A new megastigmane diglycoside from Litsea glutinosa (Lour.) C. B. Rob.

Wang, Yunsong; Liao, Zhen Yuan; Li, Yan; Huang, Rong; Zhang, Hongbing; Yang, Jing‐Hua

doi:10.1590/s0103-50532011001100030

Cited by 16 publications

(13 citation statements)

References 17 publications

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“…Rob. (Wang et al, 2011). Phylogenetic analysis of Lauraceae positioned Nectandra as belonging to the Cinnamomeae clade of plants occurring mainly in South America, while Apollonias, found in Canary and Madeira Islands was positioned as part of Persea group and Litsea and Laurus belong to the ancestral clade Laureae, distributed in Asia and Mediterranean regions (Chanderbali et al, 2001).…”

Section: Chemotaxonomic Significancementioning

confidence: 99%

Chemical constituents from Nectandra cuspidata Nees – Lauraceae

Batista

Yoshida

Garcez

et al. 2015

Biochemical Systematics and Ecology

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a b s t r a c tThe phytochemical study of Nectandra cuspidata led to the isolation and characterization of the new megastigmane 7-megastigmen-3b,6b,9x-triol (1), the aporphinoid alkaloids (À)-glaziovine (2) and (þ)-apoglaziovine (3), the sesquiterpene costic acid (4), polyprenols (5, 6 and 8), a-tocopherol (7) and the steroid b-sitosterol (9). The structures of the compounds were elucidated based on spectroscopic data. This is the first description of the presence of megastigmanes in Nectandra genus. All compounds (1-9) were isolated for the first time from this species. The chemotaxonomic significance of these compounds was also summarized.

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Section: Chemotaxonomic Significancementioning

confidence: 99%

Chemical constituents from Nectandra cuspidata Nees – Lauraceae

Batista

Yoshida

Garcez

et al. 2015

Biochemical Systematics and Ecology

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“…glutinosa leaves and twigs (Wang et al, 2011). A new 2'-Oxygenated Flavone Glycoside, named Glutin was isolated from the leaf extract of L. glutinosa .…”

Section: Resultsmentioning

confidence: 99%

Litsea glutinosa (Lauraceae): Evaluation of its Foliar Phytochemical Constituents for Antimicrobial Activity

Lagudu

Owk

2018

Not Sci Biol

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The phytochemical investigation of the leaves of Litsea glutinosa revealed the presence of secondary metabolites like alkaloids, anthraquinones, cardiac glycosides, flavonoids, glycosides, phenols, saponins, steroids, tannins, terpenoids, volatile compounds, amino acids and carbohiydrates. The antimicrobial activity and minimum inhibition concentration values were determined for these phytochemical constituents as crude extracts using the agar well diffusion and two-fold serial dilution methods. The results indicated that Bacillus subtilis was the most susceptible bacterium with high inhibition zones for the methanol and chloroform extracts of 31 mm and 26 mm, respectively. The MIC values indicated that extracts possess good antimicrobial activity with significant MIC value against Enterococcus faecalis, Pseudomonas aeruginosa and Staphylococcus pneumoniae at 31.2 µg/ml concentrations. The extracts showed marked antimicrobial activity against both bacteria and fungi. Among the bacterial strains, gram-positive bacteria were more susceptible than the gram-negative. All the 13 microorganisms tested showed dose dependent susceptibility towards the phytochemicals present in the foliar extracts. The study suggests that Litsea glutinosa leaves possess potent antimicrobial activity and can be a good source for the development of new antibiotics.

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“…However, the previous investigators reported the cytotoxic property of L. glutinosa stem bark chemicals against the selected cancerous cell lines. Wang et al, 22 evaluated the cytotoxic effect of leaves and twigs of L. glutinosa against myeloid leukemia HL-60, hepatocellular carcinoma SMMC-7721, lung cancer A-549, breast cancer MCF-7 and colon cancer SW480 cells for which it was proved to be inactive (IC 50 > 40 mM). The present study also shows that the stem BEE of L. glutinosa was found to be inactive against adenocarcinoma, prostate cancer and colon carcinoma ATCC cell lines.…”

Section: Discussionmentioning

confidence: 99%

“…This is due to the biosynthesis and accumulation of phytoconstituents at different region of the plant parts and toxic specificity of the compounds against the selected cell lines. The traditional practitioners of this area orally administered the stem bark extract to cure liver diseases (Jaundice), diarrhea and dysentery [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] it was also noticed that the patients did not show any symptoms of irritability and behavior patterns such as tremors, salivation, and diarrhea. To authenticate the nontoxic effect of BEE acute toxicity experiment was conducted on albino rats.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity and Oral Acute Toxicity Studies of Litsea glutinosa C. B (ROB) Stem Bark Ethanol Extract

Sumithregowda¹,

Krishna²,

Honnenahally³

et al. 2017

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Chemotherapy is one of the potential treatments for prolonging the patient's life. Almost 60% of anticancer drugs are of natural origin, such as plants (i.e., camptothecines, irinotecan, and vincristine) and microorganisms (i.e., bleomycin, dactinomicines, doxorubicin Cytotoxicity and Oral Acute Toxicity Studies of Litsea glutinosa C. B (ROB) Stem Bark Ethanol Extract ABSTRACT Background: Litsea glutinosa (Lauraceae) stem bark is widely used in folk medicine as a hepatoprotective, anti-diarrheal and anti-dysenteric drug but there is a lack of information about its toxicity. Objective: To evaluate cytotoxicity and acute toxicity of the stem bark ethanol extract (BEE). Materials and Methods: In vitro cytotoxicity of BEE was measured against breast adenocarcinoma, prostate, and colon carcinoma cell lines. In the acute toxicity tests, rats received oral doses of BEE as 1000, 2000, and 3000 mg/kg body weight. Mortality, signs of toxicity, body weight, food consumption, and gross findings were observed for 14 days. Blood samples were collected from anesthetized animals and used for hematological and biochemical parameters. Histopathological study was performed using liver and kidney samples. Results: The BEE does not show significant cytotoxic effect against the tested cell lines up to the range from 5 to 320 µg/ml. In acute toxicity study, also lethality was not observed up to 3000 mg/kg b.w. No significant differences were noticed in body and organ weights and histopathology examinations between the control and treated groups. Conclusion: This study authenticates stem BEE may contain bioactive compounds of potential therapeutic significance which are relatively safe from toxic effects, and evidences the medicinal use of this plant in folk medicine.

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A new megastigmane diglycoside from Litsea glutinosa (Lour.) C. B. Rob.

Abstract: 40 µM).]]>

Cited by 16 publications

References 17 publications

Chemical constituents from Nectandra cuspidata Nees – Lauraceae

Chemical constituents from Nectandra cuspidata Nees – Lauraceae

Litsea glutinosa (Lauraceae): Evaluation of its Foliar Phytochemical Constituents for Antimicrobial Activity

Cytotoxicity and Oral Acute Toxicity Studies of Litsea glutinosa C. B (ROB) Stem Bark Ethanol Extract

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