Antioxidant and anti-inflammatory activities of winery wastes seeds of Vitis labrusca

Scola, Gustavo; Kappel, Virgínia Demarchi; Moreira, José Cláudio Fonseca; Dal‐Pizzol, Felipe; Salvador, Mirian

doi:10.1590/s0103-84782011000700020

Cited by 2 publications

(2 citation statements)

References 15 publications

(9 reference statements)

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“…T5500) and heated at 95 °C for 30 min (Scola et al. 2011 ). This reaction generated thiobarbituric acid reactive substances (TBARS), which are formed as by-products of lipid peroxidation.…”

Section: Methodsmentioning

confidence: 99%

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Healing effect ofDillenia indicafruit extracts standardized to betulinic acid on ultraviolet radiation-induced psoriasis-like wounds in rats

Kviecinski

David

Fernandes

et al. 2016

Pharmaceutical Biology

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Context: Dillenia indica Linn. (Dilleniaceae) is traditionally used to treat skin inflammation. Objective: This study evaluated the healing effect of Dillenia indica fruit extracts on induced psoriasis-like wounds in Wistar rats. Materials and methods: Extracts were standardized to betulinic acid, including an aqueous ethanolic extract (AEE), ethyl acetate extract (EAE) and petroleum ether extract. Effects against lipid peroxidation were assessed in vitro. Wounds were created at rat tails (n = 12). Topical treatments were applied once daily for 7 days (1 mL of AEE or EAE at 5 or 50 mg/mL). Maximal dose was defined by the extract solubility. A 10-fold lower dose was also tested. Positive and negative controls were treated with clobetasol (0.5 mg/mL) or excipient. Half of each group was euthanized for histology. The remaining animals were observed for 20 days for wound measurements. Results: Yields of AEE and EAE were 4.3 and 0.7%, respectively. Betulinic acid concentrations in AEE and EAE were 4.6 and 107.6 mg/g. Extracts neutralized lipid peroxidation in vitro at 0.02 μg/mL, accelerating healing at 50 mg/mL. Complete healing in mice treated with AEE occurred 16 days after wound induction. This time was 14 and 12 days in mice treated with EAE and clobetasol. Compared to orthokeratosis, parakeratosis was reduced by AEE (25%), EAE (45%) and clobetasol (55%). EAE caused superior protection against biomolecules oxidation of skin compared to AEE. Discussion and conclusion: EAE exhibited activity closer to that of clobetasol. Betulinic acid may be an active constituent, which should be assessed in future studies.

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Section: Methodsmentioning

confidence: 99%

“…The absorbance was measured at 532 nm (Scola et al. 2011 ). Data are expressed as concentrations (nmol) of MDA normalized by the protein content (Lowry et al.…”

Section: Methodsmentioning

confidence: 99%

Healing effect ofDillenia indicafruit extracts standardized to betulinic acid on ultraviolet radiation-induced psoriasis-like wounds in rats

Kviecinski

David

Fernandes

et al. 2016

Pharmaceutical Biology

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Flavan-3-ol compounds prevent pentylenetetrazol-induced oxidative damage in rats without producing mutations and genotoxicity

Scola

Scheffel

Gambato

et al. 2013

Neuroscience Letters

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Antioxidant and anti-inflammatory activities of winery wastes seeds of Vitis labrusca

Abstract: Palavras-chave: V. labrusca, resíduos de vinificação, antioxidante, anti-inflamatório.

Cited by 2 publications

References 15 publications

Healing effect ofDillenia indicafruit extracts standardized to betulinic acid on ultraviolet radiation-induced psoriasis-like wounds in rats

Healing effect ofDillenia indicafruit extracts standardized to betulinic acid on ultraviolet radiation-induced psoriasis-like wounds in rats

Flavan-3-ol compounds prevent pentylenetetrazol-induced oxidative damage in rats without producing mutations and genotoxicity

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