Editorial

Loh, Watson; Dias, Luiz C.

doi:10.1590/s0103-50532010000100001

Cited by 8 publications

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“…For the series 8a to 8e (Figure 8), resonance stabilization is not possible because the molecules do not have chain flexibility. Compound 8c shows potent antioxidant activity because of the presence of the SH group at R 3 position [14]. …”

Section: Reviewmentioning

confidence: 99%

Free radical scavenging properties of pyrimidine derivatives

Bano¹,

Kumar

Dudhe

2012

Organic and Medicinal Chemistry Letters

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Free radicals are well known for playing a dual role in our body- deleterious as well as beneficial. It includes a metabolic pathway for its generation. Oxidative stress in our body occurs due to excessive generation of free radicals and reduced level of antioxidants, but at low concentrations, these radicals help to perform normal physiological functions of the body. Scientific evidence suggests that antioxidants reduce the risk for chronic diseases including cancer and heart disease. This review shows current tendency in the pyrimidine synthesis and reveals the pyrimidine core to be a very potent moiety which can be a rich source for the synthesis of new compounds having desirable antioxidant activity.

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Section: Reviewmentioning

confidence: 99%

Free radical scavenging properties of pyrimidine derivatives

Bano¹,

Kumar

Dudhe

2012

Organic and Medicinal Chemistry Letters

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“…2 Be sure we will be extremely careful to follow your footsteps, experiences and example of dedication that you both gifted us. We will keep alive the dreams and the achievements of the JBCS.…”

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confidence: 99%

Honoring our heritage and moving ahead

Nóbrega¹,

Hatje²

2013

J. Braz. Chem. Soc.

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Diastereoselective Synthesis of Perfluoroalkylmethyl‐Substituted 1,2,3,4‐Tetrahydroquinolines Derivatives through 1‐Iodo‐1,3‐bis(acetoxy) Synthons

2022

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Novel 2‐perfluoroalkylmethyl,4‐arylamino substituted tetrahydroquinolines (THQ) were expeditiously synthesized from perfluoroalkyl iodides RF−I and monosubstituted anilines. First, radical bis‐addition of vinyl acetate on RF−I afforded gem‐iodoacetoxy derivatives (newly characterized by NMR and MS) being actually masked/activated aldol synthons. Their reaction in 1 : 4 ratio with arylamines afforded title THQ under mild conditions in good yields (60–95 %) and diastereoselectivities (65 : 35–95 : 5 cis/trans isomer ratio); m‐substituted anilines regiospecifically lead to 7‐substituted THQ. Mechanistic investigation suggested the THQ formation to proceed through Michael then imine addition of two aniline units on an RF‐substituted crotonaldehyde intermediate, then through the cyclization of the resulting bis(arylamino/imino) intermediate through electrophilic aromatic substitution. Various RF (C6, C2, C4) and arylamine substitutions (p‐,o‐,m‐ alkyl, alkoxyl, halogen…) were thus exemplified.

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Editorial

Cited by 8 publications

References 0 publications

Free radical scavenging properties of pyrimidine derivatives

Free radical scavenging properties of pyrimidine derivatives

Honoring our heritage and moving ahead

Diastereoselective Synthesis of Perfluoroalkylmethyl‐Substituted 1,2,3,4‐Tetrahydroquinolines Derivatives through 1‐Iodo‐1,3‐bis(acetoxy) Synthons

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