Isolamento, fracionamento e avaliação toxicológica in vivo de polissacarídeos sulfatados de Hypnea musciformis

Rodrigues, José Ariévilo Gurgel; Araújo, Ianna Wivianne Fernandes de; Paula, Gabriela Almeida de; Vanderlei, Edfranck de Sousa Oliveira; Queiroz, Ismael Nilo Lino de; Quinderé, Ana Luíza Gomes; Coura, Chistiane Oliveira; Bessa, Érika Façanha; Lima, Ticiana de Brito; Benevídes, Norma Maria Barros

doi:10.1590/s0103-84782011005000094

Cited by 9 publications

(1 citation statement)

References 17 publications

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“…However, the histopathological lesions observed following CCl 4 administration were minimized with the administration of GB ( Figure 6(d) ) and vitamin E ( Figure 6(f) ). Rodrigues and colleagues [ 40 ] also observed that extracts from the red alga Hypnea musciformis also protected the renal tissue from CCl 4 -induced damage. The authors stated that the protective action of the alga is mainly due to the presence of the antioxidant sulfated polysaccharides in the extracts.…”

Section: Resultsmentioning

confidence: 99%

In VivoEvaluation of the Antioxidant Activity and Protective Action of the SeaweedGracilaria birdiae

Barros-Gomes

Nascimento

Silveira

et al. 2018

Oxidative Medicine and Cellular Longevity

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The red seaweed Gracilaria birdiae (GB) is farmed and used as food in northeast Brazil. However, the economic potential of this seaweed has been explored little. To enable direct consumption and/or product diversification from GB, it is necessary to evaluate its effect in vivo. In this study, the food of mice was improved with the addition of GB. After 21 days, the consumption of seaweed reduced the weight gain and blood glucose levels in mice. In addition, it increased the trolox equivalent antioxidant capacity and glutathione reductase and catalase levels compared to those of the control group. In addition, some mice also received carbon tetrachloride (CCl4). In this case, histological, enzymatic, and antioxidant tests showed that the seaweed could protect animals from damage caused by this toxic agent. In addition, GB aqueous extract (AE) inhibited 50% of 3T3-L1 cell differentiation into adipocytes, whereas GB ethanolic extract was not effective. AE is composed mainly of sulfated polysaccharides. The results of the present study indicate that the alga GB protected the mice from CCl4-induced damage, indicating that the seaweed exhibits protective action in vivo. In addition, GB decreased the animal weight gain, which was mainly due to the action of the sulfated polysaccharides synthesized by this seaweed.

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Section: Resultsmentioning

confidence: 99%

In VivoEvaluation of the Antioxidant Activity and Protective Action of the SeaweedGracilaria birdiae

Barros-Gomes

Nascimento

Silveira

et al. 2018

Oxidative Medicine and Cellular Longevity

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Orofacial antinociceptive effect of sulphated polysaccharide from the marine algae Hypnea pseudomusciformis in rodents

et al. 2018

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This study aimed to evaluate the antinociceptive effect of sulphated polysaccharide from the marine algae Hypnea pseudomusciformis (PLS) using rodent models of orofacial pain. Acute pain was induced by formalin, capsaicin, cinnamaldehyde, acidified saline or glutamate (cutaneous modes) and hypertonic saline (corneal model). In one experiment, animals were pretreated with ruthenium red, glibenclamide, naloxone, L-NAME, methylene blue or ketamine to investigate the mechanism of antinociception. In another experiment, animals pretreated with PLS or saline were submitted to the temporomandibular joint formalin test. In yet another, animals were submitted to craniofacial pain induced by mustard oil. Motor activity was evaluated with the open-field test. Cytotoxicity and antioxidant activities were also assessed. Pre-treatment with PLS significantly reduced nociceptive behavior associated with acute pain. Antinociception was effectively reduced, but not inhibited, by ruthenium red and ketamine. L-NAME and glibenclamide enhanced the PLS effect. PLS antinociception was resistant to methylene blue, naloxone and heating. PLS presented no cytotoxicity or antioxidant properties. Our results confirm the potential pharmacological relevance of PLS as an inhibitor of orofacial nociception in acute pain probably mediated by glutamatergic, nitrergic, TRPs and K + ATP pathways.

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Effects of nitrogen and phosphorus availabilities on growth, pigment, and protein contents in Hypnea cervicornis J. Agardh (Gigartinales, Rhodophyta)

et al. 2012

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Isolamento, fracionamento e avaliação toxicológica in vivo de polissacarídeos sulfatados de Hypnea musciformis

Cited by 9 publications

References 17 publications

In VivoEvaluation of the Antioxidant Activity and Protective Action of the SeaweedGracilaria birdiae

In VivoEvaluation of the Antioxidant Activity and Protective Action of the SeaweedGracilaria birdiae

Orofacial antinociceptive effect of sulphated polysaccharide from the marine algae Hypnea pseudomusciformis in rodents

Effects of nitrogen and phosphorus availabilities on growth, pigment, and protein contents in Hypnea cervicornis J. Agardh (Gigartinales, Rhodophyta)

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