Uso de biomarcadores na sepse: muitas perguntas, poucas respostas

Póvoa, Pedro; Salluh, Jorge I.

doi:10.1590/s0103-507x2013000100001

Cited by 7 publications

(3 citation statements)

References 16 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(18-20) Considering that CRP measurements have already been extensively used in clinical practice for many years and that they can be obtained with easy access and low cost and are available in most healthcare facilities, CRP is confirmed as a key biomarker of response to antibiotic treatment when analyzed dynamically. This type of analysis thus deserves a similar evaluation in pediatric patients; such evaluation has already been reported, albeit preliminarily.…”

Section: Introductionmentioning

confidence: 99%

Use of biomarkers in pediatric sepsis: literature review

Lanziotti

Póvoa

Soares

et al. 2016

Revista Brasileira De Terapia Intensiva

Self Cite

View full text Add to dashboard Cite

Despite advances in recent years, sepsis is still a leading cause of hospitalization and mortality in infants and children. The presence of biomarkers during the response to an infectious insult makes it possible to use such biomarkers in screening, diagnosis, prognosis (risk stratification), monitoring of therapeutic response, and rational use of antibiotics (for example, the determination of adequate treatment length). Studies of biomarkers in sepsis in children are still relatively scarce. This review addresses the use of biomarkers in sepsis in pediatric patients with emphasis on C-reactive protein, procalcitonin, interleukins 6, 8, and 18, human neutrophil gelatinase, and proadrenomedullin. Assessment of these biomarkers may be useful in the management of pediatric sepsis.

show abstract

Section: Introductionmentioning

confidence: 99%

Use of biomarkers in pediatric sepsis: literature review

Lanziotti

Póvoa

Soares

et al. 2016

Revista Brasileira De Terapia Intensiva

Self Cite

View full text Add to dashboard Cite

show abstract

“…CRP concentrations have been extensively used and correlate with ongoing organ dysfunction, ICU mortality and likely also with bacterial burden. (31-33) This marker is routinely measured in the ICU and has advantages of simplicity, reproducibility and speed. (31,34)…”

Section: Discussionmentioning

confidence: 99%

suPAR in the assessment of post intensive care unit prognosis: a pilot study

Silvestre

Coelho

Pereira

et al. 2018

Revista Brasileira De Terapia Intensiva

Self Cite

View full text Add to dashboard Cite

ObjectiveTo determine the performance of soluble urokinase-type plasminogen activator receptor upon intensive care unit discharge to predict post intensive care unit mortality.MethodsA prospective observational cohort study was conducted during a 24-month period in an 8-bed polyvalent intensive care unit. APACHE II, SOFA, C-reactive protein, white cell count and soluble urokinase-type plasminogen activator receptor on the day of intensive care unit discharge were collected from patients who survived intensive care unit admission.ResultsTwo hundred and two patients were included in this study, 29 patients (18.6%) of whom died after intensive care unit discharge. Nonsurvivors were older and more seriously ill upon intensive care unit admission with higher severity scores, and nonsurvivors required extended use of vasopressors than did survivors. The area under the receiver operating characteristics curves of SOFA, APACHE II, C-reactive protein, white cell count, and soluble urokinase-type plasminogen activator receptor at intensive care unit discharge as prognostic markers of hospital death were 0.78 (95%CI 0.70 - 0.86); 0.70 (95%CI 0.61 - 0.79); 0.54 (95%CI 0.42 - 0.65); 0.48 (95%CI 0.36 - 0.58); and 0.68 (95%CI 0.58 - 0.78), respectively. SOFA was independently associated with a higher risk of in-hospital mortality (OR 1.673; 95%CI 1.252 - 2.234), 28-day mortality (OR 1.861; 95%CI 1.856 - 2.555) and 90-day mortality (OR 1.584; 95%CI 1.241 - 2.022).ConclusionAt intensive care unit discharge, soluble urokinase-type plasminogen activator receptor is a poor predictor of post intensive care unit prognosis.

show abstract

“…Then the qualification step will allow the evaluation of the evidence that demonstrates an association between the biomarker(s) and the disease. Finally, the last step is the evaluation of the clinical use of biomarker(s) [ 102 ].…”

Section: Main Biomarkers Of Equine Sepsis: a Proof Of Concept For Hum...mentioning

confidence: 99%

Spontaneous Sepsis in Adult Horses: From Veterinary to Human Medicine Perspectives

Blangy-Letheule

Vergnaud

Dupas

et al. 2023

Cells

View full text Add to dashboard Cite

Sepsis is a life-threatening disease defined as an organ dysfunction caused by a dysregulated host response to an infection. Early diagnosis and prognosis of sepsis are necessary for specific and timely treatment. However, no predictive biomarkers or therapeutic targets are available yet, mainly due to the lack of a pertinent model. A better understanding of the pathophysiological mechanisms associated with sepsis will allow for earlier and more appropriate management. For this purpose, experimental models of sepsis have been set up to decipher the progression and pathophysiology of human sepsis but also to identify new biomarkers or therapeutic targets. These experimental models, although imperfect, have mostly been performed on a murine model. However, due to the different pathophysiology of the species, the results obtained in these studies are difficult to transpose to humans. This underlines the importance of identifying pertinent situations to improve patient care. As humans, horses have the predisposition to develop sepsis spontaneously and may be a promising model for spontaneous sepsis. This review proposes to give first an overview of the different animal species used to model human sepsis, and, secondly, to focus on adult equine sepsis as a spontaneous model of sepsis and its potential implications for human and veterinary medicine.

show abstract

Uso de biomarcadores na sepse: muitas perguntas, poucas respostas

Cited by 7 publications

References 16 publications

Use of biomarkers in pediatric sepsis: literature review

Use of biomarkers in pediatric sepsis: literature review

suPAR in the assessment of post intensive care unit prognosis: a pilot study

Spontaneous Sepsis in Adult Horses: From Veterinary to Human Medicine Perspectives

Contact Info

Product

Resources

About