O uso da drotrecogina alfa ativada na prática clínica e as atuais evidências

Abstract

SUMMARY BACKGROUND AND OBJECTIVES:The debate on effi cacy and patient safety related to the use of drotrecogin alfa (DrotAA) is timely, principally due to the negative results observed in clinical studies performed after the PROWESS study, and the economic costrelated impact of the drug on the healthcare system. The aim of this study was to review the main studies on the use of DrotAA in patients with severe sepsis.