Cerium Chloride (CeCl3·7H2O) as a highly efficient catalyst for one-pot Three-Component Mannich reaction

Abstract

Nós demonstramos a utilização de CeCl 3•7H 2 O como catalisador altamente eficiente para reação de Mannich de três componentes para fornecer compostos β-amino carbonílicos em bons a excelentes rendimentos em curto período de reação. O processo é brando, eficiente e ambientalmente amigável com o uso de pequena quantidade de catalisador.We have demonstrated the use of CeCl 3•7H 2 O as highly efficient catalyst for one-pot threecomponent Mannich reaction to afford β-amino carbonyl compounds in good to excellent yield within shorter period of reaction time. The process is mild, efficient, environmentally benign with the use of little amount of catalyst.

An eco-friendly synthesis of 2-pyrazoline derivatives catalysed by $$\hbox {CeCl}_{3} \cdot 7\hbox {H}_{2}\hbox {O}$$ CeCl 3 · 7 H 2 O

“…Liu and Wen have proposed the participation of ethyl lactate in increasing the nucleophilicity of the amino group by hydrogen bond formation. 50 Based on mechanisms proposed by Fazaeli et al, in the synthesis of 2-pyrazolines by tungstophosphoric acid, 46 by Kidwai and Jahan in Mannich reaction catalysed by CeCl 3 · 7H 2 O, 51 and by Liu and Wen in the synthesis of keto and aldoximes in the presence of ethyl lactate, 50 we propose the following likely mechanism for this reaction (Scheme 4).…”

New Cerium (III) Complex of Schiff Base (E)-N-Benzylidene-4-Methoxyaniline: Synthesis and Density Functional Theoretical Study of Vibrational Spectra

“…The efficiency of these compounds often enhanced upon coordination to a metal has been proven for the drug action acceleration of therapeutic agents [22][23][24][25][26] and for multi-compounds reaction where these complexes are used as intermediates. Recently, extensive research has surrounded the synthesis of lanthanide complexes and precisely the cerium (III) complexes using cerium (III) heptahydrate (CeCl 3 · 7 H 2 O) 27 .…”