Synthesis of novel 6-(substituted benzyl)imidazo[2,1-b][1,3]thiazole catalyzed by polystyrene-supported palladium(ii) ethylenediamine complex

Synthesis of γ-butyrolactone hybrid imidazo[2,1-b][1,3]-thiazoles from limonene

“…4,5 Few reports are available on the synthesis of substituted imidazo[2,1-b] [1,3]-thiazole derivatives such as, guanylhydrazone derivatives 6 , sulfides and sulfone derivatives. 7 Bakherad et al 8 have prepared imidazothiazoles using polystyrene supported palladium complex during sonogashira coupling.…”

One-Pot Synthesis of Imidazo[2,1-b]thiazole via Groebke–Blackburn–Bienaymé Reaction under Free Catalyts

“…As far as our survey of the literature is concerned, few reports of the synthesis of As the imidazo[2,1-b]thiazole scaffolds have significant applications, a large number of routes for their synthesis have been developed. However, the classical methods imply stepwise synthesis, resulting in long time reactions, high temperatures, limited scope, low yields, and metal-catalyzed processes [5][6][7].…”

“…1 H NMR (500 MHz; CDCl 3 ; TMS): δ 8.66 (s, 1H), 8.34 (d, J = 8.0 Hz, 1H), 7.73-7.69 (m, 1H), 7.54 (d, J = 8.4 Hz, 1H), 7.47 (d, J = 4.5 Hz, 1H), 7.44 (d, J = 7.9 Hz, 1H),6.72 (d, J = 4.5 Hz, 1H), 4.90 (s, 1H), 1.05 (s, 9H); 13 C NMR (126 MHz, CDCl 3 ; TMS): δ 176.0, 156.0, 155.6, 145.6, 133.6, 130.4, 130.3, 126.4, 125.3, 124.2, 121.4, 118.3, 118.2, 111.1, 55.6, 29.7; FT-IR (ATR) Vmax /cm −1 3286 (N-H), 1629 (C=O); HRMS (ESI + ): m/z calcd. for C 18 H 18 N 3 O 2 S + 340.1114, found to be 340.1118.…”