Clonidina associada à morfina e midazolam em crianças submetidas à ventilação mecânica: estudo aleatório, duplamente encoberto e placebo controlado

Clonidine for sedation in the critically ill: a systematic review and meta-analysis

“…After excluding a further 25 studies, a total of eight RCTs met inclusion criteria [24–31]. In addition, we identified three ongoing RCTs (NCT01139996, NCT02509273, NCT01876355) (Fig.…”

“…Four trials enrolled children [24–26, 29] and four enrolled adults [27, 28, 30, 31]. Clonidine was administered intravenously in six trials [24, 26–30] and via the enteral route in two trials [25, 31]. The trials that used intravenous clonidine took place in Brazil, the United Kingdom, Germany, India and Italy [24, 26–30], respectively.…”

“…Clonidine was administered intravenously in six trials [24, 26–30] and via the enteral route in two trials [25, 31]. The trials that used intravenous clonidine took place in Brazil, the United Kingdom, Germany, India and Italy [24, 26–30], respectively. The doses of clonidine varied considerably, with enteral clonidine doses ranging from 0.1 to 0.2 mg every 8 hours [31] to 5 μg/kg every 6 hours [25].…”

“…The doses for IV continuous clonidine infusions ranged from 0.88 to 3 μg/kg/hour [26–30] and some studies used an initial bolus dose [26, 28, 30]. One study used intermittent IV doses of clonidine at 5 μg/kg every 8 hours [24]. Most trials used clonidine as an adjunctive agent added to an established sedative regimen, generally consisting of a benzodiazepine and/or an opioid [24–26, 29–31].…”

“…One study used intermittent IV doses of clonidine at 5 μg/kg every 8 hours [24]. Most trials used clonidine as an adjunctive agent added to an established sedative regimen, generally consisting of a benzodiazepine and/or an opioid [24–26, 29–31]. A single trial used clonidine as a stand-alone agent, compared to dexmedetomidine [27].…”