determine the cause of the disease, correlate with the clinical picture and locate the affected segments of the CNS in the cattle. It is important to include these diseases in the list of differential diagnoses in cattle with nervous symptoms.

show abstract

An outbreak of compressive myelopathy due to pyogranulomatous reaction to the oily adjuvant of the foot-and-mouth disease vaccine - case report

Melo

Godoy

Filho

et al. 2019

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

Cases of compressive myelopathy syndrome associated with post vaccinal pyogranulomas were diagnosed post mortem in three cows from a farm in Minas Gerais state, Brazil. These cows presented ataxia and bilateral paresis of the pelvic limbs, which evolved to paralysis, and sternal recumbence. On necropsy, locally extensive areas of the longissimus dorsi muscle were replaced by pyogranulomas supported by moderate amounts of fibrous connective tissue. On the cut surface, some nodules contained yellowish and viscous fluid (purulent exudate) or whitish fluid (interpreted as the oily adjuvant of a vaccine). In the spinal canal of the subjacent vertebrae, compressing the spinal cord, were pyogranulomas identical to those described in the skeletal muscle. Histologically, the pyogranulomas were composed of a central clear vacuole (consistent with the space left by the oil adjuvant droplets), surrounded by neutrophils and, more externally, by large numbers of epithelioid macrophages and fewer multinucleated giant cells. In the white matter of the spinal cord were numerous well-defined, clear vacuoles (Wallerian degeneration). The association of the clinical history and pathological findings allowed the diagnosis of compressive myelopathy associated with pyogranulomatous reaction to the oily adjuvant of the foot-and-mouth disease vaccine, in this case, due to its inadequate application.

show abstract

Compressão medular em bovinos associada à vacinação contra febre aftosa

Abstract: IVCompressão medular em bovinos associada à vacinação contra febre aftosa Spinal cord compression in cattle associated whit vaccination against foot and mouth disease Recebido para publicação 01.12.11 Aprovado em 05.05.12 Devolvido pelo autor 20.07.12 CR-6413

Cited by 7 publications

References 5 publications

Iatrogenic Postvaccinal Injection Site Granulomas in Cattle

Iatrogenic Postvaccinal Injection Site Granulomas in Cattle

Compressive lesions in the central nervous system of cattle: a retrospective study of 50 cases in the Amazon biome

An outbreak of compressive myelopathy due to pyogranulomatous reaction to the oily adjuvant of the foot-and-mouth disease vaccine - case report

Contact Info

Product

Resources

About