Moraxella bovis: influência das características genotípicas e fenotípicas no controle da ceratoconjuntivite infecciosa bovina

Abstract

A Ceratoconjuntivite Infecciosa Bovina (CIB) continua sendo a mais importante enfermidade ocular dos bovinos da região do MERCOSUL. O agente etiológico da CIB, a bactéria Moraxella bovis, apresenta diferenças genéticas que determinam variações antigênicas e de susceptibilidade aos fármacos, que dificultam seu controle. São discutidos, neste trabalho, resultados de estudos moleculares, antigênicos e de susceptibilidade a antimicrobianos realizados com cepas isoladas durante os últimos vinte anos na região e comparados com os de outras regiões.Palavras-chave: CIB, Moraxella bovis, diversidade antigênica, perfis moleculares. ABSTRACTInfectious Bovine Keratoconjunctivitis (IBK) is still the most important ocular disease of cattle in the MERCOSUL region. The etiologic agent of IBK, the bacterium Moraxella bovis, has genetic differences responsible for antigenic and antibiotic susceptibility variability that interfere in its control. In this review, molecular, antigenic and antimicrobial susceptibility studies of strains recovered during the last 20 years in our region are discussed and compared with results obtained abroad.

Moraxella bovoculi em casos de ceratoconjuntivite infecciosa bovina no Rio Grande do Sul

“…No Brasil, M. bovis e M. ovis têm sido alvo de relatos e pesquisas (Conceição & Turnes 2003, Chaves et al 2008, Carmo et al 2011 …”

Genome‐wide association study of resistance/susceptibility to infectious bovine keratoconjunctivitis in Brazilian Hereford cattle

“…Consequently, there is a predisposition to the installation of M . bovis bacteria in the bovine ocular conjunctiva due to UV radiation (Conceição & Turnes 2003). Three genes ( PRF1 , SPP1 , and TRPC4 ) found among the candidates are associated with the immune response and/or the healing process of eye injuries (Osínka et␣al .…”

“…It worth mentioning that IBK outbreaks occur frequently between the end of spring and early summer, which coincides with the increased photoperiod and thus, greater incidence of sunlight on the retina, with potential to superficially damage the bovine eye. Consequently, there is a predisposition to the installation of M. bovis bacteria in the bovine ocular conjunctiva due to UV radiation (Conceic ¸ão & Turnes 2003). Three genes (PRF1, SPP1, and TRPC4) found among the candidates are associated with the immune response and/or the healing process of eye injuries (Osı ´nka et al 2014;Reinach et al 2015;Icer & Gezmen-Karadag 2018).…”

Genetic differences among Moraxella bovis and Moraxella bovoculi isolates from infectious bovine keratoconjunctivitis (IBK) outbreaks in southern Brazil

“…IBK was diagnosed in most Brazilian states and is widely disseminated in the southern region of Rio Grande do Sul state (Turnes, 2001), mainly affecting taurine bovines (Conceição and Turnes, 2003). It is a seasonal disease, with a worldwide distribution and, generally, highly prevalent (McConnel et al, 2007).…”