Biocompatibility evaluation of a new bioresorbable pin for membrane fixation

Cestari, Tânia Mary; Oliveira, Rodrigo Cardoso de; Sanada, Jefferson Tomio; Garlet, Gustavo; Taga, Rumio; Granjeiro, José Mauro

doi:10.1590/s0103-64402010000600002

Cited by 5 publications

(5 citation statements)

References 19 publications

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“…The giant cells, considered as foreign body type giant cells, are of monocyticphagocytic lineage and are important in the tissue repair mechanism, as they carry out cellular and tissue debris phagocytose, as well as contribute to the bioabsorption of biomaterial fragments, besides secreting cytokines that favor essential cellular events in tissue repair. The presence of multinucleated giant cells modulated by the chemical surface of the biomaterials 2 has demonstrated the importance of macrophage subsets in the reaction to foreign bodies and, consequently, in the biocompatibility of biomaterials 6 , 7 . Therefore, the presence of these cells can occur as an attempt to reabsorb the material, which not necessarily implies lack of biocompatibility.…”

Section: Discussionmentioning

confidence: 99%

Alveolar bone repair with strontium- containing nanostructured carbonated hydroxyapatite

et al. 2018

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ObjectiveThis study aimed to evaluate bone repair in rat dental sockets after implanting nanostructured carbonated hydroxyapatite/sodium alginate (CHA) and nanostructured carbonated hydroxyapatite/sodium alginate containing 5% strontium microspheres (SrCHA) as bone substitute materials.MethodsTwenty male Wistar rats were randomly divided into two experimental groups: CHA and SrCHA (n=5/period/group). After one and 6 weeks of extraction of the right maxillary central incisor and biomaterial implantation, 5 μm bone blocks were obtained for histomorphometric evaluation. The parameters evaluated were remaining biomaterial, loose connective tissue and newly formed bone in a standard area. Statistical analysis was performed by Mann-Withney and and Wilcoxon tests at 95% level of significance.ResultsThe histomorphometric results showed that the microspheres showed similar fragmentation and bio-absorbation (p>0.05). We observed the formation of new bones in both groups during the same experimental periods; however, the new bone formation differed significantly between the weeks 1 and 6 (p=0.0039) in both groups.ConclusionThe CHA and SrCHA biomaterials were biocompatible, osteoconductive and bioabsorbable, indicating their great potential for clinical use as bone substitutes.

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Section: Discussionmentioning

confidence: 99%

Alveolar bone repair with strontium- containing nanostructured carbonated hydroxyapatite

et al. 2018

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“…These are used for membrane fixation to the local jawbone and support both the insertion and fixation of bone substitute material (BSM). Securing the membrane with pins or screws maximizes the stability of the membrane and allows for a significantly enhanced bone formation [19,20]. Due to their stability, non-resorbable titanium-based pins are still the gold standard in dentistry; however, it is usually required to remove the titanium pins during a second surgery.…”

Section: Introductionmentioning

confidence: 99%

“…Due to their stability, non-resorbable titanium-based pins are still the gold standard in dentistry; however, it is usually required to remove the titanium pins during a second surgery. Alternative resorbable pins have been developed to overcome the necessity for pin removal and have been introduced onto the market [19,[21][22][23]. For example, biodegradable polymer pins based on polyglycolic acid (PGA), polylactic acid (PLA) and other homopolymers and copolymers have been studied to replace titanium devices [24,25].…”

Section: Introductionmentioning

confidence: 99%

“…For example, biodegradable polymer pins based on polyglycolic acid (PGA), polylactic acid (PLA) and other homopolymers and copolymers have been studied to replace titanium devices [24,25]. Additionally, pins obtained from decellularized human or bovine cortical bone have been described [19]. However, the application of these resorbable pins has been associated with different issues, such as a low biocompatibility (e.g., due to the degradation products) or a lack of mechanical functionality for maintaining a secure fixation [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

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Biocompatibility Analyses of HF-Passivated Magnesium Screws for Guided Bone Regeneration (GBR)

Jung

Hesse²,

Stojanović

et al. 2021

IJMS

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Background: Magnesium (Mg) is one of the most promising materials for human use in surgery due to material characteristics such as its elastic modulus as well as its resorbable and regenerative properties. In this study, HF-coated and uncoated novel bioresorbable magnesium fixation screws for maxillofacial and dental surgical applications were investigated in vitro and in vivo to evaluate the biocompatibility of the HF coating. Methods: Mg alloy screws that had either undergone a surface treatment with hydrofluoric-acid (HF) or left untreated were investigated. In vitro investigation included XTT, BrdU and LDH in accordance with the DIN ISO 10993-5/-12. In vivo, the screws were implanted into the tibia of rabbits. After 3 and 6 weeks, degradation, local tissue reactions and bony integration were analyzed histopathologically and histomorphometrically. Additionally, SEM/EDX analysis and synchrotron phase-contrast microtomography (µCT) measurements were conducted. The in vitro analyses revealed that the Mg screws are cytocompatible, with improved results when the surface had been passivated with HF. In vivo, the HF-treated Mg screws implanted showed a reduction in gas formation, slower biodegradation and a better bony integration in comparison to the untreated Mg screws. Histopathologically, the HF-passivated screws induced a layer of macrophages as part of its biodegradation process, whereas the untreated screws caused a slight fibrous tissue reaction. SEM/EDX analysis showed that both screws formed a similar layer of calcium phosphates on their surfaces and were surrounded by bone. Furthermore, the µCT revealed the presence of a metallic core of the screws, a faster absorbing corrosion front and a slow absorbing region of corroded magnesium. Conclusions: Overall, the HF-passivated Mg fixation screws showed significantly better biocompatibility in vitro and in vivo compared to the untreated screws.

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“…Том 21 № 3. 2022 Таким образом, результаты исследования, полученные авторами через 12 месяцев после оперативного лечения, позволяют обоснованно присоединиться к мнению отечественных и зарубежных коллег, использующих дополнительную фиксацию пародонтологической мембраны пинами, особенно, как представлено в данном исследовании, при дефектах сложной конфигурации [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30].…”

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Analysis of wound discharge microbiota in patients with drug-associated osteonecrosis of the jaw

Konovalova

Ivanov

Zyul'kina

et al. 2022

jour

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Introduction. Chronic forms of inflammatory periodontal diseases, leading to deterioration of bone tissue quality and volume, are the most important and urgent problems for modern dentistry. Despite the measures taken at different levels of prevention the tendency to the increase of patients with periodontitis has been revealed. The aim of the investigation was to make a comparative clinical and radiological evaluation of the effectiveness of directed tissue regeneration (DTR) using different methods of membrane placement in the area of defects with complex configuration in patients with moderate-to-severe chronic periodontitis. Material and methods. Patients were divided into two groups of 30 patients each. Study design: open randomized. Patients of the first group were operated on using DTR technique and additional membrane fixation by means of periodontal micropins; patients of the second group were operated on using DTR without additional membrane fixation. The results were assessed by clinical and radiological examination after 1, 3, 6 and 12 months. Results. More active regenerative processes were registered in the first group; the periodontal pocket depth after one month was 2,77 ± 0,08 mm, in patients of the second group – 2,85 ± 0,03 mm (p < 0,05); the tendency for decrease of this index remained during all investigation. The Hounsfield index after 12 months was 1658 ± 45.38 units in the first group and 1589 ± 12.02 units in the second group (p < 0.05). Discussion. When comparing the obtained data with those of their foreign colleagues, the authors concluded that additional fixation of the membrane leads to a less pronounced deformation and preservation of the bone volume in the long-term postoperative period. Conclusion. The use of micropins for membrane fixation allows to work with defects of complex configuration and in the long term leads to formation of denser bone tissue with preservation of its volume.

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Biocompatibility evaluation of a new bioresorbable pin for membrane fixation

Cited by 5 publications

References 19 publications

Alveolar bone repair with strontium- containing nanostructured carbonated hydroxyapatite

Alveolar bone repair with strontium- containing nanostructured carbonated hydroxyapatite

Biocompatibility Analyses of HF-Passivated Magnesium Screws for Guided Bone Regeneration (GBR)

Analysis of wound discharge microbiota in patients with drug-associated osteonecrosis of the jaw

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