Fisiopatologia das diarréias em suínos

Vannucci, Fábio A.; Guedes, Roberto Maurício Carvalho

doi:10.1590/s0103-84782009005000163

Cited by 4 publications

(3 citation statements)

References 71 publications

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“…Presentation of medication in injectable form, as used in the present study, is advantageous, because it enables its complete absorption, ensuring that the animal receives the entire necessary dose (Karriker et al 2012). Animals infected with L. intracellularis present with atrophy and fusion of the villi, with reduction of digestive enzymes, and inhibition of membrane transporters, mechanisms that lead to malabsorption diarrhea (Argenzio 1980, Vannucci & Guedes 2009), suggesting that it may result in low antibiotic uptake when this is administered orally. Intramuscular medication has another advantage compared with in-feed medication, because ill animals show lower feed intake (Apley et al 2012).…”

Section: Table 2 Comparison Between Mean Weight Of Animals In the Comentioning

confidence: 99%

Tylosin injectable for the treatment of porcine proliferative enteropathy in experimentally inoculated pigs

et al. 2019

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Porcine proliferative enteropathy (PPE) is one of the most common enteric diseases in growing and finishing pigs. PPE is characterized by reduced growth performance, accompanied or not by diarrhea. PPE is highly prevalent in several countries of the Americas, Europe and Asia, causing high economic losses in swine herds. The most common form of PPE control in pigs is antibiotic therapy. The objective of this study was to evaluate a new product based on tylosin injectable (Eurofarma Laboratórios S.A.) to control PPE in experimentally inoculated animals. Sixty 5-week-old pigs with mean weight of 9.5kg were divided into two experimental groups of 30 animals: medication and control. All pigs were challenged with Lawsonia intracellularis, the etiologic agent of PPE, on day zero. Fecal score, body condition score, and behavior were daily evaluated. Pigs were weighted on days -2, 13 and 21 of the experiment. Pigs in the Medication Group received tylosin injectable 13 days after inoculation, in three doses with a 12-hour interval between them. Pigs in the Control Group received injectable saline solution following the same protocol. In the Control Group, 23pigs presented with diarrhea before day 13. After day 13, the number of diarrheic animals in this group was reduced to 17. In the Medication Group, 26 pigs presented with diarrhea in the initial period, and in the period after medication, only 11 animals had diarrhea. The score of gross intestinal PPE lesions in the Medication Group was lower than that in the Control Group (p=0.031). The Medication Group also showed lower score for Lawsonia intracellularis antigen-labeling by immunohistochemistry compared with that of the Control Group (p=0.032), showing lower level of infection. These results demonstrate that tylosin injectable (Eurofarma Laboratórios S.A.), administrated in three doses (1mL/20kg) every 12 hours, was effective for the control of PPE in experimentally inoculated pigs.

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Section: Table 2 Comparison Between Mean Weight Of Animals In the Comentioning

confidence: 99%

Tylosin injectable for the treatment of porcine proliferative enteropathy in experimentally inoculated pigs

et al. 2019

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“…The gastrointestinal tract immaturity of piglets affects the intestinal architecture and compromises the absorption and secretion. This impairs intestinal health of piglets, favours pathogenic microorganisms proliferation (Oetting et al, 2006), and hence the occurrence of post-weaning diarrhoea (Vannucci & Guedes, 2009). Being responsible for a marked reduction in the health of pigs, post-weaning diarrhoea is a widespread problem that affects swine production in the whole world (Zhang et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Effect of functional oil in piglet feeding and its effects on total blood count, health parameters, and gastrointestinal tract structure

Santos¹,

Genova²,

Lima³

et al. 2023

SA J. An. Sci.

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This study was performed to evaluate the effects of a functional oil blend (castor oil plus cashew nutshell oil) on complete blood count, health parameters, and intestinal structure in nursery pigs. A total of 128 crossbreed piglets (6.79 ± 1.76 kg of body weight) were allocated in a randomized complete block design with two dietary treatments: a functional oil-free diet or a diet based on added functional oil (1500 mg functional oil blend/kg of diet). Both diets had 400–500 mg colistin sulphate/kg. Pigs fed functional oil had higher erythrocytes and monocytes on days 11 and 23, respectively. Lymphocyte concentration was reduced, and ileum pH was increased in pigs fed functional oil on day 23. On day 37, lower jejunal pH was observed. However, no treatment effect on diarrhoea occurrence was observed. The lactic acid bacteria count was greater in jejunum and ileum of pigs fed functional oil on day 23. Pigs fed functional oil had more jejunal lesions on day 37. Based on the criteria of this study, dietary supplementation to piglets with functional oil blend changed the concentration of erythrocytes and monocytes as an important role in the defence of the organism; however, it showed a reduced capacity to modify the pH in small intestinal contents, which was reflected in an absence in the incidence of diarrhoea. In addition, piglets fed the functional oil blend had improvements in lactic acid bacterial counts, without the ability to attenuate lesions in the jejunum.

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“…Consequently, ingested and undigested nutrients serve as nutritive substances for the colon bacteria and, therefore, increase the pathogenic intestinal microbiota, resulting in diarrhoea and even mortality. The occurrence of diarrhoea may involve various mechanisms, such as changes in the water and electrolyte absorption, increased permeability of the epithelial barrier and activation of inflammatory processes (VANUCCI; GUEDES, 2009). The occurrence of post-weaning diarrhoea, allied with the European Union's prohibition on the use of antibiotics and chemotherapeutics as performance enhancers, may intensify the occurrence of enteric problems in the nursery phase and increase economic loss in pig production.…”

Section: Introductionmentioning

confidence: 99%

Additional effect of coated sodium butyrate 30% in the piglets feeding during the nursery phase

Oliveira

Carvalho

Junior

et al. 2018

SCA

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In this study, the objective was to assess the growth performance, rectal microbiological profile, serum and immunological standards, and incidence of diarrhoea in piglets in the nursery phase fed diets with and without the addition of coated sodium butyrate 30% (SB). A total of 80 crossbred piglets (40 entire males and 40 females), with an average initial body weight of 9.47 ± 1.03 kg, were distributed in a randomised block design, with four treatments repeated twice in the two blocks and five piglets of the same gender per experimental unit. The treatments comprised a combination of two feeds, formulated based on corn and soybean meal with and without 0.1% SB inclusion as an additional product, and both genders, fed from of the pre-starter I diet. SB did not affect (p > 0.05) the growth performance and rectal microbiological profile of the piglets, but efficiently (p = 0.05) controlled the incidence of diarrhoea. The average values of the characteristics measured in the blood of the piglets were within the normal physiological parameters of the species. The inclusion of SB in commercial feed did not alter the growth performance and rectal microbiological profile of nursery piglets under low sanitary challenge conditions. However, the organic acid efficiently reduced gastrointestinal disorders that cause diarrhoea, with diarrhoea incidence rates of 2.68 and 4.46% for piglets fed with and without the inclusion of the additional organic acid, respectively.

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Fisiopatologia das diarréias em suínos

Abstract: A diarréia é a principal manifestação clínica das infecções entéricas. O desequilíbrio entre os processos de

Cited by 4 publications

References 71 publications

Tylosin injectable for the treatment of porcine proliferative enteropathy in experimentally inoculated pigs

Tylosin injectable for the treatment of porcine proliferative enteropathy in experimentally inoculated pigs

Effect of functional oil in piglet feeding and its effects on total blood count, health parameters, and gastrointestinal tract structure

Additional effect of coated sodium butyrate 30% in the piglets feeding during the nursery phase

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