Associação entre a evolução da disfunção orgânica e as concentrações de citocinas na fase inicial do choque séptico

Abstract

Objective: To investigate the correlation of organ dysfunction and its progression with inflammatory response during the early phases of septic shock by assessing baseline cytokine concentrations.Methods: This study included patients over 18 years old with septic shock within the first 48 hours after the onset of organ dysfunction. Interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10) and C-reactive protein levels were assessed at inclusion and after 24 hours, and the differences between these values were calculated. The progression of organ dysfunction was assessed using the Sequential Organ Failure Assessment (SOFA) score upon admission and 24 hours later for a delta-SOFA determination and were categorized as either worsened or improved. The results were expressed as means + standard deviation or median (25-75% percentiles). Values with descriptive p values of 0.05 or less were considered significant.

Protein from Hevea brasiliensis “Hev b 13” latex attenuates systemic inflammatory response and lung lesions in rats with sepsis

“…This imbalance in cytokine production causes endothelial lesions, pulmonary edema and hemorrhage, and may evolve to terminal complications associated with sepsis (MODS) (Zhou et al, 2015). The association between higher concentrations of pro-inflammatory cytokines in the acute phase of sepsis and the unfavorable evolution of organic dysfunctions have been studied and confirmed (Chien et al, 2011;Machado et al, 2011;Saad et al, 2016). Interfering in the excessive production of these mediators during the acute phase of sepsis, as occurred in our study, may result in better prognosis of the disease.…”

Aplicabilidade do índice SOFA em pacientes com sepse em uma Unidade de Terapia Intensiva de um Hospital na cidade de Fortaleza/CE

“…Por esse e outros motivos a coleta diária deve ser seguida. 19 Neste estudo, o SOFA foi associado à mortalidade, mostrando que quanto mais grave for a forma de apresentação inicial da doença, tanto maior a mortalidade, revelan-Hassan Kelvin Feitosa Evangelista et al do uma maior probabilidade de idosos irem a óbito. Confirmando o conceito atual de que a sepse é uma doença dependente do tempo.…”

Immunomodulating Effects of the Purified Hev B 13 Fraction on Septic Rats

“…Its clinical manifestations - such as fever, edema, hypercoagulation, tachypnea and peripheral hypotension - derive from the systemic release of inflammatory mediators, called cytokines, by the defense and endothelial cells, playing an important role acting as chemical messengers 2 , 3 . There are still those who characterize sepsis as the rupture of the complex balance between pro-inflammatory and anti-inflammatory cytokines 10 .…”

“…The imbalance between these mediators is strongly related to severity and mortality in sepsis, which mainly in the acute phase of the disease produces exacerbated pro-inflammatory cytokines contributing to target organ damage, leading to multiple organ failure and death. The association between high concentrations of proinflammatory cytokines IL-1, IL-6 and TNF in the acute phase of sepsis and severe organ dysfunctions has been studied and proven 5 , 10 , 13 .…”