Effect of sodium selenite on bone repair in tibiae of irradiated rats

Rocha, Anna Silvia Setti da; Ramos‐Perez, Flávia Maria de Moraes; Bóscolo, Frab Norberto; Manzi, Flávio Ricardo; Cchicarelo, Mariliani; Almeida, Solange María de

doi:10.1590/s0103-64402009000300002

Cited by 9 publications

(13 citation statements)

References 16 publications

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“…This difference was not observed in the measurements of the mandibular teeth, once again demonstrating that sodium selenite did not have a radioprotective action. This finding is in agreement with the study by Rocha et al (6), in which sodium selenite was not an effective radioprotector at 7 and 14 days of evaluation in bone tissue, but it is contrary to the outcomes of different studies (7,8,16,(18)(19)(20)(21).…”

Section: Discussionsupporting

confidence: 92%

“…Selenium is an essential nutrient for many species of animals, including humans (14). It is also a constituent of the peroxidase glutathione enzyme (6)(7), and this may be the explanation for its radioprotective effect. Selenium deficiency leads to a reduction in glutathione peroxidase activity (15) because it is considered an essential component of this enzyme.…”

Section: Discussionmentioning

confidence: 99%

“…Antioxidant substances have been used to minimize the damage caused by radiation in healthy tissues. Among the existing radioprotectors, selenium acts on the peroxidase glutathione enzyme (6,7), reducing the peroxides in the tissue by causing their destruction (8). The aim of this study was to evaluate the effect of sodium selenite on the development of the molars of offspring of rats irradiated during odontogenesis.…”

Section: Introductionmentioning

confidence: 99%

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Radioprotective Effect of Sodium Selenite on Developing Teeth

et al. 2013

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Radioprotective agents like selenium are used to reduce the damage caused by radiation in healthy tissues. The aim of this study was to evaluate the effect of sodium selenite on the development of the molars of offspring of rats irradiated during odontogenesis. Twenty pregnant rats were randomly divided into 4 groups: control, irradiated, selenium and selenium/irradiated. The selenium and selenium/irradiated groups received 0.3 mg/kg of sodium selenite at 18 days of pregnancy. The rats of the irradiated and selenium/irradiated groups received a single dose of 4 Gy of X rays on the abdominal region at the 19th day of pregnancy. The offspring was sacrificed at 3 and 4 days after birth for evaluation of the birefringence of the enamel organic matrix, and at 30 days for evaluation of the intercuspal dimensions of the molars. The selenium/irradiated group was similar to the irradiated group with respect to the thickness and irregularity of the enamel organic matrix region in the evaluated birefringence, as the intercuspal dimensions of the molars. In conclusion, sodium selenite had no radioprotective action on the development of the molars of offspring of rats irradiated during odontogenesis and had a toxic effect in the initial time.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Radioprotective Effect of Sodium Selenite on Developing Teeth

et al. 2013

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“…In search to reduce bone damage due to irradiation, Rocha et al (8) and Freitas et al (9) observed a radioprotective effect of sodium selenite on bone healing in rat tibia, and Felice et al (11) noted radioprotective effects of amifostine on bone strength in rat mandible. However, in this study as in others (5-7), was chosen to evaluate the NSAID meloxicam as a radiationprotective agent.…”

Section: Discussionmentioning

confidence: 99%

“…In order to mitigate oral complications, many radiationprotective agents have been studied with the aim of reducing the side effects due to radiotherapy on normal cells (5)(6)(7)(8)(9)(10)(11). Possible radioprotective effects of non-steroidal anti-inflammatory drugs (NSAIDs) have been researched recently and positive results have been observed (5,6,10).…”

Section: Introductionmentioning

confidence: 99%

Meloxicam as a Radiation-Protective Agent on Mandibles of Irradiated Rats

et al. 2017

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This study evaluated the action of ionizing radiation and the possible radioprotective effect of the non-steroidal anti-inflammatory drug meloxicam on the bone physiology of rat mandibles by assessing the alveolar socket healing and bone strength. Forty male Wistar rats were divided in 4 groups (n=10): control (CG), irradiated (IG), meloxicam (MG), meloxicam irradiated (MIG). A dose of 0.2 mg/kg meloxicam was administered to MG and MIG. After this, IG and MIG were irradiated with 15 Gy radiation dose in the mandible. Forty days after the above procedures, the mandibular first molars were extracted and the animals were killed after 15 or 30 days (n=5). Micro-computed tomography and bending test were used to evaluate alveolar socket healing and bone strength, respectively. At 15 days, bone volume, bone volume fraction and trabecular thickness were higher in the CG and MG than in the IG and MIG; and trabecular separation was higher in the IG compared with the others. At 30 days, there was a difference only in trabecular separation, which was higher in IG than in CG and MG, and MIG did not differ from the others. Bone strength was lower in IG compared with CG and MG, and MIG did not differ from the others. In conclusion, the ionizing radiation affected the bone physiology of rat mandibles, delaying the alveolar socket healing and reducing the bone strength. Moreover, the meloxicam had a positive effect on the trabecular separation in alveolar socket healing and on the bone strength.

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Preventive Effects of Supplemental Selenium and Selenium Plus Iodine on Bone and Cartilage Development in Rats Fed with Diet from Kashin–Beck Disease Endemic Area

Yao

Pei

et al. 2011

Biol Trace Elem Res

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The purpose of this study was to investigate the effects of supplemental selenium and selenium plus iodine on bone and growth plate cartilage histology and serum biochemistic parameters in rats. Ninety-six Wistar rats were randomly divided into the following four groups: group A, the rats fed with normal diet; group B, fed with diet from Kashin-Beck disease (KBD) endemic area; group C, fed with diet from KBD endemic area supplemented with selenium; and group D, fed with diet from KBD endemic area supplemented with selenium and iodine. After 4, 8, and 12 weeks, bone and cartilage samples were collected from the rats and were examined for morphological changes in the tibial growth zone and for changes in the plate cartilage and metaphysic. Compared to the rats fed with diet from the KBD endemic area, the rats fed with the supplemental selenium or selenium plus iodine exhibited diminished necrosis of the chondrocytes in the growth plate. In the groups of rats receiving supplemental selenium and selenium plus iodine, the bone volume/tissue volume ratio (BV/TV), the trabecular thickness (Tb.Th), and the trabecular number were increased, while the trabecular separation was decreased. In the 12th week of the experiment, BV/TV and Tb.Th were significantly increased in the selenium plus iodine group compared to the selenium group. It is concluded that feeding the diet from the KBD endemic area caused necrosis of chondrocytes and dysfunctions of bone development similar to the pathological changes that are seen in KBD. Selenium and iodine protected chondrocytes in growth plate and promoted the formation of trabecular bone. The effects of selenium plus iodine on bone formation were more obvious than those of selenium alone.

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Effect of sodium selenite on bone repair in tibiae of irradiated rats

Cited by 9 publications

References 16 publications

Radioprotective Effect of Sodium Selenite on Developing Teeth

Radioprotective Effect of Sodium Selenite on Developing Teeth

Meloxicam as a Radiation-Protective Agent on Mandibles of Irradiated Rats

Preventive Effects of Supplemental Selenium and Selenium Plus Iodine on Bone and Cartilage Development in Rats Fed with Diet from Kashin–Beck Disease Endemic Area

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