Choroid plexus carcinoma in a cow

Sant’Ana, Fabiano José Ferreira de; Gabriel, Adriane L.; Kommers, Gláucia D.; Barros, Claudio S.L.

doi:10.1590/s0103-84782009005000150

Cited by 2 publications

(3 citation statements)

References 14 publications

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“…In people, choroid plexus tumors represent approximately 0.4–0.6% of all brain tumors 2 . Although these tumors are also uncommon in animals, they comprise 10% of all primary intracranial tumors of the central nervous system 3 and have been previously described most frequently in dogs, but also in cats, horses, cows, goats, and ferrets 3–18 . In dogs, middle‐aged animals appear to be more commonly affected, and, in contrast to previous reports of a higher incidence in males, 9 more recent studies indicate an equal male to female ratio 13,16 .…”

Section: Discussionmentioning

confidence: 91%

“…2 Although these tumors are also uncommon in animals, they comprise 10% of all primary intracranial tumors of the central nervous system 3 and have been previously described most frequently in dogs, but also in cats, horses, cows, goats, and ferrets. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] In dogs, middleaged animals appear to be more commonly affected, and, in contrast to previous reports of a higher incidence in males, 9 more recent studies indicate an equal male to female ratio. 13,16 In people, approximately 80% of choroid plexus tumors are benign and classified as papillomas, whereas the remaining 20% are reported as carcinomas.…”

Section: Discussionmentioning

confidence: 99%

“…Previously reported cases of choroid plexus tumors were diagnosed at postmortem histopathologic examination 4,7,12,14,17,21 or by examination of wedge biopsies and cytologic squash preparations collected during neurosurgical procedures 6,15 . More recently, the cytologic reevaluation of archived CSF samples in a retrospective study demonstrated the presence of atypical cells attributable to choroid plexus epithelium, 16 highlighting the diagnostic value of examining CSF.…”

Section: Discussionmentioning

confidence: 99%

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Choroid plexus carcinoma cells in the cerebrospinal fluid of a Staffordshire Bull Terrier

Pastorello

Constantino‐Casas

Archer

2010

Veterinary Clinical Pathol

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An 11-year-old female intact Staffordshire Bull Terrier was referred to the Queen's Veterinary School Hospital at the University of Cambridge with sudden onset of episodic behavioral changes, a mammary mass, and papilledema in the right eye. On physical examination the dog appeared depressed and had a head tilt to the right with anisocoria. Using magnetic resonance imaging, a broad-based lesion that obliterated the fourth ventricle was detected in the right brainstem. There was no evidence of pulmonary metastasis. Cerebrospinal fluid (CSF) was then obtained; fluid analysis showed an increased cell count (165 cells/μL, reference interval 0-7 cells/μL) and total protein (0.30 g/L, reference value <0.25 g/L). Cytologic evaluation revealed a population of atypical epithelial cells arranged in cohesive rafts and characterized by moderate to occasionally marked anisocytosis and anisokaryosis. The appearance was highly suspicious of a malignant epithelial neoplasm. The dog was euthanized and on postmortem examination an asymmetrical nonencapsulated cerebellar mass was found within the choroid plexus of the fourth ventricle with local extension into the cerebellopontine angle. Histologic sections of the cerebellar mass contained arborizing papillary structures covered by a single layer of atypical epithelial cells that showed local infiltration into the adjacent neuropil. The diagnosis was choroid plexus carcinoma. The atypical epithelial cells were negative for pancytokeratin and strongly positive for vimentin. The finding of clusters of choroid plexus epithelial cells in the CSF demonstrates the value of utilizing a relatively noninvasive diagnostic technique for diagnosis of choroid plexus tumors.

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Section: Discussionmentioning

confidence: 91%