Lippia sidoides essential oil encapsulation by angico gum/chitosan nanoparticles

Abstract

Nanoparticulas de quitosana (CH) e goma do angico (AG), dopadas com óleo essencial de Lippia sidoides (Ls) foram preparadas e caracterizadas em relação às suas composições, distribuição de tamanho de partículas, estabilidade térmica, bem como as liberações in vitro e in vivo. Os dados obtidos revelaram que as nanopartículas preparadas usando razões Ls:AG variando de 1:2 a 1:20, apresentaram dopagens na faixa de 3,3 a 7,7%, com eficiência de encapsulação entre 16,0 e 77,8%. Os tamanhos de partículas ficaram na faixa de 10-60 nm, com distribuições independentes do teor de óleo incorporado. FTIR revelou a presença de timol, principal componente de Ls. Análises de TGA e DSC mostraram que a incorporação de óleo na matriz resulta em nanopartículas de menor estabilidade térmica. A amostra Ls:AG = 1:10 apresentou um perfil de liberação in vitro mais lento que as demais, exibindo, porém, nos bioensaios, uma maior mortalidade larval.Chitosan (CH) and angico gum (AG) nanoparticles were loaded with essential oil, Lippia sidoides (Ls), being characterized according to their composition, size distribution, Ls:polymer ratio, thermal stability and in vitro and in vivo controlled release. Nanoparticles prepared using Ls:AG ratios of 1:2 to 1:20 had loading values of 3.3 to 7.7%, with encapsulation efficiencies in the range of 16.0 to 77.8%. Particle sizes were in the range of 10-60 nm and size distributions were independent of Ls content, for different Ls:AG ratios. Infrared spectroscopy revealed the presence of thymol in the nanoparticles. TGA and DSC revealed that the degradation temperature of AG-CH nanoparticles decreased with an increase in Ls content. Controlled-release data showed a slower release profile for samples with Ls:AG = 1:10 than for the other samples. Bioassays showed that sample Ls:AG = 1:10 has a greater larvicidal effect, with 85 ± 3% mortality.

Prolonged mosquitocidal activity of Siparuna guianensis essential oil encapsulated in chitosan nanoparticles

“…Only two articles describe chitosan-based nanoparticles with Lippia sidoides essential oil against Ae . aegypti larvae Abreu, Oliveira [26], [27], and only one study teste chitosan encapsulated oils of Geranium maculatum and Citrus bergamia against larvae of Cx . pipiens pipiens [28].…”

Nanoparticle formulation by Büchi B-90 Nano Spray Dryer for oral mucoadhesion

“…The prepared latex showed narrow particle-size distribution at 445 nm. 49 Determining the particle-size distribution of the nanospheres is important, because the target site of the nanospheres that contains the therapeutic agent is dependent on the size distribution of the powder and its bioavailability. The drug plasma concentration will oscillate if the size deviation is broad.…”

Characterization of Nanospheres Containing Zanthoxylum riedelianum Fruit Essential Oil and Their Insecticidal and Deterrent Activities against Bemisia tabaci (Hemiptera: Aleyrodidae)

“…UV-Vis spectrophotometry (DR/5000 UV-Vis HACH, Hach Company, Loveland, CO, USA) at 253.5 nm was used to quantify the essential oil of the Z. riedelianum fruits [ 34 , 79 , 80 ]. The calibration curve were obtained based on the concentrations 0.05, 0.10, 0.15, 0.20, 0.25, and 0.30 mg/mL of essential oil in hexane.…”