Como realizar ensaios clínicos em terapia intensiva utilizando base de dados de alta qualidade

Français, Adrien; Vesin, Aurélien; Timsit, Jean‐François

doi:10.1590/s0103-507x2008000300013

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…We conducted an observational study on a prospective multicenter database (OutcomeRea; www.outcomerea.org) fed by 22 French ICUs between April 1999 and January 2014. Details about the database and its quality have already been described [5–8].…”

Section: Methodsmentioning

confidence: 99%

Influence of dyskalemia at admission and early dyskalemia correction on survival and cardiac events of critically ill patients

Bouadma¹,

Mankikian²,

Darmon³

et al. 2019

Crit Care

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ObjectivesOur objectives were (1) to characterize the distribution of serum potassium levels at ICU admission, (2) to examine the relationship between dyskalemia at ICU admission and occurrence of cardiac events, and (3) to study both the association between dyskalemia at ICU admission and dyskalemia correction by day 2 on 28-day mortality.DesignInception cohort study from the longitudinal prospective French multicenter OUTCOMEREA database (1999–2014)Setting22 French OUTCOMEREA network ICUsPatientsPatients were classified into six groups according to their serum potassium level at admission: three groups of hypokalemia and three groups of hyperkalemia defined as serious hypokalemia [K+] < 2.5 and serious hyperkalemia [K+] > 7 mmol/L, moderate hypokalemia 2.5 ≤ [K+] < 3 mmol/L and moderate hyperkalemia 6 < [K+] ≤ 7 mmol/L, and mild hypokalemia 3 ≤ [K+] < 3.5 mmol/L and mild hyperkalemia 5 < [K+] ≤ 6 mmol/L. We sorted evolution at day 2 of dyskalemia into three categories: balanced, not-balanced, and overbalanced.InterventionNoneMeasurements and main resultsOf 12,090 patients, 2108 (17.4%) had hypokalemia and 1445 (12%) had hyperkalemia.Prognostic impact of dyskalemia and its correction was assessed using multivariate Cox models. After adjustment, hypokalemia and hyperkalemia were independently associated with a greater risk of 28-day mortality. Mild hyperkalemic patients had the highest mortality (hazard ratio (HR) 1.29, 95% confidence interval (CI) [1.13–1.47], p < 0.001). Adjusted 28-day mortality was higher if serum potassium level was not-balanced at day 2 (aHR = 1.51, 95% CI [1.30–1.76], p < 0.0001) and numerically higher but not significantly different if serum potassium level was overbalanced at day 2 (aHR = 1.157, 95% CI [0.84–1.60], p = 0.38). Occurrence of cardiac events was evaluated by logistic regression. Except for patients with serious hypokalemia at admission, the depth of dyskalemia was associated with increased risk of cardiac events.ConclusionsDyskalemia is common at ICU admission and associated with increased mortality. Occurrence of cardiac events increased with dyskalemia depth. A correction of serum potassium level by day 2 was associated with improved prognosis.

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Section: Methodsmentioning

confidence: 99%

Influence of dyskalemia at admission and early dyskalemia correction on survival and cardiac events of critically ill patients

Bouadma¹,

Mankikian²,

Darmon³

et al. 2019

Crit Care

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Proposed computerized protocol for epidemiological study of patients undergoing microsurgery of the larynx

Catani¹,

Carvalho²,

Filho³

et al. 2012

Int Arch Otorhinolaryngol

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Summary Introduction: The merging of medicine with information technology facilitates the retrieval of stored data, aiding the conduct of research with greater scientific rigor. Studies in the field of otorhinolaryngology, specifically in the area of laryngology and voice, are of fundamental importance, since 70% of the economically active need their voice to work. Objective: To create a computerized protocol of the diseases of the larynx, apply and validate it, and use it to evaluate patients undergoing laryngoscopic microsurgery of the larynx. Method: We created a database of ENT diseases through a literature review of textbooks and scientific articles. Next, we computerized the data and incorporated it into the SINPE©, creating a master protocol (ENT diseases) and a specific protocol (laryngeal diseases). Data were collected prospectively from patients undergoing laryngeal microsurgery in the ENT Hospital of Paraná. The collected data were analyzed with graphs through the SINPE© Analyzer module. Results: We evaluated 245 patients aged 9–79 years, and determined that 36.61% (93 patients) underwent surgery for the presence of polyps on the vocal folds, 12.6% (32) underwent surgery for papillomatosis, and 11.83% (29) underwent surgery for intracordal cysts. Conclusions: The creation of an electronic database of clinical ENT diseases was feasible. We were also able to implement and validate the protocol. The database may be released to physicians involved in clinical data collection and retrieval of information to conduct scientific research in an organized manner. The most common laryngeal disorders identified were polyps, papilloma, and intracordal cysts.

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Como realizar ensaios clínicos em terapia intensiva utilizando base de dados de alta qualidade

Cited by 2 publications

References 29 publications

Influence of dyskalemia at admission and early dyskalemia correction on survival and cardiac events of critically ill patients

Influence of dyskalemia at admission and early dyskalemia correction on survival and cardiac events of critically ill patients

Proposed computerized protocol for epidemiological study of patients undergoing microsurgery of the larynx

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