Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized rats

Freitas, Deborah Queiroz; Ramos‐Perez, Flávia Maria de Moraes; Neves, Ellen Gaby; Marques, Marcelo Rocha; Bóscolo, Frab Norberto; Almeida, Solange María de

doi:10.1590/s0103-64402012000600017

Cited by 8 publications

(9 citation statements)

References 22 publications

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“…This difference was not observed in the measurements of the mandibular teeth, once again demonstrating that sodium selenite did not have a radioprotective action. This finding is in agreement with the study by Rocha et al (6), in which sodium selenite was not an effective radioprotector at 7 and 14 days of evaluation in bone tissue, but it is contrary to the outcomes of different studies (7,8,16,(18)(19)(20)(21).…”

Section: Discussionsupporting

confidence: 92%

Radioprotective Effect of Sodium Selenite on Developing Teeth

et al. 2013

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Radioprotective agents like selenium are used to reduce the damage caused by radiation in healthy tissues. The aim of this study was to evaluate the effect of sodium selenite on the development of the molars of offspring of rats irradiated during odontogenesis. Twenty pregnant rats were randomly divided into 4 groups: control, irradiated, selenium and selenium/irradiated. The selenium and selenium/irradiated groups received 0.3 mg/kg of sodium selenite at 18 days of pregnancy. The rats of the irradiated and selenium/irradiated groups received a single dose of 4 Gy of X rays on the abdominal region at the 19th day of pregnancy. The offspring was sacrificed at 3 and 4 days after birth for evaluation of the birefringence of the enamel organic matrix, and at 30 days for evaluation of the intercuspal dimensions of the molars. The selenium/irradiated group was similar to the irradiated group with respect to the thickness and irregularity of the enamel organic matrix region in the evaluated birefringence, as the intercuspal dimensions of the molars. In conclusion, sodium selenite had no radioprotective action on the development of the molars of offspring of rats irradiated during odontogenesis and had a toxic effect in the initial time.

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Section: Discussionsupporting

confidence: 92%

Radioprotective Effect of Sodium Selenite on Developing Teeth

et al. 2013

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“…41,42 Furthermore, selenium aids the recovery of radiosensitive organs like bone marrow after exposure to high doses of radiation. 43 Treatment with 1.6 mg/kg selenium increased the 30-day survival of mice after irradiation with 22 Gy. Furthermore, selenium treatment could attenuate the toxicity of amifostine and also increased the dose reduction factor from 2.2 to 2.6.…”

Section: Selenium As Radioprotectormentioning

confidence: 96%

“…Selenium analogs have been proposed for the protection of radiosensitive organs to increase the survival rate and improve quality of life of radiotherapy patients . Furthermore, selenium aids the recovery of radiosensitive organs like bone marrow after exposure to high doses of radiation . Treatment with 1.6 mg/kg selenium increased the 30‐day survival of mice after irradiation with 22 Gy.…”

Section: Selenium As Radioprotectormentioning

confidence: 99%

Selenium as an adjuvant for modification of radiation response

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Mortezaee

Motevaseli

et al. 2019

J of Cellular Biochemistry

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Ionizing radiation plays a central role in several medical and industrial purposes. In spite of the beneficial effects of ionizing radiation, there are some concerns related to accidental exposure that could pose a threat to the lives of exposed people. This issue is also very critical for triage of injured people in a possible terror event or nuclear disaster. The most common side effects of ionizing radiation are experienced in cancer patients who had undergone radiotherapy. For complete eradication of tumors, there is a need for high doses of ionizing radiation. However, these high doses lead to severe toxicities in adjacent organs. Management of normal tissue toxicity may be achieved via modulation of radiation responses in both normal and malignant cells. It has been suggested that treatment of patients with some adjuvant agents may be useful for amelioration of radiation toxicity or sensitization of tumor cells. However, there are always some concerns for possible severe toxicities and protection of tumor cells, which in turn affect radiotherapy outcomes. Selenium is a trace element in the body that has shown potent antioxidant and radioprotective effects for many years. Selenium can potently stimulate antioxidant defense of cells, especially via upregulation of glutathione (GSH) level and glutathione peroxidase activity. Some studies in recent years have shown that selenium is able to mitigate radiation toxicity when administered after exposure. These studies suggest that selenium may be a useful radiomitigator for an accidental radiation event. Molecular and cellular studies have revealed that selenium protects different normal cells against radiation, while it may sensitize tumor cells. These differential effects of selenium have also been revealed in some clinical studies. In the present study, we aimed to review the radiomitigative and radioprotective effects of selenium on normal cells/tissues, as well as its radiosensitive effect on cancer cells.

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“…In order to mitigate oral complications, many radiationprotective agents have been studied with the aim of reducing the side effects due to radiotherapy on normal cells (5)(6)(7)(8)(9)(10)(11). Possible radioprotective effects of non-steroidal anti-inflammatory drugs (NSAIDs) have been researched recently and positive results have been observed (5,6,10).…”

Section: Introductionmentioning

confidence: 99%

Meloxicam as a Radiation-Protective Agent on Mandibles of Irradiated Rats

et al. 2017

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This study evaluated the action of ionizing radiation and the possible radioprotective effect of the non-steroidal anti-inflammatory drug meloxicam on the bone physiology of rat mandibles by assessing the alveolar socket healing and bone strength. Forty male Wistar rats were divided in 4 groups (n=10): control (CG), irradiated (IG), meloxicam (MG), meloxicam irradiated (MIG). A dose of 0.2 mg/kg meloxicam was administered to MG and MIG. After this, IG and MIG were irradiated with 15 Gy radiation dose in the mandible. Forty days after the above procedures, the mandibular first molars were extracted and the animals were killed after 15 or 30 days (n=5). Micro-computed tomography and bending test were used to evaluate alveolar socket healing and bone strength, respectively. At 15 days, bone volume, bone volume fraction and trabecular thickness were higher in the CG and MG than in the IG and MIG; and trabecular separation was higher in the IG compared with the others. At 30 days, there was a difference only in trabecular separation, which was higher in IG than in CG and MG, and MIG did not differ from the others. Bone strength was lower in IG compared with CG and MG, and MIG did not differ from the others. In conclusion, the ionizing radiation affected the bone physiology of rat mandibles, delaying the alveolar socket healing and reducing the bone strength. Moreover, the meloxicam had a positive effect on the trabecular separation in alveolar socket healing and on the bone strength.

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Radioprotective effect of sodium selenite on bone repair in the tibia of ovariectomized rats

Cited by 8 publications

References 22 publications

Radioprotective Effect of Sodium Selenite on Developing Teeth

Radioprotective Effect of Sodium Selenite on Developing Teeth

Selenium as an adjuvant for modification of radiation response

Meloxicam as a Radiation-Protective Agent on Mandibles of Irradiated Rats

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