Synthesis and antimicrobial activity of chromone-linked 2-pyridone fused with 1,2,4-triazoles, 1,2,4-triazines and 1,2,4-triazepines ring systems

Abstract

-diamino-(6-chloro-4-oxo-4H-chromen-3-yl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile (4) with some electrophilic reagents. The structures of the novel compounds were established by elemental analyses and spectral data. All the products were also screened in vitro for their antimicrobial activity. Compounds 7, 9 and 15 showed the highest activities when compared with the reference drugs.

Antimicrobial screening of new 5-(chromene-3-yl)methylene-2,4-thiazolidinediones

“…Chromone and related compounds are wide-spread in nature and exhibit a wide range of pharmacological activity like antibacterial, antifungal (Hatzade et al, 2010, Ali andIbrahim, 2010), antitumor, anti-oxidant, anti-HIV, antiulcerant, anti-inflammatory. As a continuation of our previous work (Nastasă et al, 2013), the present study shows the antimicrobial screening of a new series of 5-(chromene-3-yl)methy-lene-2,4-thiazolidinediones (Figure 1), for which the chemical synthesis and characterization haven't yet been revealed.…”

Synthesis and Chemical Reactivity of 4‐Oxo‐4H‐1‐benzopyran‐3‐carboxaldehyde

“…6‐Chloro‐3‐formylchromone 1 reacts with a primary aromatic amine 39 containing second nucleophilic center to form triazolopyridine derivatives. Cyclocondensation of 39 with 1 in DMF containing piperidine afforded 1,2,3,5‐tetrahydrotriazolo[1,5‐ a ]pyridine derivatives 40 , which was oxidized to 2,7‐ bis (6‐chloro‐4‐oxo‐4 H ‐chromen‐3‐yl)‐5‐oxo‐1,5‐dihdro‐1,2,4‐triazolo[1,5‐ a ]pyridine‐6,8‐dicarbonitrile 41 by ferric chloride in boiling DMSO (Scheme ).…”

“…Knoevenagel condensation between 4‐oxo‐4 H ‐1‐benzopyran‐3‐carboxaldehyde 1 and malononitrile in the presence of water gave corresponding condensed product 80 , which further reacted with cyanoacetohydrazide in the presence of a catalytic amount of piperidine gave 39 (Scheme ) .…”

Synthesis and Anticancer Activity Study of Some Novel Substituted and Fused Pyridotriazepine Derivatives

“…Condensed pyrido [1,2,4]triazepines are widely reported as important bioactive molecules owing to their versatile biological activities [1][2][3]. Among the significant biological activities of these molecules are the anticancer activities against various cancer cell lines [4,5].…”