Suplementação de antioxidantes no tratamento da lesão pulmonar aguda: meta-análise

Galvão, André Martins; Andrade, Arméle Dornelas de; Maia, Maria Bernadete de Souza; Silva, Keyla Emanuelle Ramos da; Bezerra, Alice de Andrade; Melo, Jorge Dantas de; Morais, Natália Gomes de; Costa, Thacianna Barreto da; Castro, Célia Maria Machado Barbosa de

doi:10.1590/s0103-507x2011000100008

Cited by 9 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this scenario, dietary antioxidants may play an important role against lung oxidative stress [77]. Several studies reported the protective role of the antioxidants in lung infection and in lung inflammation [78,79].…”

Section: Other Dietary Constituents and Lung Infectionsmentioning

confidence: 99%

Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work

Messina

Polito

Monda

et al. 2020

IJMS

150

141

View full text Add to dashboard Cite

Background: On the 31 December 2019, the World Health Organization (WHO) was informed of a cluster of cases of pneumonia of unknown origin detected in Wuhan City, Hubei Province, China. The infection spread first in China and then in the rest of the world, and on the 11th of March, the WHO declared that COVID-19 was a pandemic. Taking into consideration the mortality rate of COVID-19, about 5-7%, and the percentage of positive patients admitted to intensive care units being 9-11%, it should be mandatory to consider and take all necessary measures to contain the COVID-19 infection. Moreover, given the recent evidence in different hospitals suggesting IL-6 and TNF-α inhibitor drugs as a possible therapy for COVID-19, we aimed to highlight that a dietary intervention could be useful to prevent the infection and/or to ameliorate the outcomes during therapy. Considering that the COVID-19 infection can generate a mild or highly acute respiratory syndrome with a consequent release of pro-inflammatory cytokines, including IL-6 and TNF-α, a dietary regimen modification in order to improve the levels of adiponectin could be very useful both to prevent the infection and to take care of patients, improving their outcomes.

show abstract

Section: Other Dietary Constituents and Lung Infectionsmentioning

confidence: 99%

Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work

Messina

Polito

Monda

et al. 2020

IJMS

150

141

View full text Add to dashboard Cite

show abstract

“…Many natural compounds have been used for centuries in the Asian subcontinent with limited toxicity, and they showed multiple effects like activating the mechanisms of antioxidant defense in addition to inhibiting pro-inflammatory signaling. However, it is crucial to conduct human experiments to examine the pharmacokinetics and pharmacodynamics of these compounds before using them as a treatment [71,76] (Table 1). In the present review study, the use of several antioxidants combination will be described below that may be helpful in the treatment of COVID-19.…”

Section: Treatment With Antioxidant Supplementsmentioning

confidence: 99%

A Promising Approach to Improving COVID-19 Symptoms: Using Antioxidant Supplements

Shahbaz

Naderi

Hedayati

et al. 2021

The Journal of Qazvin University of Medical Sciences

View full text Add to dashboard Cite

Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) that causes COVID-19 could progress to acute respiratory distress syndrome (ARDS). The immune cells' migration in response to virus lead to cell death by releasing oxidizing free radicals. These oxidizing free radicals mediate NF-κB activation and induce transcription of cytokine-producing genes that eventually a cytokine storm ensues, leading to septic shock. The over-expression of oxidative stress and enhancing ROS and RNS production activates transcription factors like NF-κB, so repeating this cycle intensifies the host inflammatory responses. In this way, antioxidants as compounds that inhibit oxidation by terminating chain reactions are suggested for alleviating the COVID-19 demonstration. In the present review study, the pathogenesis of the virus, the virus immunopathology, the balance between immune responses and oxidative stress are discussed. Also in this review, due to the importance of oxidative stress in the pathogenesis of the disease, some of the most important antioxidant agents whose therapeutic effects have been shown in improving many viral infections, ARDS, and acute lung injury, are recommended to improve the patient’s condition infected with SARS-CoV-2. Besides, the last COVID-19 clinical studies in this field are summarized in this review article. These studies described that melatonin through promoting sleep quality by decreasing vascular permeability, reducing anxiety, and regulating blood pressure; and vitamin C through decreasing the mortality rates and the requirement for mechanical ventilation; and Glutathione through decreasing respiratory distress in the pneumonia of COVID-19 patients; and higher selenium levels could improve the COVID-19 patients' clinical outcomes

show abstract

Foods as First Defense Against COVID-19

Mahwish

Alothman

2021

Alternative Medicine Interventions for COVID-19

View full text Add to dashboard Cite

Suplementação de antioxidantes no tratamento da lesão pulmonar aguda: meta-análise

Cited by 9 publications

References 28 publications

Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work

Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work

A Promising Approach to Improving COVID-19 Symptoms: Using Antioxidant Supplements

Foods as First Defense Against COVID-19

Contact Info

Product

Resources

About