Bone response to a Ca- and P-enriched titanium surface obtained by anodization

Abstract

This study evaluated bone response to a Ca-and P-enriched titanium (Ti) surface treated by a multiphase anodic spark deposition coating (BSP-AK). Two mongrel dogs received bilateral implantation of 3 Ti cylinders (4.1 x 12 mm) in the humerus, being either BSP-AK treated or untreated (machined -control). At 8 weeks postimplantation, bone fragments containing the implants were harvested and processed for histologic and histomorphometric analyses. Bone formation was observed in cortical area and towards the medullary canal associated to approximately 1/3 of implant extension. In most cases, in the medullary area, collagen fiber bundles were detected adjacent and oriented parallel to Ti surfaces. Such connective tissue formation exhibited focal areas of mineralized matrix lined by active osteoblasts. The mean percentages of bone-to-implant contact were 2.3 (0.0-7.2 range) for BSP-AK and 0.4 (0.0-1.3 range) for control. Although the Mann-Whitney test did not detect statistically significant differences between groups, these results indicate a trend of BSP-AK treated surfaces to support contact osteogenesis in an experimental model that produces low bone-to-implant contact values.

The effect of different surgical drilling procedures on full laser‐etched microgrooves surface‐treated implants: an experimental study in sheep

“…; Franco Rde et al. ). Hydrophilic surfaces have also been introduced to optimize cell–material interactions due to the high surface energy created by the sandblasting or oxidation (Buser et al.…”

Bone tissue, cellular, and molecular responses to titanium implants treated by anodic spark deposition

“…Indeed, BIC was higher on AE surfaces irrespective of the evaluation period. Previously, we did not observe significant differences in terms of BIC by comparing ASD‐AK and machined Ti cylinders implanted into dog humeri 10. Additionally, it has been reported that surfaces treated by ASD elicit a positive effect on bone formation compared to nontreated surfaces when Ti cylinders or screw‐thread fixtures are implanted into long bones of sheep and rabbit 7, 18, 19.…”

“…The performance of ASD‐AK surfaces has been extensively evaluated by using in vitro and in vivo models and overall, promising outcomes have been reported 7–11. These previous in vitro studies were carried out using immortalized or primary osteoblasts cultured directly on ASD‐AK surfaces and in vivo evaluations were achieved by placing Ti implants into animal (sheep, rabbit, and dog) long bones.…”

Improving osseointegration of dental implants

“…Several techniques to modify the implant surface have been proposed to improve the success rate of oral rehabilitation with osseointegrated implants [13,38,49,[76][77][78][79][80][81][82][83][84][85][86]. The results provide guidelines for the development of implant surfaces.…”