A randomized double-blinded trial of chloral hydrate with or without hydroxyzine versus placebo for pediatric dental sedation

Costa, Luciane Rezende; Costa, Paulo Sucasas; Lima, Alessandra Rodrigues de Almeida

doi:10.1590/s0103-64402007000400012

Cited by 31 publications

(13 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Chloral hydrate is another safe and effective sedative drug, but it does not appear to have any advantages over midazolam (28,30). A combination of chloral hydrate and hydroxyzine only results in more side effects, and therefore this combination should not be administered to patients (28).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Current methods of sedation in dental patients - a systematic review of the literature

Corcuera-Flores¹,

Silvestre‐Rangil²,

Cutando-Soriano³

et al. 2016

Med Oral

View full text Add to dashboard Cite

ObjetiveThe main objective of this systematic literature review is to identify the safest and most effective sedative drugs so as to ensure successful sedation with as few complications as possible.Study DesignA systematic literature review of the PubMed MEDLINE database was carried out using the key words “conscious sedation,” “drugs,” and “dentistry.” A total of 1,827 scientific articles were found, and these were narrowed down to 473 articles after applying inclusion and exclusion criteria. These 473 studies were then individually assessed for their suitability for inclusion in this literature review.ResultsA total of 21 studies were selected due to their rigorous study design and conduciveness to further, more exhaustive analysis. The selected studies included a total of 1,0003 patients classified as ASA I or II. Midazolam was the drug most frequently used for successful sedation in dental surgical procedures. Ketamine also proved very useful when administered intranasally, although some side effects were observed when delivered via other routes of administration. Both propofol and nitrous oxide (N2O) are also effective sedative drugs.ConclusionsMidazolam is the drug most commonly used to induce moderate sedation in dental surgical procedures, and it is also very safe. Other sedative drugs like ketamine, dexmedetomidine and propofol have also been proven safe and effective; however, further comparative clinical studies are needed to better demonstrate which of these are the safest and most effective. Key words:Conscious sedation, drugs, dentistry.

show abstract

Section: Discussionmentioning

confidence: 99%

“…A combination of chloral hydrate and hydroxyzine only results in more side effects, and therefore this combination should not be administered to patients (28). Triclofos was shown to have a less powerful sedative effect than midazolam (25).…”

Section: Discussionmentioning

confidence: 99%

Current methods of sedation in dental patients - a systematic review of the literature

Corcuera-Flores¹,

Silvestre‐Rangil²,

Cutando-Soriano³

et al. 2016

Med Oral

View full text Add to dashboard Cite

show abstract

“…Chloral hydrate, [14][15][16][17] has long enjoyed great popularity in the pharmacological management of the pediatric dental patients, is usually administered orally or rectally in a dosage of 25 to 75 mg/kg body weight. 18 One of the main attributes of drug is its minimal effect on respiration, though respiratory depression 19,20 and deaths have also been reported.…”

Section: Chloral Hydratementioning

confidence: 99%

Pediatric Dental Sedation Practice: Evolution and Current State-of-the-Art

Mittal¹

2014

Journal of Postgraduate Medicine, Education and Research

View full text Add to dashboard Cite

The practice of the pediatric dental sedation has evolved conti nuously during the past few decades. Newer agents continuously seem to replace older agents and the pediatric dentists need to update themselves timely to efficiently administer sedation to their young and anxious patients. The practice and the research of pediatric dental sedation is very diverse throughout the world. In this paper, we attempt to review the diversity of pediatric dental sedation research through a systematic review. Further, we review the pharmacopoeia of pediatric dental sedation with brief description of commonly used agents. We also touch upon evolution of pediatric dental sedation guidelines in different countries and international variation in pediatric dental sedation practice. Lastly, we review the future perspective of research pertaining to field of pediatric dental sedation research.

show abstract

“…NESO is run by a multi-professional team, involving pediatric dentists, dentists from other specialties, pediatricians, anesthesiologists, psychologists, oral therapists, that follow most of the AAPD, AAP and ASA guidelines for outpatient sedation. Several protocols have been investigated in NESO, and in 2007 members of the NESO team published the book (in Portuguese): "Sedation in dentistry: Demythologizing its practice" [ 244 ]. Today NESO recommends oral midazolam with or without ketamine for pediatric dental sedation, which are provided by the anesthesiologist.…”

Section: What Sedation Regimens Are Being Used And/or Investigated Inmentioning

confidence: 99%

Sedation of Pediatric Patients for Dental Procedures: The United States, European, and South American Experience

Wilson

Hosey

Costa

2014

Pediatric Sedation Outside of the Operating Room

View full text Add to dashboard Cite

The challenges of sedating a child for dental procedures are multifactorial: The patient's age, health, temperament and emotional status, parental concerns, clinician philosophy on patient management, extent and quality of clinician training and experiences with sedation, state dental board regulation of sedation, issues of third-party coverage or parental reimbursement, knowledge of and adherence by clinicians to sedation guidelines, facility preparedness, and support staff experiences are but a few of many important considerations. To overcome these challenges, a pediatric dentist has to be at the hub of the preventive, operative and behavioral treatment plan.The fi rst section of this chapter is devoted to sedation practices performed primarily in the United States. The second section of this chapter describes sedation practices associated with the United Kingdom and Europe. The closing section will provide an overview of the state of sedation for pediatric dental procedures in South America, as an example of different solutions to sedation management in underdeveloped/developing countries.

show abstract

A randomized double-blinded trial of chloral hydrate with or without hydroxyzine versus placebo for pediatric dental sedation

Cited by 31 publications

References 3 publications

Current methods of sedation in dental patients - a systematic review of the literature

Current methods of sedation in dental patients - a systematic review of the literature

Pediatric Dental Sedation Practice: Evolution and Current State-of-the-Art

Sedation of Pediatric Patients for Dental Procedures: The United States, European, and South American Experience

Contact Info

Product

Resources

About