Seropositivity to Leptospira interrogans serovar Bratislava associated to reproductive problems without significant biochemical or hematological alterations in horses

Pinna, Melissa Hanzen; Martins, Gabriel; Freire, Isabel Maria Alexandre; Lilenbaum, Walter

doi:10.1590/s0103-84782010005000178

Cited by 18 publications

(15 citation statements)

References 6 publications

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“…Abortion, the most frequent reproductive problem associated with seroreactivity for leptospirosis, may be associated with placentitis (Szeredi and Haake 2006), whereas early embryonic and perinatal death, even when not generally perceived as being caused by leptospirosis, were also more common in seroreactive mares, consistent with the few reports regarding neonatal (Pinna and others 2007) or perinatal (Donahue and others 1995) deaths. Some similar findings have been reported in horses (Pinna and others 2010, Pinna and others 2012), deer (Subharat and others 2010), and cattle (Guitian and others 1999). Nevertheless, there are other reasons related to reproductive failures in horses, for example, age of mares; other infectious and non-infectious process; and inadequate nutrition.…”

Section: Discussionsupporting

confidence: 85%

“…This serovar is considered to be adapted to horses (Ellis and others 1983), and has already been reported (serology) in the studied region (Pinna and others 2007). Although further investigations are required, particularly those concerning recovery of the agent from clinical cases, seroreactivity against this serovar has been broadly associated with reproductive failure in horses, often without other clinical signs (Pinna and others 2010). Furthermore, the high prevalence of seroreactivity for serovar Copenhageni was not surprising, since members of Icterohaemorrhagiae serogroup represent the major agent of leptospirosis in many species, including horses in the tropics, particularly in Brazil (Hamond and others 2011)…”

Section: Discussionmentioning

confidence: 99%

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Potential differences between Leptospira serovars, host‐adapted (Bratislava) and incidental (Copenhageni), in determining reproductive disorders in embryo transfer recipient mares in Brazil

et al. 2014

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The objective was to investigate potential differences between two Leptospira serovars, host-adapted (Bratislava) and incidental (Copenhageni), in causing reproductive disorders in mares. From August 2009 to March 2011, 608 adult recipient mares from eight studs located in the state of Rio de Janeiro, Brazil, were screened for leptospirosis. These mares were 3-8 years of age, of various breeds, and were managed in a semiextensive system (embryo transfer centres). According to the reproductive history of these mares, the studs were categorised as Group A (357 mares: high prevalence of reproductive problems), and Group B (251 mares: all pregnant). Of the 608 samples tested serologically, 273 (44.9 per cent) were reactive (titres ≥200), predominantly against Bratislava (62.3 per cent of reactive mares). In Group A, 247/357 sera (69.2 per cent) were reactive, with reactivity against Bratislava (64.8 per cent of reactive). By contrast, in Group B, only 26/251 sera (10.4 per cent) were reactive, the majority against Copenhageni (61.5 per cent of reactive). Seroreactivity against Bratislava was more likely to be associated (P<0.001) with reproductive problems than seroreactivity against Copenhageni; this association was true for early embryonic death (P<0.001), perinatal death (P<0.01), and abortion (P<0.001). Additionally, 29 urine samples were collected (from Group A mares) for Leptospira species PCR, of which 16 were positive (55.2 per cent). We concluded that leptospirosis was associated with poor reproductive performance in embryo recipients, with the majority due to host-adapted Bratislava.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Potential differences between Leptospira serovars, host‐adapted (Bratislava) and incidental (Copenhageni), in determining reproductive disorders in embryo transfer recipient mares in Brazil

et al. 2014

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“…Decreased erythrocyte count, low Hb concentration, PCV, and lymphocytes are common lab findings (Tonin et al, 2012). Leucocytosis, neutrophilia, eosinopenia, and lymphopenia, along with high serum bilirubin concentration have also been reported in equine leptospirosis (Pinna et al, 2010). Laboratory evaluation of animals affected by leptospirosis can reveal hyperfibrinogenemia.…”

Section: Discussionmentioning

confidence: 99%

Frequency of leptospirosis in horses in Manaus and metropolitan region in Amazonas State, Brazil

Sousa

Silva

Sousa

et al. 2020

Braz. J. Vet. Res. Anim. Sci.

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The occurrence of leptospirosis is significantly higher in the tropical climate than in temperate regions, especially in periods with high rainfall levels. In horses, leptospirosis can range from subclinical to asymptomatic but maintains an important role in the transmission of leptospirosis by eliminating the agent in the environment. Regarding horses, the Amazonas herd increased by 30% between 2004 and 2013. Thus, the study aimed to determine the serological prevalence of leptospirosis in horses in Manaus and metropolitan regions, in the State of Amazonas, Brazil as well as to assess the main serogroups involved in the infections of these animals. For this purpose, from August 2018 to July 2019, serum from 198 horses was evaluated through the microscopic agglutination test with a panel of 10 serogroups. As a result, 92 horses (44.46%) were found to be positive for one or more Leptospira serovars, with the highest prevalence of serogroups Icterohaemorrhagiae and Pyrogenes. Therefore, with the increase in the equine herd in the region and, consequently, greater interaction between breeders and animals, the identification of reagents to at least one serovar of Leptospira spp. signals the possible existence of reservoirs of pathogenic strains for other animals and man.

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“…Bratislava, mesmo na presença de problemas reprodutivos, não apresentaram alteração consistentes ou importantes para os valores de hematologia e bioquímica sérica (Pinna et al, 2010), assim como os resultados encontrados neste estudo.…”

Section: Methodsunclassified

Metabolismo Oxidativo E Alterações Hematobioquímicas Em Equinos Com Leptospirose Subclínica

Farias

Lovatel

Dalmina

et al. 2020

AVS

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A leptospirose é uma doença infectocontagiosa de caráter zoonótico, que afeta animais domésticos e silvestres, com grande importância para a saúde pública mundial. Nos animais, especialmente equinos, a doença se apresenta frequentemente de forma assintomática, entretanto, são considerados uma fonte de infecção para humanos e outras espécies. O presente estudo objetivou avaliar padrões do metabolismo oxidativo eritrocitário (glutationa e malondialdeído), fragilidade osmótica eritrocitária e hematobioquímicos em equinos com leptospirose subclínica para auxiliar no diagnóstico e prognóstico da infecção. Para tal foram avaliados 207 equinos, positivos (n=94) e negativos (n= 113) para leptospirose. Os equinos com leptospirose apresentaram mais frequentemente anticorpos anti-leptospira dos sorogrupos L. Bratislava 37,23% (35/94), L. Icterohaemorrhagiae 23,4% (22/94) e L. Grippotyphosa 11,7% (11/94). As principais alterações observadas foram nos valores de hemoglobina, VGM, eosinófilos, glutationa reduzida eritrocitária, albumina e glicose (P<0,05). Estas alterações evidenciam que a leptospirose em equinos pode ser uma doença silenciosa, de difícil diagnóstico e prognóstico. Entretanto, as medidas de diagnóstico e vigilância devem ser ativas, pois os animais podem representar um reservatório para o agente e uma fonte potencial de infecção para seres humanos.

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Seropositivity to Leptospira interrogans serovar Bratislava associated to reproductive problems without significant biochemical or hematological alterations in horses

Cited by 18 publications

References 6 publications

Potential differences between Leptospira serovars, host‐adapted (Bratislava) and incidental (Copenhageni), in determining reproductive disorders in embryo transfer recipient mares in Brazil

Potential differences between Leptospira serovars, host‐adapted (Bratislava) and incidental (Copenhageni), in determining reproductive disorders in embryo transfer recipient mares in Brazil

Frequency of leptospirosis in horses in Manaus and metropolitan region in Amazonas State, Brazil

Metabolismo Oxidativo E Alterações Hematobioquímicas Em Equinos Com Leptospirose Subclínica

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