Anemia hemolítica imunomediada não regenerativa em um cão

Brandão, Leonardo Pinto; Ikesaki, Júlia Yuzuki Habu; Miyashiro, Samantha Ive; Franchini, Maria Luísa; Hagiwara, Mitika Kuribayashi

doi:10.1590/s0103-84782004000200034

Cited by 40 publications

(41 citation statements)

References 10 publications

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“…PRCA is primarily treated with immunosuppressants. 4,6 Brandão et al 8 recommended the administration of prednisone (2 mg/kg every 12 hours) and azathioprine (2 mg/kg every 24 hours) in the treatment of nonregenerative immuno-mediated hemolytic anemia. Those doses were like the doses prescribed in this case report.…”

Section: Discussionmentioning

confidence: 99%

“…4,6 Azathioprine can be given at a dose of 2 mg/kg every 24 hours. 7 Although their efficacy has not been well studied in dogs, erythropoiesis-stimulating agents such as all-trans retinoic acid, 8 oxymetholone, thymomodulin, 9 and nandrolone, 10 can also be administered in cases where immunosuppressants do not provide the expected therapeutic effect. Nandrolone decanoate is a synthetic androgen with anabolic effects, and is capable of stimulating cell growth and resistance.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Use of Nandrolone Decanoate in Treatment of Pure Red Cell Aplasia Secondary to Diclofenac Administration: A Case Report

Marchi

Vieira

Ribeiro

et al. 2017

Topics in Companion Animal Medicine

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Pure red cell aplasia (PRCA) is a disorder that leads to a nonregenerative anemia that results from erythroid precursors failing to reach maturity in the bone marrow, whereas the numbers of mature myeloid and megakaryocytic cells remain normal. PRCA can be induced by autoimmune processes, infections, drugs, toxins, and radiation, and is diagnosed by a bone marrow cytology examination after excluding the most common causes of nonregenerative anemia. Immunosuppressive therapies are used to treat PRCA, and usually involve the use of glucocorticoids, cyclosporin, or azathioprine. Alternatively, although little studied in veterinary medicine, drugs which stimulate bone marrow (e.g., nandrolone decanoate) have been mentioned as possible therapeutic agents. A case of PRCA that presented at the Veterinary Teaching Hospital of the Faculty of Veterinary Medicine and Animal Science (UNESP)-Botucatu, Brazil showed a good therapeutic response to weekly administration of nandrolone decanoate. Therefore, it was concluded that bone marrow stimulants might improve the quality of life of PRCA patients, provided they are used with caution and under close clinical supervision.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Use of Nandrolone Decanoate in Treatment of Pure Red Cell Aplasia Secondary to Diclofenac Administration: A Case Report

Marchi

Vieira

Ribeiro

et al. 2017

Topics in Companion Animal Medicine

View full text Add to dashboard Cite

show abstract

“…O tratamento de animais com anemia hemolítica deve ser realizado por meio de transfusão sanguínea ou uso de medicações visando corrigir o quadro anêmico e concomitante a este deverá ser instituído um tratamento para tratar a causa primária incitante, seja esta por condições infeciosas, inflamatórias, toxicológicas ou imunológicas (BRANDÃO, HAGIWARA, FRANCHINI, 2003).…”

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