Biological and structure-activity evaluation of chalcone derivatives against bacteria and fungi

Abstract

O presente trabalho descreve as atividades antibacterianas e antifúngicas de diversas chalconas obtidas diretamente através da condensação aldólica tipo Claisen-Schmidt das quais se determinou a concentração inibitória mínima frente a diferentes microrganismos (bactérias Gram-positivas e Gram-negativas e fungos). Estruturas no estado sólido cristalino de sete chalconas foram determinadas por análise de difração de raios X (XRD). Estudos quimiométricos foram realizados com intuito de identificar uma potencial relação entre estrutura e atividade.The present work describes the antibacterial and antifungal activities of several chalcones obtained by a straight Claisen-Schmidt aldol condensation determined by the minimal inhibitory concentration against different microorganisms (Gram-positive and Gram-negative bacteria and fungi). Solid state crystal structures of seven chalcones were determined by X-ray diffraction (XRD) analysis. Chemometric studies were carried out in order to identify a potential structureactivity relationship.

Antimicrobial Activity of Xanthohumol and Its Selected Structural Analogues

“…Additionally, we tested a group of eight 4 1 -methoxychalcones 8-15, differing in the electronegativity of the substituents at C-4. The minimal concentration that inhibits growth of a microorganism (MIC) for 4 1 -methoxychalcone 15, known from the literature, determined towards ten different microorganisms was equal or more than 100 µg/mL [19]. For our tests we decided to use the disc diffusion method and to add to the group of microorganisms described in that work two strains that were not tested: Alternaria sp.…”

Pólen apícola desidratado: composição físico-química, qualidade microbiologica, compostos fenólicos e flavonoides, capacidade antioxidante e origem botânica

“…são: acila, C-metlia, metileno, dioxila, isopreno, pirano, furano e seus derivados clorados (SIMÕES et al, 2004, DORNAS et al, 2007. (DYRAGER et al, 2011, SILVA et al, 2013.…”

The Influence of Methoxy and Ethoxy Groups on Supramolecular Arrangement of Two Methoxy-chalcones

“…[1][2][3][4][5][6][7][8][9] Chemically, the molecular skeleton is characterized by aromatic rings moieties connected through three-carbon bridge having a keto carbonyl group and one α,β-unsaturation ( Figure 1). 5,[10][11][12][13] Chalcones and chalcone derivatives are often obtained from natural or synthetic sources. 8,14 By synthesis perspective, the Claisen-Schmidt condensation of aromatic aldehyde and aromatic acetophenone under either base or acid catalysis is a widely employed method to the synthesis of chalcones.…”

“…8,14 By synthesis perspective, the Claisen-Schmidt condensation of aromatic aldehyde and aromatic acetophenone under either base or acid catalysis is a widely employed method to the synthesis of chalcones. 5,[10][11][12][13] The versatility of class is evident from its wide-ranging biological activities; in particular, antiviral, anthelmintic, amoebicidal, antibacterial, antiprotozoal, antiulcer, cytotoxic, insecticidal, and anticancer. 13,[15][16][17][18] Also, due to its chemical structure, several chalcones have been reported to exhibit non-linear optical (NLO) properties that turn these compounds into potential functional materials.…”

“…5,[10][11][12][13] The versatility of class is evident from its wide-ranging biological activities; in particular, antiviral, anthelmintic, amoebicidal, antibacterial, antiprotozoal, antiulcer, cytotoxic, insecticidal, and anticancer. 13,[15][16][17][18] Also, due to its chemical structure, several chalcones have been reported to exhibit non-linear optical (NLO) properties that turn these compounds into potential functional materials. [19][20][21] A study with methoxychalcone 19 investigated the optical properties of 3,4-dimethoxy-4'-methoxychalcone and it has shown promise for nonlinear optical applications.…”