7,8-secolignans from Schisandra neglecta and their anti-HIV-1 activities

Abstract

Quatro novas 7,8-secoligninas (neglectahenols A-D), juntamente com duas 7,8-secolignanas conhecidas, foram isoladas de folhas e caules de Schisandra neglecta. As estruturas foram elucidadas por métodos espectroscópicos, incluindo a técnica de RMN (ressonância magnética nuclear) em uma e duas dimensões. As atividades anti-HIV-1 (vírus da imunodeficiência humana tipo 1) das 7,8-secoligninas e dos neglectahenols também foram testadas, e todos mostraram atividades moderadas. Four new 7,8-secolignans (neglectahenols A-D), together with two known 7,8-secolignans, were isolated from leaves and stems of Schisandra neglecta. The structures were elucidated by spectroscopic methods, including extensive one and two dimension NMR (nuclear magnetic resonance) techniques. 7,8-Secolignans and neglectahenols A-D were also tested for their anti-HIV-1 (human immunodeficiency virus type 1) activities, and all of them showed modest activities.

Lignans from the Australian Endemic Plant Austrobaileya scandens

“…The aryltetralin lignans are well-known to cause apoptosis by inducing the G2/M phase arrest, disrupt microtubules, and inhibit the enzyme topoisomerase II . However, a mode of antiproliferation of the 7,8-seco-lignans with 15 natural products found up to now ,− has not been reported. Therefore, in this study, compound 5 was chosen to further examine the mechanism of its antiproliferation.…”

Lignans from the Fruit of Schisandra glaucescens with Antioxidant and Neuroprotective Properties

“…7,8-Seco-lignans (or 1-phenylbutyl benzoates) are a group of rare lignans that possess various bioactivities, including anti-HIV, 8,9 anti-HSV, 10 antiadenovirus, 10 and cytotoxic activities. 11 These compounds were first isolated from the leaves of Ocotea foetens (Lauraceae) in 1995 12 and were then found in Holostylis reniformis (Aristolochiaceae) and Beilschmiedia tsangii (Lauraceae).…”

“…14 Since then, a number of analogues have been isolated from plants in the Schisandraceae family. [8][9][10]15 Most structural studies of 7,8-seco-lignans have focused on 7,8-seco-holostylone B. 13 One-and two-dimensional NMR experiments have been used to determine the relative configuration of 7,8-seco-holostylone B, but its absolute configuration has not been determined.…”

“…7,8-Seco-lignans (or 1-phenylbutyl benzoates) are a group of rare lignans that possess various bioactivities, including anti-HIV, , anti-HSV, antiadenovirus, and cytotoxic activities . These compounds were first isolated from the leaves of Ocotea foetens (Lauraceae) in 1995 and were then found in Holostylis reniformis (Aristolochiaceae) and Beilschmiedia tsangii (Lauraceae). , In 2009, these compounds were identified for the first time in a plant in the Schisandraceae family when two 7,8-seco-lignans were isolated from the fruit of S. sphenanthera .…”

“…These compounds were first isolated from the leaves of Ocotea foetens (Lauraceae) in 1995 and were then found in Holostylis reniformis (Aristolochiaceae) and Beilschmiedia tsangii (Lauraceae). , In 2009, these compounds were identified for the first time in a plant in the Schisandraceae family when two 7,8-seco-lignans were isolated from the fruit of S. sphenanthera . Since then, a number of analogues have been isolated from plants in the Schisandraceae family. − , …”